Platelet-Rich Plasma With an Activator: A New Approach for Treating Thin Endometriums of Women Suffering From Infertility

Abstract

This case study reflects the primary infertility treatment which was in vitro fertilization (IVF) that lasted for four years. This case study involves a 37-year-old female who underwent intrauterine insemination (IUI), recurrent implantation failure, and frozen embryo transfers with a focus on platelet-rich plasma (PRP) for receptor endometrial thickness. The patient's report revealed a hormonal imbalance and a thin endometrium measuring 5 mm, while her husband's semen analysis findings were normal. Activation with calcium chloride PRP therapy successfully helped to achieve an endometrial thickness of 7.1 millimeters, and then, on the second day of the menstrual cycle, gonadotropin-releasing hormone (GnRH) was given. Six oocytes were retrieved, and after intracytoplasmic sperm injection (ICSI), a good-quality blastocyst was developed. On day 21 of the cycle, an embryo of 4AB grade was transferred. Serum beta-human chorionic gonadotropin (β-hCG) was positive, which confirmed pregnancy 14 days after the process of embryo transfer. The patient was advised to take regular check-ups during pregnancy. Recurrent implantation failure and thin endometrium are critical issues in this case, demonstrating that PRP can be used to augment the endometrial thickness to improve the pregnancy rate.