Platelet-Rich Plasma Versus Tretinoin in Treatment of Striae Distensae: A Comparative Study

Gamil, Hend; Ibrahim, Samia; Ebrahim, Howyda Mohamed; Albalat, Waleed

doi:10.1097/dss.0000000000001408

Cited by 29 publications

(33 citation statements)

References 19 publications

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“…Skin biopsies were taken before and 2 months after the last treatment only in selected patients. Histologically, collagen bundles and elastic fibres were increased, but no further differences were discussed in the report 15 …”

Section: Resultsmentioning

confidence: 73%

“…Six studies were included. The main findings were that multiple (≥3) repeated intradermal PRP injections for stretch marks appear to be a safe treatment modality with only initial minor side effects like transient bruising or pain during injection 5,6,13‐15 . The single report describing post‐inflammatory hyperpigmentation was most likely a result of the combination of PRP with laser therapy 16 …”

Section: Discussionmentioning

confidence: 99%

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Platelet‐rich plasma for striae distensae: What do we know about processed autologous blood contents for treating skin stretchmarks?—A systematic review

Sawetz

Lebo

Nischwitz

et al. 2021

International Wound Journal

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Striae distensae, also known as stretch marks, particularly associated with female sex, pregnancy, obesity, and/or hormonal change, are linear bands of benign dermal lesions. Although not posing any health risk, aesthetically unpleasing stretch marks can cause significant psychological distress among those affected. In abundance of therapeutic approaches, some literature sources proclaim platelet‐rich plasma to be a promising treatment modality for striae distensae. We aimed to shed some light on the current literature evidence of platelet‐rich plasma for treating stretch marks and performed an English literature analysis with two independent reviewers in accordance with PRISMA guidelines searching the PubMed and Web of Science databases in June 2019. Of the 12 found studies, 6 matched inclusion criteria. With no control groups in two, just two other reports used intraindividual comparisons, and all but one publication performed histopathological assessments. All studies observed clinical and subjective improvements without using validated scores or patient‐reported outcome measures (PROMs). The main findings were that multiple treatments with platelet‐rich plasma demonstrated increased epidermal thickness, rete ridges formation, and collagen/elastin formation, while decreasing the inflammatory cell infiltrate. The current literature evidence supporting the use of platelet‐rich plasma for striae distensae is poor. We propose in this review an outline for a study protocol with intraindividual control groups, standardised scores, validated PROMs, and participant incentives to enhance the scientific power in future clinical trials.

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Section: Resultsmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Platelet‐rich plasma for striae distensae: What do we know about processed autologous blood contents for treating skin stretchmarks?—A systematic review

Sawetz

Lebo

Nischwitz

et al. 2021

International Wound Journal

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“…Platelet-rich plasma was also compared to tretinoin cream in 30 patients with SD. 20 For each patient, half of selected SD were treated with either intralesional PRP at 4-week intervals or tretinoin 0.05% cream nightly for 3 months. Of all SD, 60% were striae alba and 40% were striae rubra.…”

Section: Prp Monotherapymentioning

confidence: 99%

Utility of platelet‐rich plasma for treatment of striae distensae: A current exploration

Heitmiller

Wang

Murgia

et al. 2020

J of Cosmetic Dermatology

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Platelet‐rich plasma (PRP) has recently become a popular treatment for various skin conditions, including striae distensae, acne scars, traumatic scars, hair regrowth, and cutaneous rejuvenation. Although PRP has been utilized in orthopedics for many years, its recent entry into dermatology has been met with controversy. While the recent research has generally been limited and is often contradictory, this has differed from the persuasive marketing campaigns targeting patients and consumers. Aesthetic practitioners should be knowledgeable with the available evidence for PRP in the treatment of striae distensae. Here, we review the pertinent literature and offer additional insights.

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“…In a split comparative study of PRP versus carboxytherapy done once a month in 20 patients of SA by Hodeib et al [69] both were found effective; with carboxytherapy being superior to PRP. Gamil et al [70] in a comparative study of PRP versus 0.1% tretinoin cream found it to be more effective than tretinoin for SA. However, this is a recent modality and the results need to be confirmed in larger studies.…”

Section: Copper-bromide Lasermentioning

confidence: 99%

Striae distensae treatment review and update

Lokhande

Mysore²

2019

Indian Dermatol Online J

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Striae distansae (SD) or stretch marks are very common, asymptomatic, skin condition frequently seen among females between 5 to 50 years of ages. It often causes cosmetic morbidity and psychological distress, particularly in women and in certain professions where physical appearances have significant importance. Of late, with the increasing emphasis on cosmetic management and awareness, patients approach dermatologists for stretch marks treatment. However, despite several advances, no fully effective treatment has emerged. Unfortunately, there is paucity of the strong evidence in the literature for the effective treatment of striae. A literature search using the terms 'striae distansae (SD or stretch marks’ was carried out in the PubMed, Google Scholar and Medline databases. Only articles related to the treatment were considered and analysed for their data. Commonly cited treatments include topical treatments like tretinoin, glycolic acid, ascorbic acid and various lasers including (like) carbon dioxide, Er:YAG, diode, Q-switched Nd:YAG, pulse dye and excimer laser. Other devices like radiofrequency, phototherapy and therapies like platelet rich plasma, chemical peeling, microdermabrasion, needling, carboxytherapy and galvanopuncture have also been used with variable success. This article reviews all currently accepted modalities and their effectiveness in the treatment of stretch marks.

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Platelet-Rich Plasma Versus Tretinoin in Treatment of Striae Distensae: A Comparative Study

Abstract: PRP injection and topical tretinoin are safe for the treatment of SD, but PRP is more effective and it gives better therapeutic response than tretinoin.

Cited by 29 publications

References 19 publications

Platelet‐rich plasma for striae distensae: What do we know about processed autologous blood contents for treating skin stretchmarks?—A systematic review

Platelet‐rich plasma for striae distensae: What do we know about processed autologous blood contents for treating skin stretchmarks?—A systematic review

Utility of platelet‐rich plasma for treatment of striae distensae: A current exploration

Striae distensae treatment review and update

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