Platelet-rich plasma-derived exosomes boost mesenchymal stem cells to promote peripheral nerve regeneration

Zhang, Yongyi; Yi, Dan; Hong, Quan; Cao, Jiangbei; Geng, Xiaodong; Liu, Jinwei; Xu, Chuang; Cao, Mengyu; Chen, Chao; Xu, Shuaixuan; Zhang, Zhen; Li, Molin; Zhu, Yaqiong; Peng, Nan

doi:10.1016/j.jconrel.2024.01.043

Cited by 10 publications

(3 citation statements)

References 63 publications

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“… [ 27 ] Platelet-Rich Plasma Increased MSC proliferation, viability, and activity, and reduced MSC apoptosis under stress. [ 28 ] Urine Regulated stone formation through the influence on focal adhesions. [ 29 ] Adipose-Derived Mesenchymal Stem Cells Improved neuronal function and neurotrophic effects.…”

Section: Overview Of the Exosomesmentioning

confidence: 99%

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Fan,

Pi,

Zou

et al. 2024

Bioactive Materials

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Section: Overview Of the Exosomesmentioning

confidence: 99%

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Fan,

Pi,

Zou

et al. 2024

Bioactive Materials

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“…In another recent study, to increase the therapeutic efficacy of MSCs, exosomes isolated from umbilical cord MSCs were cultured with exosomes derived from platelet-rich plasma containing abundant bioactive molecules (PRP-Exos), and these were found to play an active role in sciatic nerve injuries (SNI), especially in axonal regeneration and re-myelination. Researchers proved that in this case, where SNI activates the PI3K/Akt signaling pathway in the repair mechanism, PRP-Exos-MSCs promote neural repair and regeneration in PNI patients [ 123 ]. Exosomes isolated from dental pulp stem cells (DPSC-Exos) promoted axon and myelin regeneration after PNI by enhancing the migration of Schwann cells and secretion of neurotrophic factors in SNI [ 124 ].…”

Section: Stem Cell-based Evs and Nerve Regenerationmentioning

confidence: 99%

Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Yavuz,

Mutlu,

Ahmed

et al. 2024

IJMS

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Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.

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“…The findings indicate that the elevated expression of miR-21 in blood-derived exosomes following sciatic nerve ligation may partially contribute to reducing neuropathic pain [ 99 ]. Besides, Platelet-rich plasma-derived exosomes (PRP-Exo), harvested from platelet-rich plasma, exhibit tissue healing abilities and have been noted for their efficacy in addressing injuries in both the central and peripheral nervous systems [ 100 , 101 ]. In a rat model of SNI, using ultrasound to target and destroy microvesicles enhances the delivery of PRP-Exo to the injury site, significantly concentrating PRP-Exo in the damaged nerve and improving therapeutic outcomes [ 102 ].…”

Section: Exosomes For the Treatment Of Snimentioning

confidence: 99%

Exosomes repairment for sciatic nerve injury: a cell-free therapy

Xin,

Liu,

Fan

et al. 2024

Stem Cell Res Ther

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Sciatic nerve injury (SNI) is a common type of peripheral nerve injury typically resulting from trauma, such as contusion, sharp force injuries, drug injections, pelvic fractures, or hip dislocations. It leads to both sensory and motor dysfunctions, characterized by pain, numbness, loss of sensation, muscle atrophy, reduced muscle tone, and limb paralysis. These symptoms can significantly diminish a patient’s quality of life. Following SNI, Wallerian degeneration occurs, which activates various signaling pathways, inflammatory factors, and epigenetic regulators. Despite the availability of several surgical and nonsurgical treatments, their effectiveness remains suboptimal. Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nm, originating from the endoplasmic reticulum. They play a crucial role in facilitating intercellular communication and have emerged as highly promising vehicles for drug delivery. Increasing evidence supports the significant potential of exosomes in repairing SNI. This review delves into the pathological progression of SNI, techniques for generating exosomes, the molecular mechanisms behind SNI recovery with exosomes, the effectiveness of combining exosomes with other approaches for SNI repair, and the changes and future outlook for utilizing exosomes in SNI recovery.

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Platelet-rich plasma-derived exosomes boost mesenchymal stem cells to promote peripheral nerve regeneration

Cited by 10 publications

References 63 publications

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Exosomes repairment for sciatic nerve injury: a cell-free therapy

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