Platelet-rich plasma and peripheral nerve regeneration: a potential contraindication to its use after tumor excision

Spartalis, Eleftherios; Athanasiou, Antonios; Spartalis, Μichael; Moris, Demetrios; Papalampros, Alexandros; Nikiteas, Nikolaos

doi:10.1080/14712598.2017.1349480

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…PRP is a plasma concentrate obtained after centrifuging whole blood, rich in growth factors, which can promote cell proliferation, regulate inflammatory responses and promote angiogenesis, thus facilitating wound repair 41,42 . PRP, due to its simple preparation, high growth factor content and low immunogenicity, is widely used in various surgical operations and clinical treatments, showing good experimental and clinical results in wound healing, especially in chronic wound healing 43,44 . Although both NPWT and PRP can promote chronic wound healing, single therapy is often insufficient.…”

Section: Discussionmentioning

confidence: 99%

“… 41 , 42 PRP, due to its simple preparation, high growth factor content and low immunogenicity, is widely used in various surgical operations and clinical treatments, showing good experimental and clinical results in wound healing, especially in chronic wound healing. 43 , 44 Although both NPWT and PRP can promote chronic wound healing, single therapy is often insufficient. Studies have suggested that combining the two can effectively improve the treatment effect of chronic wounds.…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED: Effect of platelet‐rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta‐analysis

Chen,

Xu,

et al. 2024

International Wound Journal

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A meta‐analysis was conducted to comprehensively explore the effects of platelet‐rich plasma (PRP) combined with negative pressure wound therapy (NPWT) in treating patients with chronic wounds. Computer searches were conducted, from database infection to November 2023, in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for randomized controlled trials (RCTs) on the use of PRP combined with NPWT technology for treating chronic wounds. Two researchers independently screened the literature, extracted data and conducted quality assessments according to the inclusion and exclusion criteria. Stata 17.0 software was employed for data analysis. Overall, 18 RCTs involving 1294 patients with chronic wounds were included. The analysis revealed that, compared with NPWT alone, the use of PRP combined with NPWT technology significantly improved the healing rate (odds ratios [OR] = 1.92, 95% confidence intervals [CIs]: 1.43–2.58, p < 0.001) and total effective rate (OR = 1.31, 95% CI: 1.23–1.39, p < 0.001), and also significantly shortened the healing time of the wound (standardized mean difference = −2.01, 95% CI: −2.58 to −1.45, p < 0.001). This study indicates that the treatment of chronic wounds with PRP combined with NPWT technology can significantly enhance clinical repair effectiveness and accelerate wound healing, with a high healing rate, and is worth further promotion and practice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

RETRACTED: Effect of platelet‐rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta‐analysis

Chen,

Xu,

et al. 2024

International Wound Journal

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“…14,15 Local injection of PRP is reported to be an effective modality to reduce pain, disability, and functional limitation, and to improve structural integrity and biomechanical strength for various painful conditions including tendinopathy, muscle strain injury, ligament injury, and knee osteoarthritis. [16][17][18][19][20][21] PRP was found to stimulate the metabolism of intervertebral disk cells in vitro and promote a reparative effect on rabbit degenerated intervertebral disks. 22,23 Intraarticular knee injection of PRP results in pain relief and improves knee function and quality of life in younger patients with a low degree of articular degeneration.…”

Section: Introductionmentioning

confidence: 97%

Efficacy of Platelet-rich Plasma for Low Back Pain: A Systematic Review and Meta-analysis

Zhang

Dou

et al. 2020

J Neurol Surg A Cent Eur Neurosurg

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Background Platelet-rich plasma (PRP) may be beneficial for patients with low back pain. However, the results remain controversial. We conducted a systematic review and meta-analysis to explore the efficacy of PRP for low back pain. Methods PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases were searched systematically. Randomized controlled trials (RCTs) assessing the effect of PRP on low back pain were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcome was pain scores within 8 weeks. Meta-analysis was performed using the random-effects model. Results Three RCTs involving 131 patients were included in the meta-analysis. Overall, compared with control intervention for low back pain, PRP injection was found to reduce pain scores significantly (mean difference: − 1.47; 95% confidence interval [CI], − 2.12 to − 0.81; p < 0.0001), improve the number of patients with > 50% pain relief at 3 months (risk ratio [RR]: 4.14; 95% CI, 2.22–7.74; p < 0.00001), and offer relatively good patient satisfaction (RR: 1.91; 95% CI, 1.04–3.53; p = 0.04). No increase in adverse events was reported after PRP injection (RR: 1.92; 95% CI, 0.94-3.91; p = 0.07). Conclusions Compared with control intervention for low back pain, PRP injection was found to improve pain relief and patient satisfaction significantly with no increase in adverse events.

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“…The principal debate around PRP use in cancer surgery pertains to whether it is oncologically safe to apply PRP to sites where cancer has been earlier developed and excised (44)(45)(46)(47)(48)(49)(50)(51). To date, data on the use of PRP as an adjunct to breast reconstruction after cancer treatment remain limited as opposed to adipose-derived stem cells (ASCs) or autologous fat grafting (38).…”

Section: The Oncological Safety Of Prpmentioning

confidence: 99%

The “Yin and Yang” of Platelet-rich Plasma in Breast Reconstruction After Mastectomy or Lumpectomy for Breast Cancer

Spartalis

Tsilimigras

Charalampoudis

et al. 2017

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Surgery remains the mainstay of treatment for breast cancer, including complete or partial mastectomy and lumpectomy. Breast reconstruction has gained popularity mainly due to its tremendous impact on the psychological status of the patients. Autologous fat grafting is a well-established method used in cosmetic surgery; however, fat re-absoprtion, fat necrosis, calcifications and oil-cyst formation are some usually encountered complications limiting the efficacy of this approach. Platelet-rich plasma (PRP) has recently been postulated as a promising method for tissue regeneration since it contains high levels of diverse human growth factors. To date, preliminary results from clinical studies regarding the combination of PRP and fat grafting in breast reconstruction have shown ambiguous results, whereas preclinical studies are more favorable. However, concerns have been raised regarding the extent of cellular promotion induced by PRP application and the corresponding potential malignant transformation. The aim of our study was to present, analyze and critically evaluate the role of PRP in breast reconstruction after breast cancer surgery in terms of efficacy and oncological safety highlighting the caution that needs to be taken in order to eliminate any chance of recurrence in patients who have theoretically undergone complete excision of the tumor burden.

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Platelet-rich plasma and peripheral nerve regeneration: a potential contraindication to its use after tumor excision

Cited by 4 publications

References 8 publications

RETRACTED: Effect of platelet‐rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta‐analysis

RETRACTED: Effect of platelet‐rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta‐analysis

Efficacy of Platelet-rich Plasma for Low Back Pain: A Systematic Review and Meta-analysis

The “Yin and Yang” of Platelet-rich Plasma in Breast Reconstruction After Mastectomy or Lumpectomy for Breast Cancer

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