Platelet-rich Plasma for Skin Rejuvenation and Treatment of Actinic Elastosis in the Lower Eyelid Area

Abstract

BackgroundTreatment of the lower eyelid region to rejuvenate the skin or treat actinic elastosis often proves difficult. Established treatment options, such as hyaluronic acid injections, botulinum toxin injections, microneedling, skin resurfacing (microdermabrasion, chemical peel (exfoliation), laser treatment), as well as blepharoplasties and autologous fat transfers, can be associated with significant risks and increased patient burden. Furthermore, they may not be effective for treating the signs of skin aging or actinic elastosis, including dark rings under the eyes, a lack of volume and cutis laxa. A minimally invasive treatment approach which visibly improves the above-mentioned conditions and which involves minimal risk and patient burden would be a desirable alternative.Materials & methodsTwenty patients were treated a total of three times at monthly intervals with PRP (platelet-rich plasma). The patients were examined on the days of treatment and one month after the third injection. The PRP was obtained directly prior to treatment using the Arthrex ACP double syringe at the point of care. The injections (2 ml PRP per side) were administered laterally using 27 G 38 mm cannulas. Accurate photographic documentation and skin elasticity measurements using a cutometer were performed to objectify the subjective assessments from the patient and practitioner questionnaires.ResultsA progressive improvement in the esthetic outcome and a high level of patient satisfaction were determined. The cutometer measurements showed a statistically significant higher level of skin firmness (due to increased collagen production) and a statistically significant increase in skin elasticity (thanks to increased elastin production). Other than the anticipated visible swelling directly after the PRP injection, no other undesirable side effects or complications occurred. The typical burning sensation during the injection had not been reported.ConclusionThe results indicate that a series of PRP injections in the lower eyelid region is a safe, efficient, virtually pain-free, simple and rapid treatment option for an area with otherwise limited treatment alternatives.

Update in minimally invasive periorbital rejuvenation with a focus on platelet‐rich plasma: A narrative review

“…The effect of PRP injections in lower eyelid rejuvenation and treatment of actinic elastosis showed a statistically significant higher level of skin elasticity and skin firmness after three monthly injections of PRP 56 …”

O uso do plasma rico em Plaquetas no Rejuvenescimento Facial: Uma Revisão Integrativa / Use of rich Plasma on platelets in Facial Rejuvenation: An Integrating Review

“…Em áreas expostas, os processos intrínseco e extrínseco se sobrepõem. As principais causas extrínsecas de envelhecimento cutâneo incluem: o tabagismo, a má nutrição e a exposição solar, responsável por 80% a 90% do envelhecimento facial (PAVANI;FERNANDES, 2017;AUST et al, 2018).…”

“…Também reduzem a síntese do colágeno, reduzindo os receptores do fator de crescimento β do tipo II (TGF-β2) inibindo a expressão do gene dos protocolágenos tipo I e III, que levam à formação alterada de colágeno. Embora este dano cutâneo relacionado não seja inicialmente visível, ao longo do tempo, com a exposição nociva continuada aos raios UV, as rugas e a elastose actínica acabarão por resultar (AUST et al, 2018;AMINI et al, 2015 (COSTA;SANTOS, 2016). Duymus e colaboradores avaliaram três métodos de obtenção do PRP, sendo a dupla centrifugação mais efetiva (ESAT et al, 2016).…”

“…Os fatores de crescimento são liberados após a ativação endógena ou exógena das plaquetas e, em seguida, agem direta e indiretamente para regenerar o tecido (AUST et al, 2018;ZHANG et al, 2018). Algumas poucas plaquetas são ativadas por influências mecânicas durante a centrifugação.…”

Arbeitsgemeinschaften und assoziierte Gesellschaften (AKS)

“…Des Weiteren werden durch chemotaktische Faktoren unter anderem Fibroblasten und mesemchymale Stammzellen angelockt. Die Produktion von Kollagen und Elastin wird stimuliert und die Textur und Lumineszenz der Haut sichtbar verbessert .…”