Platelet‐rich plasma in animal reproductive medicine: Prospective and applications

Abstract

Platelet‐rich plasma (PRP) is the fraction of the plasma enriched with a platelet level above baseline, and it plays an essential role in tissue regeneration. The attention to PRP as unconventional therapy has increased during the past two decades. In animals, applications of PRP showed various degrees of success in a wide range of medical applications, from musculoskeletal injuries to ovarian insufficiency. Therapeutic applications with PRP in farm animals are still scarce, but the promising results offered by several studies are expected to trigger more interest in its application by both veterinarians and farmers. In this review, we highlight some efforts made in the field of animal reproduction regarding the use of PRP to potentiate the ovarian hypofunction, treat endometritis, improve the follicular development, oocyte competence and uterine environment for embryo implantation as well as restore testicular and erectile function in male, and as a treatment for mastitis.

Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility

“…Activated PRP releases cytokines and growth factors, like transforming growth factor-beta, fibroblast growth factor, insulin-like growth factors 1 and 2, VEGF and epidermal growth factor [49]. Besides human applications, PRP is used in animal reproductive medicine to treat endometritis and improve follicular development, oocyte competence and the uterine environment for embryo implantation [50][51][52].…”

Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway

“…PRP includes abundant of growth factors such as platelet derived growth factor (PDGF), transforming growth factor-β (TGF-β), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and basic fibroblast growth factor (BFGF), which are contributed in the process of healing, angiogenesis, and inflammation. 13 Easy availability after simple centrifugation, low immunogenicity, properties of modifying the injured site manifested noticeable superiorities of PRP. 14 Due to the good healing properties of PRP, it is clinically applied in the treatment of knee osteoarthritis, 15 androgenetic alopecia, 16 and nerve lesion recovery.…”

“…Platelet‐rich plasma (PRP) is plasma enriched with platelets that extracted from fresh whole blood. PRP includes abundant of growth factors such as platelet derived growth factor (PDGF), transforming growth factor‐β (TGF‐β), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), insulin‐like growth factor‐1 (IGF‐1), and basic fibroblast growth factor (BFGF), which are contributed in the process of healing, angiogenesis, and inflammation 13 . Easy availability after simple centrifugation, low immunogenicity, properties of modifying the injured site manifested noticeable superiorities of PRP 14 .…”