Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms

Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder

“…However, in the present and our previous studies Pivac et al, 2002;Pivac et al, 2006a;Pivac et al, 2006b), as well as in work from other groups (Maguire et al, 1998;Mellman and Kumar, 1994;Cicin-Sajn et al, 2000), platelet 5-HT concentration was similar between PTSD patients and corresponding control subjects. These data confirm our hypothesis that the reduced platelet 5-HT concentration in suicidal veterans with combat related PTSD is a trait marker, predictive of suicidal behavior in PTSD.…”

“…If platelet 5-HT concentration had differed significantly between non-suicidal patients with PTSD and healthy control group, the significance of the altered platelet 5-HT concentration in suicidal behavior would be difficult to explain, since altered platelet 5-HT concentration might be related to the presence of psychotic symptoms such as delusions (Pivac et al, 2006a), severe appetite loss , or some other traits in PTSD patients.…”

Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer's disease

“…Increased (Meszaros et al 1998;Nicotra et al 2004) or unchanged (Pivac et al 2006a) platelet MAO-B activity was found in healthy controls during aging. Since MAO is a mitochondrial enzyme, it is possible that altered MAO-B activity in AD might be a consequence of the changes in the structure of the mitochondrial membrane occurring during aging (Nicotra et al 2004).…”

“…It has been reported that lower platelet MAO-B activity might be induced by smoking (Oreland, 2004;Pivac et al 2006aPivac et al , 2007 and chronic alcohol abuse (Oreland, 2004). To exclude the effect of smoking, all female subjects included in the study were nonsmokers.…”

“…Therefore, the hypothesis of the present study was that these platelet biochemical markers would correlate with the cognitive indices of severity in AD. As both markers, platelet 5-HT concentration (Muck-Seler et al, 1996 and platelet MAO-B activity (Mimica et al 2005;Pivac et al 2005) are under influence of sex, and platelet MAO-B activity is affected by smoking (Oreland, 2004;Pivac et al 2006a), the study included only female non-smoking subjects. The aim of the study was to determine platelet 5-HT concentrations and platelet MAO-B activity in patients with probable AD and control subjects, and in patients subdivided according to the severity of dementia into groups of patients in early, middle and late phase of AD.…”