Platelet-Rich Plasma in Pain Medicine

Lana, José Fábio Santos Duarte; Vicente, Eduardo F.; Weglein, Adam; Belangero, William Dias; Assis, Fabrício Dias; Mansano, André Marques

doi:10.1007/978-1-4471-7271-0_2

Cited by 4 publications

(6 citation statements)

References 82 publications

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“…Patients were instructed to avoid lifting weights on the affected limb for 2 weeks [ 14 ] and refrain from any NSAIDs for 1 month.…”

Section: Baseline Assessmentmentioning

confidence: 99%

“…Exclusion criteria included patients with a history of shoulder surgery, fracture, dislocation or subluxation, full-thickness rotator cuff tear, positive “drop arm sign”, frozen shoulder or degenerative arthropathy of the glenohumeral joint, cervical spine or upper extremity disorders with a significant impact on the shoulder, diabetes mellitus, active infection or other painful, function-limiting disorders of the shoulder and significant systemic disease [ 2 , 4 , 14 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of lyophilized growth factors injection for subacromial impingement syndrome: a prospective randomized double-blind placebo-controlled study

et al. 2023

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Background Platelet-derived lyophilized growth factors (L-GFs) use a standardized number of allogenic pathogen-free platelets instead of autologous platelets used in PRP as a source of growth factors. This study aimed to evaluate the efficacy of L-GF injection versus placebo in subacromial impingement (SIS) treatment. Methods The current randomized double-blind placebo-controlled study included sixty patients (40 females and 20 males, aged between 24 and 75 years) diagnosed with SIS (both clinically and sonographically). Patients were randomly assigned to two equal groups. Under ultrasound guidance, group 1 received subacromial saline injection, and group 2 received L-GF injection. Clinical examination, pain visual analogue scale (VAS), shoulder pain and disability index (SPADI) and shoulder ultrasound were performed before and at the 8th week after injection. Results Follow-up assessment showed statistically significant improvement in the L-GF group regarding active flexion, active and passive internal rotation and extension, SPADI-disability scale, VAS and thickness of the supraspinatus tendon by US. Regression analysis showed that group 1 was approximately 30 times more likely than the L-GF group to experience painful arc at follow-up. Both groups showed statistically significant improvement in SPADI-pain scale and SPADI-total, flexion and abduction (still the mean value of abduction was significantly higher in the L-GF group). Conclusions L-GF injection resulted in clinically significant reductions in pain and functional disability outcomes in patients with SIS. An objective significant reduction in the thickness of the supraspinatus tendon, measured by ultrasound, in the L-GF group hopefully encourages proper healing and functioning in SIS. Trial registration: The identification number is NCT04330027, date of first registration (01/04/2020). Unique on 21/11/2019, Protocol ID: 0106178.

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“…Patients were instructed to avoid lifting weights on the affected limb for 2 weeks [ 14 ] and refrain from any NSAIDs for 1 month.…”

Section: Baseline Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effectiveness of lyophilized growth factors injection for subacromial impingement syndrome: a prospective randomized double-blind placebo-controlled study

et al. 2023

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“…Of the RCTs included for analysis, n=21 (77.8%) were Level I RCTs, with two of these studies (9.5%) being prospective multi-center trials. 23,41 Significant variability existed with respect to numerous aspects of the inclusion and exclusion criteria utilized (See Appendix). With respect to arthritis grade, the majority of studies utilized Kellgren-Lawrence grading systems (n=25, 85.2%) as opposed to the Ahlback osteoarthritis grade (n=4) (Figure 2).…”

Section: Variability In Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…MRI, XRay). 22,41 Ethical concerns and the importance of clinically improvement rather than radiographic progression were also mentioned. 35 RCT: randomized controlled trial Title/Abstracts were screened based on having both "knee arthritis" or "knee osteoarthritis" and "PRP" or "plasma rich protein"…”

Section: Limitationsmentioning

confidence: 99%

A systematic review on the high variability in study design and outcome reporting in randomized controlled trials examining intra-articular platelet-rich plasma injection for knee osteoarthritis

Beletsky

Vadhera

Strauss³

et al. 2022

Journal of Cartilage & Joint Preservation

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Since there is a high concentration of platelet growth factors in small volumes of plasma that works to provide a "perfect environment" for tissue regeneration and is considered biological therapy, platelet-rich plasma (PRP) is a revolutionary therapeutic technique that was developed in the 1950s and is now used in many fields of medicine [9].…”

mentioning

confidence: 99%

Role of platelet rich plasma in improving quality of life in patients with atrophic rhinitis

Mostafa

Seddik

Farag

2023

Fayoum University Medical Journal

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Platelet-Rich Plasma in Pain Medicine

Cited by 4 publications

References 82 publications

Effectiveness of lyophilized growth factors injection for subacromial impingement syndrome: a prospective randomized double-blind placebo-controlled study

Effectiveness of lyophilized growth factors injection for subacromial impingement syndrome: a prospective randomized double-blind placebo-controlled study

A systematic review on the high variability in study design and outcome reporting in randomized controlled trials examining intra-articular platelet-rich plasma injection for knee osteoarthritis

Role of platelet rich plasma in improving quality of life in patients with atrophic rhinitis

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