Platelet rich plasma injections for lateral epicondylitis of the elbow reduce the need for surgical intervention

Hastie, Graham R; Soufi, M; Wilson, James D.; Roy, Biswajit

doi:10.1016/j.jor.2018.01.046

Cited by 28 publications

(21 citation statements)

References 23 publications

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“…Interest in PRP and its clinical applications has been steadily increasing as more researchers are seeing consistent positive results in multiple fields. With such great success in the treatment of lateral epicondylitis, 16,63 the first goal of clinical research was to determine if PRP injections were superior to other current injection options in the management of OA (►Table 1).…”

Section: Clinical Sciencementioning

confidence: 99%

“…Clinical use of PRP injections has gained traction in plastic surgery, 12 maxillofacial surgery, 13 wound healing, 14 and dermatology. 15 In the practice of sports medicine, PRP injections have been used in the treatment of lateral epicondylitis, showing reduced rates of conversion to surgical treatment from medical management, 16 as well as marked improvement in visual analog scale (VAS) pain scale and tendon appearance on magnetic resonance imaging (MRI). 17 Furthermore, PRP has been shown to provide relief from pain and inflammation associated with OA, making it a therapeutic treatment in the management of OA.…”

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confidence: 99%

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The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis

et al. 2018

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With average life expectancy and the rising prevalence of obesity, osteoarthritis (OA) is creating an increasingly large financial and physical burden on the U.S. population today. As the body ages and experiences trauma, articular cartilage surfaces in joints are gradually worn away, leading to OA. Traditionally, treatment options have included lifestyle modifications, pain management, and corticosteroid injections, with joint replacement reserved for those who have exhausted nonsurgical measures. More recently, hyaluronic acid, micronized dehydrated human amniotic/chorionic membrane tissue, and platelet-rich plasma (PRP) injections have started to gain traction. PRP has been shown to have both anti-inflammatory effects through growth factors such as transforming growth factor-β and insulin-like growth factor 1, and stimulatory effects on mesenchymal stem cells and fibroblasts. Multiple studies have indicated that PRP is superior to hyaluronic acid and corticosteroids in terms of improving patient-reported pain and functionality scores. Unfortunately, there are many variations in PRP preparation, and lack of standardization in factors, such as speed and duration of centrifugation, leads to wide ranges of platelet and leukocyte concentrations. This review examines the current literature addressing the use of PRP in symptomatic knee OA and addresses suggestions for future studies in this area.

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Section: Clinical Sciencementioning

confidence: 99%

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confidence: 99%

The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis

et al. 2018

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“…Despite the heterogeneity of data, a seven-year retrospective study [250] and several meta-analyses, differing for inclusion criteria are available for evaluation the effectiveness of PRP in the treatment of lateral epicondylitis [251][252][253][254][255].…”

Section: Lateral Epicondyle Tendinopathymentioning

confidence: 99%

Platelet Concentrates in Musculoskeletal Medicine

Mariani

Pulsatelli

2020

IJMS

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Platelet concentrates (PCs), mostly represented by platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biological blood-derived products that may combine plasma/platelet-derived bioactive components, together with fibrin-forming protein able to create a natural three-dimensional scaffold. These types of products are safely used in clinical applications due to the autologous-derived source and the minimally invasive application procedure. In this narrative review, we focus on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculoskeletal medicine, efficacy and main limits of the different studies.

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“…Furthermore, autologous blood products have gained popularity in the treatment of tissue healing in orthopedic settings. Platelet-rich plasma and autologous whole blood are proven to have tendon regenerative effects by supplementing with various growth factors such as platelet derived growth factor, transforming growth factor, platelet factor 4, interleukin-1, and vascular endothelial growth factor, and by increasing vascularity to eventually increase tendon thickness and improve the anatomical tendinous morphology [ 25 ]. Since corticosteroids, considered the mainstay of an intervention therapy with injection, have limited long-term effects and results in tendon degeneration with chronic use, biologic enhancement injectates like platelet-rich plasma or autologous blood are expected to exert their efficacies and long term effects in pain resolution as well as tendon regeneration [ 26 ].…”

Section: Current Updates On Interventional Therapy With Injectionmentioning

confidence: 99%

Current Trends for Treating Lateral Epicondylitis

Kim

Yoo

Choi

et al. 2019

Clin Shoulder Elbow

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Lateral epicondylitis, also known as ‘tennis elbow’, is a degenerative rather than inflammatory tendinopathy, causing chronic recalcitrant pain in elbow joints. Although most patients with lateral epicondylitis resolve spontaneously or with standard conservative management, few refractory lateral epicondylitis are candidates for alternative non-operative and operative modalities. Other than standard conservative treatments including rest, analgesics, non-steroidal anti-inflammatory medications, orthosis and physical therapies, nonoperative treatments encompass interventional therapies include different types of injections, such as corticosteroid, lidocaine, autologous blood, platelet-rich plasma, and botulinum toxin, which are available for both short-term and long-term outcomes in pain resolution and functional improvement. In addition, newly emerging biologic enhancement products such as bone marrow aspirate concentrate and autologous tenocyte injectates are also under clinical use and investigations. Despite all non-operative therapeutic trials, persistent debilitating pain in patients with lateral epicondylitis for more than 6 months are candidates for surgical treatment, which include open, percutaneous, and arthroscopic approaches. This review addresses the current updates on emerging non-operative injection therapies as well as arthroscopic intervention in lateral epicondylitis.

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Platelet rich plasma injections for lateral epicondylitis of the elbow reduce the need for surgical intervention

Abstract: We consider PRP injection, for intractable lateral epicondylitis of the elbow, not only a safe but also very effective tool in reducing symptoms and have shown it has reduced the need for surgical intervention in this difficult cohort of patients.

Cited by 28 publications

References 23 publications

The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis

The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis

Platelet Concentrates in Musculoskeletal Medicine

Current Trends for Treating Lateral Epicondylitis

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