Platelet-rich plasma promotes epithelialization and angiogenesis in a splitthickness skin graft donor site

Kakudo, Natsuko; Kushida, Satoshi; Minakata, Tatsuya; Suzuki, Kenji; Kusumoto, Kenji

doi:10.1007/s00795-010-0532-1

Cited by 56 publications

(48 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This series witnessed improvement in the wound healing in the PRP side as evident by the significant increase in the epithelialization surface area in the PRP side at days 7 and 14 postoperative (p < 0.001 and p = 0.039 respectively). Similar to our study and findings, Kakudo et al [16] studied the effect of PRP on the donor site of STSG and noticed macroscopic epithelialization on the 5 th day of PRP application. In another study, Spyridakis et al [17] noted that complete wound closure was statistically faster in the PRP treated wounds.…”

Section: Discussionsupporting

confidence: 92%

Clinical Safety and Efficacy of Platelet-Rich Plasma in Wound Healing

Ghoraba¹,

Mahmoud²,

Hammad³

et al. 2016

IJCM

View full text Add to dashboard Cite

Background: Platelet-rich plasma has been extensively used in several clinical settings. However, there still a lack of conclusive evidence concerning the benefits of platelet-rich plasma in the field of wound healing. We aimed to evaluate the safety and the efficacy of autologous platelet-rich plasma in acute wound healing. Methods: This prospective study enrolled forty adult patients of both sexes and aged between 18 -50 years. All patients in need for split-thickness skin graft were included in our study. The donor sites were randomly divided into two equal halves: the platelet-rich plasma side, which was injected with recently activated platelet-rich plasma; and the control side, in which the conventional method of dressing was used. Measurement of the platelet count and transforming growth factor-B1 concentration in each platelet-rich plasma preparation and the whole blood was done for all patients. Clinical monitoring of the donor sites was done every 7 days for 3 weeks, regarding pain perception, epithelialization surface area and possible side effects of the platelet-rich plasma. Histopathological monitoring was done on the 7 th postoperative day. Results:The platelet count was increased about 3.5 folds and transforming growth factor-B1 was increased 2.4 folds in the platelet-rich plasma compared to the patients' blood. The platelet-rich plasma side had significantly lower pain scores at day 7 (4.8 ± 0.18 vs 5.9 ± 0.07) and day 14 (1.4 ± 0.11 vs 1.9 ± 0.09) postoperative (p = 0.002 and p = 0.004, respectively) and had significantly higher rate of epithelialization at day 7 (9.8 ± 0.35 cm 2 vs 7.5 ± 0.32 cm 2 ) and day 14 (38.4 ± 0.36 cm 2 vs 36.9 ± 0.42 cm 2 ) postoperative (p < 0.001 and p = 0.039, respectively), while at day 21 postoperative, there was no significant difference between both sides. There was no significant difference between both sides regarding the incidence of complications. The platelet-rich plasma side showed intact epithelium, differentiation of the cells in stratum spongiosum and stratum granulosum, neovascularization and earlier collagen deposition. Conclusion:The platelet-rich plasma is safe and effective adjuvant in the management of acute wounds. However, we recommend for larger clinical trials for standardized method for PRP preparation and better understanding of the efficacy of this blood product.

show abstract

Section: Discussionsupporting

confidence: 92%

Clinical Safety and Efficacy of Platelet-Rich Plasma in Wound Healing

Ghoraba¹,

Mahmoud²,

Hammad³

et al. 2016

IJCM

View full text Add to dashboard Cite

show abstract

“…These characteristics of platelets have led to the idea of using platelets as therapeutic tools to promote wound healing, particularly in patients whose tissue repair is significantly impaired or delayed [1]. We previously reported that PRP promoted fibroblast growth [2] and induced epithelialization and neovascularization at split thickness skin graft donor sites [6]. Other investigators have used platelet growth factors to treat nonhealing wounds [7].…”

Section: Discussionmentioning

confidence: 99%

The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series

Kakudo¹,

Kushida²,

Ogura³

et al. 2012

OJRM

Self Cite

View full text Add to dashboard Cite

Platelet-rich plasma (PRP) contains a high concentration of thrombocytes and the -granules of platelets contain platelet-released growth factors. The usefulness of PRP for regeneration of bone and soft tissues has been reported previously. We firstly reported the efficacy of PRP prepared using the Magellan ® Autologous Platelet Separator System for intractable skin ulcers such as diabetic and venous ulcers. The system consists of a microprocessor-controlled centrifuge, syringe pumps, and necessary single-use processing components. No complications occurred in any patients and the wounds achieved complete epithelialization. Our results have shown the efficiency of platelet-rich plasma for the treatment of intractable skin ulcers.

show abstract

“…Klosová et al reported that combination of split-thickness skin grafting (STSG) and autologous platelet concentrate reversed the viscoelastic properties of scars to the plateau state more rapidly than areas treated with STSG alone [77][78][79].…”

Section: Prp In Burnsmentioning

confidence: 99%

Platelet-Rich Plasma in Burn Treatment

Ünal¹

2018

Hot Topics in Burn Injuries

View full text Add to dashboard Cite

As a general definition, platelet-rich plasma (PRP) is the concentration of autologous human platelets in a small amount of plasma. PRP contains important growth factors deposited in alpha-granules of platelets and plasma proteins such as fibrin, fibronectin, and vitronectin. PRP has been shown to improve wound healing process in acute trauma wounds, incisional wounds, and chronic nonhealing wounds and is a beneficial agent in reconstructions of soft and hard tissue. Furthermore, PRP enhances differentiation of epithelial cell and collagen bundle organization. Effects of growth factors in PRP on wound healing and successful results obtained with PRP treatment in other types of wound lead to the use of PRP for burn treatment.

show abstract

Platelet-rich plasma promotes epithelialization and angiogenesis in a splitthickness skin graft donor site

Cited by 56 publications

References 17 publications

Clinical Safety and Efficacy of Platelet-Rich Plasma in Wound Healing

Clinical Safety and Efficacy of Platelet-Rich Plasma in Wound Healing

The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series

Platelet-Rich Plasma in Burn Treatment

Contact Info

Product

Resources

About