Platelet Rich Plasma in Orthopedic Surgical Medicine.

Everts, Peter A.; Erp, Albert van; Desimone, A; Cohen, Dan S.; Gardner, Ronald D.

doi:10.1080/09537104.2020.1869717

Cited by 72 publications

(43 citation statements)

References 91 publications

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“…Additionally, it is important to consider that many growth factors in PRP have a limited biological half-life, which can explain, at least in part, the variability seen with PRP treatment outcomes. Once the growth factor levels are too high compared to the available receptors, they might negatively affect cell function [ 22 , 42 ]. The problem with PRP standardization could be solved using characterized lyophilized PRP powder.…”

Section: In Vitro Studiesmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

Szwedowski

Szczepanek

Paczesny³

et al. 2021

IJMS

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Knee osteoarthritis (KOA) represents a clinical challenge due to poor potential for spontaneous healing of cartilage lesions. Several treatment options are available for KOA, including oral nonsteroidal anti-inflammatory drugs, physical therapy, braces, activity modification, and finally operative treatment. Intra-articular (IA) injections are usually used when the non-operative treatment is not effective, and when the surgery is not yet indicated. More and more studies suggesting that IA injections are as or even more efficient and safe than NSAIDs. Recently, research to improve intra-articular homeostasis has focused on biologic adjuncts, such as platelet-rich plasma (PRP). The catabolic and inflammatory intra-articular processes that exists in knee osteoarthritis (KOA) may be influenced by the administration of PRP and its derivatives. PRP can induce a regenerative response and lead to the improvement of metabolic functions of damaged structures. However, the positive effect on chondrogenesis and proliferation of mesenchymal stem cells (MSC) is still highly controversial. Recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, significant progress has been made in understanding the mechanism of PRP action. In this review, we will discuss mechanisms related to inflammation and chondrogenesis in cartilage repair and regenerative processes after PRP administration in in vitro and animal studies. Furthermore, we review clinical trials of PRP efficiency in changing the OA biomarkers in knee joint.

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Section: In Vitro Studiesmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

Szwedowski

Szczepanek

Paczesny³

et al. 2021

IJMS

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“…(3), c P2,EPP,opt = c P2,Blood /(1-x max /L Blood +(x max x min,Blood ) 1/2 /L Blood ) . (6) Average calculated c P2,EPP,opt for our cohort was 463.10 9 /L, which is about 15% more than obtained in experiment (399.10 9 /L, Table I).…”

Section: Enrichment Of Epp In P2 Particles and Recovery Of P2 Particles After Spin Bloodmentioning

confidence: 40%

“…Blood plasma enriched in platelets has been demonstrated to possess regenerative and angiogenic properties [1][2][3] and has become a subject of increasing interest in different fields of medicine [4][5][6]. Its impact on hemostasis and immune and inflammatory responses [2,3] has initially been ascribed to platelets.…”

Section: Introductionmentioning

confidence: 99%

Enrichment of plasma in platelets and extracellular vesicles by the counterflow to erythrocyte settling

et al. 2021

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In order to prepare optimal platelet and extracellular vesicle (EV)-rich plasma for the treatment of chronic temporal bone inflammation, we studied effects of centrifugation parameters on redistribution of blood constituents in blood samples of 23 patients and 20 volunteers with no record of disease. Concentrations of blood cells and EVs were measured by flow cytometry. Sample content was inspected by scanning electron microscopy. A mathematical model was constructed to interpret the experimental results. The observed enrichment of plasma in platelets and EVs after a single spin of blood depended on the erythrocyte sedimentation rate, thereby indicating the presence of a flow of plasma that carried platelets and EVs in the direction opposite to settling of erythrocytes. Prolonged handling time correlated with the decrease of concentration of platelets and larger EVs in platelet and EV-rich plasma (PVRP), R = −0.538, p = 0.003, indicating cell fragmentation during the processing of samples. In further centrifugation of the obtained plasma, platelet and EV enrichment depended on the average distance of the sample from the centrifuge rotor axis. Based on the agreement of the model predictions with observations, we propose the centrifugation protocol optimal for platelet and EV enrichment and recovery in an individual sample, adjusted to the dimensions of the centrifuge rotor, volume of blood and erythrocyte sedimentation rate.

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“…Because each PRP preparation method leads to different products with different biological functions, the regulation of PRP applications, both in clinical research and basic science, is confusing. Although the FDA has approved several commercial preparation systems for PRP preparation, uniform quality assessment and standardized preparation procedures have not been agreed upon worldwide ( Zhang Y. J. et al, 2018b ; Everts et al, 2021 ).…”

Section: Tissue Regeneration Strategies For Achilles Tendon Injury Tr...mentioning

confidence: 99%

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Zhu

He²,

Ji³

et al. 2022

Front. Bioeng. Biotechnol.

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The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.

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Platelet Rich Plasma in Orthopedic Surgical Medicine.

Cited by 72 publications

References 91 publications

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis

Enrichment of plasma in platelets and extracellular vesicles by the counterflow to erythrocyte settling

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

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