Platelet-Rich Plasma as an Orthobiologic

Carr, Brittany Jean

doi:10.1016/j.cvsm.2022.02.005

Cited by 12 publications

(22 citation statements)

References 109 publications

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“…Multiple preparations of PRP have been developed and studied in humans, canines, felines, and equines; however, the constitutional makeup of the PRP varies greatly depending on the manufacturer, species, and method of processing, making equipment/processing specific validation important (19,20,22,34). Additionally, the constituent concentrations needed for a product to be considered PRP and have clinical efficacy are debated, with suggestions of platelet concentrations ranging from 1.5 to 5x those seen in whole blood (35)(36)(37)(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the constituent concentrations needed for a product to be considered PRP and have clinical efficacy are debated, with suggestions of platelet concentrations ranging from 1.5 to 5x those seen in whole blood (35)(36)(37)(38)(39)(40). While there is debate on whether various other constituents should be included or removed, recent studies have found that red blood cells (RBCs), neutrophils, and mononuclear cells may also affect the efficacy of a PRP product and how it contributes to the inflammatory response following PRP administration (19,41). RBCs and neutrophils are believed to be detrimental to the efficacy of intraarticular PRP as they induce unwanted inflammatory mediators that can cause synoviocyte death and impede intra-articular healing (41,42).…”

Section: Discussionmentioning

confidence: 99%

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The use of platelet rich plasma in the treatment of degenerative joint disease in cats: an exploratory case series

Huntingford,

Looney,

Johnson

et al. 2024

Front. Vet. Sci.

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ObjectiveTo evaluate the effectiveness of intra-articular autologous Platelet Rich Plasma (PRP) in managing Degenerative Joint Disease (DJD) in cats.DesignProspective pilot clinical trial.MethodsSix domestic cats with clinically and radiographically diagnosed DJD received intra-articular injections of autologous PRP. Clinical assessments pre and post intra-articular injections were conducted using the Feline Musculoskeletal Pain Index (FMPI, owner assessed) and Visual Analog Scale (VAS, clinician assessed) at baseline, Day 14, Day 28, and Day 42–45.ResultsSignificant improvements were noted in both FMPI and VAS scores at the end of the study period, indicating enhanced joint function and reduced pain.Conclusion and clinical relevanceThe study suggests the potential of PRP therapy as a safe and effective treatment for feline DJD, warranting further research with larger cohorts and longer follow-up to establish comprehensive treatment guidelines.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The use of platelet rich plasma in the treatment of degenerative joint disease in cats: an exploratory case series

Huntingford,

Looney,

Johnson

et al. 2024

Front. Vet. Sci.

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“…In our study, better histological scores were obtained in rabbits treated with IA combined with IO injections of PRGF. The use of PRP to treat musculoskeletal disorders, including OA and chondral defects, has gained interest in veterinary clinical practice during the last years and IA infiltration has shown positive clinical and functional outcomes ( 43 – 47 ). However, in patients severely affected, the IA therapy is not able to reach all the structures involved in OA pathology, especially the SB ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Intra-osseous plasma rich in growth factors enhances cartilage and subchondral bone regeneration in rabbits with acute full thickness chondral defects: Histological assessment

et al. 2023

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BackgroundIntra-articular (IA) combined with intra-osseous (IO) infiltration of plasma rich in growth factors (PRGF) have been proposed as an alternative approach to treat patients with severe osteoarthritis (OA) and subchondral bone damage. The aim of the study is to evaluate the efficacy of IO injections of PRGF to treat acute full depth chondral lesion in a rabbit model by using two histological validated scales (OARSI and ICRS II).MethodologyA total of 40 rabbits were included in the study. A full depth chondral defect was created in the medial femoral condyle and then animals were divided into 2 groups depending on the IO treatment injected on surgery day: control group (IA injection of PRGF and IO injection of saline) and treatment group (IA combined with IO injection of PRGF). Animals were euthanized 56 and 84 days after surgery and the condyles were processed for posterior histological evaluation.ResultsBetter scores were obtained in treatment group in both scoring systems at 56- and 84-days follow-up than in control group. Additionally, longer-term histological benefits have been obtained in the treatment group.ConclusionsThe results suggests that IO infiltration of PRGF enhances cartilage and subchondral bone healing more than the IA-only PRGF infiltration and provides longer-lasting beneficial effects.

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“…Activation of platelets in the PC, before their use, creates a scaffold-like membrane named platelet gel and an acellular platelet lysate (127) . There is limited consensus on variables for clinical applications, such as the total number of platelets, methods of activation, preparation, and presence or absence of white blood cells, among others, that make their use inconsistent and highly variable among research groups (128) . Therefore, standardized methods for platelet-derived products are still required.…”

Section: Cell Mediatorsmentioning

confidence: 99%

“…In veterinary medicine, treatments with platelet-derived products are typically used in musculoskeletal conditions, wound defects, and articular lesions, mainly in equine, canine, and feline patients (126) . Typically, all mentioned species, including humans, are treated with PRP or derived products for skin wounds, corneal ulcers, maxillofacial/oral surgeries, tendinopathies, articular injuries, and musculoskeletal problems (128) .…”

Section: Cell Mediatorsmentioning

confidence: 99%

Clasificación de heridas cutáneas y técnicas terapéuticas para la reparación de la piel

Galvis Escobar,

Molina Sierra,

Ruíz Soto

et al. 2023

CES Enf

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Skin wounds are a global public health concern, causing around three hundred thousand lives yearly and disabling millions more. More than 95% of these injuries occur in emerging countries where access to health services is limited, and resources are scarce. Variables such as depth, cause, infection, and/or chronicity determine the outcome of skin wounds and whether they hinder the body´s natural healing process. In order to treat deep, chronic and/or complicated skin wounds, various treatments have been developed. Widely used traditional techniques such as asepsis, debridement, and surgery are aimed to prevent further damage and aid scarring but have many disadvantages, including low efficiency results, high healing time rates, and elevated costs. Alternative and novel strategies, such as bioactive dressings and regenerative medicine, are intended to achieve functional and aesthetic tissue recovery while minimizing the rejection risk in other techniques like skin flaps and grafts. The present review outlines the key skin characteristics, a general description of the more common types of wounds and their incidence, and tissue engineered strategies commonly used for skin tissue regeneration.

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Platelet-Rich Plasma as an Orthobiologic

Cited by 12 publications

References 109 publications

The use of platelet rich plasma in the treatment of degenerative joint disease in cats: an exploratory case series

The use of platelet rich plasma in the treatment of degenerative joint disease in cats: an exploratory case series

Intra-osseous plasma rich in growth factors enhances cartilage and subchondral bone regeneration in rabbits with acute full thickness chondral defects: Histological assessment

Clasificación de heridas cutáneas y técnicas terapéuticas para la reparación de la piel

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