Platelet‐rich plasma influence on the sternal wounds healing: A meta‐analysis

Abstract

A meta‐analysis research was executed to appraise the effect of platelet‐rich plasma (PRP) on sternal wound healing (SWH). Inclusive literature research till April 2023 was done and 1098 interconnected researches were revised. The 11 picked researches, enclosed 8961 cardiac surgery (CS) persons were in the utilised researchers' starting point, 3663 of them were utilising PRP, and 5298 were control. Odds ratio (OR) and 95% confidence intervals (CIs) were utilised to appraise the effect of PRP on the SWH by the dichotomous approach and a fixed or random model. PRP had significantly lower sternal wound infection (SWI) (OR, 0.11; 95% CI, 0.03–0.34, p < 0.001), deep SWI (OR, 0.29; 95% CI, 0.16–0.51, p < 0.001), and superficial SWI (OR, 0.20; 95% CI, 0.13–0.33, p < 0.001), compared to control in CS persons. PRP had significantly lower SWI, deep SWI, and superficial SWI, compared to control in CS persons. However, caution must be taken when interacting with its values since there was a low sample size of some of the nominated research found for the comparisons in the meta‐analysis.

Use of Platelet-Rich Plasma in the prevention of cardiovascular surgical wound infections: Integrative review

“…The third meta-analysis used as a comparison was Zhu et al (2023), this paper demonstrated that the use of PRP reduces the chances of DSWI and SWI after thoracic surgeries, however, the authors highlight the possibility of bias as the sample used was small and, in addition, the meta-analysis may present selection bias since other researches were not included.…”