Platelet-Rich Plasma for Vocal Fold Scar: A Preliminary Report of Concept

Bhatt, Neel K.; Gao, William; Sund, Lauren Timmons; Castro, M. Eugenia; O’Dell, Karla; Johns, Michael M.

doi:10.1016/j.jvoice.2020.12.040

Cited by 13 publications

(16 citation statements)

References 23 publications

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“…As of today, PRP is not widely used in head and neck surgery. A brief literature search revealed mostly studies on its use in phoniatric procedures7–9 and nasosinusal healing after endoscopic sinus surgery 11 12. Furthermore, many of these works were animal-based studies,8 10 11 reflecting the need of more studies to be carried out in humans.…”

Section: Discussionmentioning

confidence: 99%

“…PRP is extremely inexpensive, as the only equipment needed is a centrifuge, which is present in most hospital settings. As PRP has an autologous origin, being obtained from the patient’s blood, no significant adverse effects have been reported5; even though they are not numerous, studies in which PRP was used in head and neck surgery show that it is completely safe 7 9 12 15 16…”

Section: Discussionmentioning

confidence: 99%

“…Its application is widely diffused, especially in orthopaedics, periodontics, maxillofacial surgery and plastic surgery,6 as its healing effects are especially significant for tendons, ligament and cartilage 5. In head and neck surgery, its use, as of today, is not widely diffused, and is mostly limited to phoniatric procedures7–10 and naso-sinusal healing after endoscopic sinus surgery 11 12…”

Section: Introductionmentioning

confidence: 99%

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Use of platelet-rich plasma in irradiated patients to treat and prevent complications of head and neck surgery

et al. 2022

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Nowadays, many patients facing head and neck oncological surgery have a history of tissue irradiation. This represents an important risk factor for postsurgical complications, including dehiscences and fistulas. Platelet-rich plasma (PRP) obtained from the patient’s blood represents an easy, fast and inexpensive method for the prevention and treatment of such complications. We present three cases of previously irradiated patients in which PRP was successfully used to prevent and treat postsurgical complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Use of platelet-rich plasma in irradiated patients to treat and prevent complications of head and neck surgery

et al. 2022

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“…In vitro and in vivo experiments showed a significant decrease in collagen deposition and increase in hyaluronic acid production in both the acute and chronic phases of vocal fold injury following administration of exogenous growth factors, namely, epidermal growth factor, bFGF, transforming growth factor beta 1, and hepatocyte growth factor 3 . Furthermore, progress has been made in the therapeutic administration of platelet‐rich plasma 31 and bone marrow‐derived autologous stem cells 32 . bFGF injection has become a leading treatment for vocal fold atrophy and paralysis 18,19,21 .…”

Section: Discussionmentioning

confidence: 99%

Intracordal injection therapy for vocal fold scarring: Steroid versus basic fibroblast growth factor

Nozawa

Takahashi

Kanazawa

et al. 2022

Laryngoscope Investig Oto

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Objectives Vocal fold scarring is caused by replacement of vocal fold mucosa with fibrous tissue due to repeated inflammation or trauma. It can lead to severe dysphonia. It is currently treated conservatively and with phonosurgery and intracordal injections. Intracordal injection of steroid or basic fibroblast growth factor (bFGF) has been recently found to be useful for treating vocal fold scarring that does not respond to voice therapy. Methods This retrospective study involved the administration of steroid injection and bFGF injection bilaterally under local anesthesia in 16 patients each. Laboratory measurements of voice parameters were performed before and 3–6 months after injection. Results In the steroid injection group, the Voice Handicap Index (VHI) score significantly improved from 57.1 to 40.5, total Grade, Roughness, Breathiness, Asthenia, Strain (tGRBAS) score significantly improved from 4.2 to 2.6, and mean speech fundamental frequency (SFF) increased from 192.5 to 211.4 dB, but there was no improvement in maximum phonation time (MPT) and mean airflow rate (MFR). In the bFGF injection group, significant improvements in the VHI score (from 53.3 to 35.7), MPT (from 16.9 to 21.8 s) and MFR (from 314.6 to 210.5 ml/s) were seen; however, the tGRBAS score did not improve. In addition, the SFF significantly decreased from 178.1 to 160.5 Hz. Conclusion These results suggest that both steroid and bFGF injections are effective for treating vocal fold scarring, with steroids improving voice quality and bFGF improving glottic closure, thereby contributing to improvements in VHI scores. Level of Evidence 4.

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“…As presbylaryngis is a form of glottic insu ciency, it can be treated with methods to increase glottic contact, such as voice therapy, injection laryngoplasty, and medialization thyroplasty [7][8][9]. In addition to medialization by injection of space-occupying materials (e.g., calcium hydroxyapatite), the use of various substances, such as growth factors, platelet-rich plasma, and stem cells, has been examined to restore the sophisticated and unique structure of vocal-fold mucosa and muscles both in vivo and in clinical trials [10][11][12]. Regeneration of laryngeal tissues and restoration of intrinsic laryngeal functions are challenging problems that have yet to be addressed by existing injectable materials.…”

Section: Introductionmentioning

confidence: 99%

Injection Laryngoplasty of Human Adipose-derived Stem Cell Spheroids With Hyaluronic Acid-based Hydrogel Improves the Morphological and Functional Characteristics of Geriatric Larynx

Lee

Choi

et al. 2022

Preprint

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Aim: As the geriatric population increased, the need of treatment for laryngeal atrophy and dysfunction increased. This study was performed to evaluate the effects of injection of human adipose-derived stem cell (hASC) spheroid-loaded catechol-conjugated hyaluronic acid (HA-CA) hydrogel on therapeutic rejuvenation of the geriatric larynx. Methods: Stem cell spheroids with hyaluronic acid-based hydrogel were injected into the laryngeal muscles of 18-month-old Sprague–Dawley rats. The effects of hASC spheroids were examined in the following four groups: SHAM, injected with PBS; GEL, injected with HA-CA hydrogel; MONO, injected with single hASCs in HA-CA hydrogel; and SP, injected with hASCs spheroids in HA-CA hydrogel. The rejuvenation efficacy in geriatric laryngeal muscle tissues at 12 weeks postinjection was evaluated and compared by histology, immunofluorescence staining, and functionality analysis. Results: Total myofiber cross-sectional area and myofiber number/density, evaluated by detection of myosin heavy chain with antibodies against laminin and fast myosin heavy chain, were significantly higher in the SP group than in the other groups. The lamina propria of the larynx was evaluated by alcian blue staining, which showed that the HA was increased significantly in the SP group compared to the other groups. In functional analysis, the glottal gap area was significantly reduced in the SP group compared to the other groups. The phase difference in the vocal fold during vibration was also smaller in the SP group than in the other groups, but the difference did not reach statistical significance.Conclusion: Injection of hASC spheroids with hyaluronic acid-based hydrogel improves the morphological and functional characteristics of geriatric larynx

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Platelet-Rich Plasma for Vocal Fold Scar: A Preliminary Report of Concept

Cited by 13 publications

References 23 publications

Use of platelet-rich plasma in irradiated patients to treat and prevent complications of head and neck surgery

Use of platelet-rich plasma in irradiated patients to treat and prevent complications of head and neck surgery

Intracordal injection therapy for vocal fold scarring: Steroid versus basic fibroblast growth factor

Injection Laryngoplasty of Human Adipose-derived Stem Cell Spheroids With Hyaluronic Acid-based Hydrogel Improves the Morphological and Functional Characteristics of Geriatric Larynx

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