Platelet‐Rich Plasma–Assisted Guided Bone Regeneration for Ridge Augmentation: A Randomized, Controlled Clinical Trial

Eskan, Mehmet A.; Greenwell, Henry; Hill, Margaret; Morton, Dean; Vidal, Ricardo; Shumway, Brian S.; Girouard, Marie-Eve

doi:10.1902/jop.2013.130260

Cited by 57 publications

(89 citation statements)

References 20 publications

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“…There is a general clinical impression that the ridge augmentation results are compromised in the case of early membrane exposures [32, 33]. In this case-controlled study, which was based on a patient subset from our previous randomized clinical trial, the clinical effect of exposure of a bioresorbable matrix membrane was evaluated [27]. Based on clinical ridge width dimension measurements, a mean ridge width gain of 1.4 and 2.6 mm were calculated for the test and the control group, respectively.…”

Section: Discussionmentioning

confidence: 99%

The effect of membrane exposure on lateral ridge augmentation: a case-controlled study

Eskan¹,

Girouard²,

Morton

et al. 2017

Int J Implant Dent

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BackgroundThe effect of membrane exposure on guided bone regeneration (GBR) for lateral ridge augmentation has been poorly addressed. This case-controlled study aimed to investigate potential effect of membrane exposure lateral ridge augmentation and subsequent implant placement.MethodsA total of 14 patients that did receive lateral ridge augmentation procedure using allogeneic cancellous graft particulate in combination with an alloplastic bioresorbable matrix barrier were retrospectively selected for this study. Bone width was measured at the crest with a digital caliper before bone augmentation and at the reopening for implant placement 4 months later for all patients. Cases where primary flap closure was achieved and the barrier did not expose throughout the time until implant placement were assigned to the control group (n = 7). Cases where primary closure could not be achieved or a barrier exposure happened within the first week following the initial surgery were assigned to the test group.ResultsThe measured alveolar ridge width before surgery as well as after GBR procedure were not statistically significant different between the two groups (p > 0.05). Both groups showed a significant (p < 0.05) increase in their mean alveolar ridge width 4 months after later augmentation procedure, from 3.4 ± 1.2 to 6.0 ± 1.1 mm in the control group and from 3.6 ± 1.0 to 5.0 ± 1.4 mm in the test group. However, the mean alveolar ridge gain was significantly greater in the control group than in the test group (p < 0.05). Consequently, the reduction of the augmented alveolar ridge was significantly higher in the test group averaging to 4.7 mm than for the control group showing a loss of 3.1 mm after 4 months, respectively. However, in all 14 cases, successful implant placement was achieved after 4 months.ConclusionsWithin the limit of this study, it can be concluded that early exposure of a bioresorbable matrix barrier during lateral ridge augmentation may compromise the results of the GBR procedure but may still result in a favorable alveolar ridge width gain that allows for the placement of dental implants.

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Section: Discussionmentioning

confidence: 99%

The effect of membrane exposure on lateral ridge augmentation: a case-controlled study

Eskan¹,

Girouard²,

Morton

et al. 2017

Int J Implant Dent

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“…However, the optimal dosage and carriers for PDGF are still to be determined and further animal and human studies are necessary before clinical application. A new approach to bone augmentation is separation of platelet-rich plasma (PRP) from patient blood to be added to the graft material [362,363,364,365]. Initial results showed more and denser bone compared to autografts used alone for bone augmentation procedures [362].…”

Section: Developments and The Future Of Bone Augmentationmentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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Alveolar bone augmentation in vertical dimension remains the holy grail of periodontal tissue engineering. Successful dental implant placement for restoration of edentulous sites depends on the quality and quantity of alveolar bone available in all spatial dimensions. There are several surgical techniques used alone or in combination with natural or synthetic graft materials to achieve vertical alveolar bone augmentation. While continuously improving surgical techniques combined with the use of auto- or allografts provide the most predictable clinical outcomes, their success often depends on the status of recipient tissues. The morbidity associated with donor sites for auto-grafts makes these techniques less appealing to both patients and clinicians. New developments in material sciences offer a range of synthetic replacements for natural grafts to address the shortcoming of a second surgical site and relatively high resorption rates. This narrative review focuses on existing techniques, natural tissues and synthetic biomaterials commonly used to achieve vertical bone height gain in order to successfully restore edentulous ridges with implant-supported prostheses.

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“…In this case, we decided to mix WTA with platelet concentrates as they have shown to act as the source of growth factors promoting angiogenesis around bone graft and newly formed bone. [1819] This has been supported by findings of Gomes et al who evaluated the effects of homogenous DDM (HDDM) slices and platelet-rich plasma (PRP) in the treatment of surgical defects created in diabetic rabbits using GBR technique. Their histological analysis revealed that HDDM promoted not only increased bone formation but also superior bony microstructure owing to graft's osteoinductive and osteoconductive activities, while PRP stimulated angiogenesis and red bone marrow formation.…”

Section: Discussionmentioning

confidence: 74%

Ridge augmentation using sticky bone: A combination of human tooth allograft and autologous fibrin glue

Joshi

D'Lima

Karde

et al. 2019

J Indian Soc Periodontol

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Platelet‐Rich Plasma–Assisted Guided Bone Regeneration for Ridge Augmentation: A Randomized, Controlled Clinical Trial

Abstract: These clinical and histologic findings suggest that PRP enhanced bone regeneration and resulted in increased horizontal bone gain and percentage vital bone.

Cited by 57 publications

References 20 publications

The effect of membrane exposure on lateral ridge augmentation: a case-controlled study

The effect of membrane exposure on lateral ridge augmentation: a case-controlled study

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Ridge augmentation using sticky bone: A combination of human tooth allograft and autologous fibrin glue

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