1991
DOI: 10.1017/s0924933800000857
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Platelet serotonin binding and plasma cortisol in panic disorder before and after alprazolam plus behavioral guidance treatment

Abstract: SummaryIn 32 patients with panic disorder with or without agoraphobia, Bmax measures of 5-HT binding in platelets did not differ from normal controls at baseline. Plasmatic cortisol levels were significantly higher than controls in the morning and in the evening measures as well as in post-dexamethasone assays. Following an 8-week treatment period with alprazolam plus behavioral guidance encouraging exposure, Bmax values did not alter but cortisol measures diminished significantly. Measures of phobic avoidance… Show more

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