Platelet-to-albumin ratio: a risk factor associated with technique failure and mortality in peritoneal dialysis patients

Yang, Yuqi; Yuan, Jing; Liu, Lu; Qie, Shuwen; Yang, Li; Zha, Yan

doi:10.1080/0886022x.2021.1977319

Cited by 14 publications

(10 citation statements)

References 25 publications

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“…PAR was also illustrated to predict the mortality of patients suffering from severe fever with thrombocytopenia syndrome ( 17 ). PAR plays a similar role in predicting outcomes of patients with peritoneal dialysis ( 18 ). Hence, the consistent results of multiple articles suggested that the PAR might become a novel prognostic indicator in the future ( 4 , 5 , 16 – 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…PAR plays a similar role in predicting outcomes of patients with peritoneal dialysis ( 18 ). Hence, the consistent results of multiple articles suggested that the PAR might become a novel prognostic indicator in the future ( 4 , 5 , 16 – 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, PAR is a combination marker that seems to be more accurate in prediction than other platelet-related parameters. It has been reported that PAR might be more stable and less likely to be affected by dynamic physiological conditions than other platelet parameters and/or inflammatory markers ( 17 , 18 , 26 , 27 ). As PAR seemed to be related to the inflammatory responses, it would be crucial to show whether PAR was correlated with one of the most used inflammatory serum markers such as the C-reactive protein (CRP).…”

Section: Discussionmentioning

confidence: 99%

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Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

et al. 2022

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BackgroundChronic inflammation is related to the development of IgA nephropathy (IgAN). Emerging studies have reported that platelet-related parameters including platelet (PLT), platelet-to-albumin ratio (PAR), and platelet-to-lymphocyte ratio (PLR) are proved to be novel prognostic indicators for several inflammatory diseases. Whether platelet-related parameters could serve as predictors for IgAN remains unknown.MethodsA total of 966 IgAN patients were enrolled in this retrospective study and were divided into several groups based on the optimal cut-off value of the platelet-related parameters. End-stage renal disease was used as the renal endpoint. A 1:2 propensity score (PS) match was then carried out to eliminate significant differences at baseline. The area under the receiver operating characteristic curve (AUROC), Kaplan–Meier (K-M) curve, and Cox proportional hazards analyses were performed to evaluate their predictive effect.ResultsWithout considering the effect of covariates, the K-M curve showed that PLT, PLR, and PAR were strongly correlated with the renal outcomes of IgAN. However, the AUROC revealed that the PAR and PLR had better predictive power than the PLT. Multivariate Cox regression adjusting for demographic data, pathological findings, treatment, and laboratory results indicated that compared with PLR, albumin and PLT, PAR seemed to be a better marker of adverse renal outcome, implying that PAR was the only platelet-related parameter that could be used as an independent risk factor. Notably, high PAR patients seemed to have more severe clinical manifestations and pathological lesions. However, after eliminating the influence of different baselines on outcome variables, the PAR could still predict the poor prognosis of IgAN. To more accurately evaluate the predictive power of the PAR, we analyzed the predictive effect of the PAR on patients with different clinicopathological characteristics through subgroup analysis. It was indicated that the PAR might better predict the prognosis and outcome of patients whose disease was already very severe.ConclusionPAR might be used as an independent risk factor for IgAN progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

et al. 2022

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“…Several clinical investigations have gained insight into the prognostic value of PAR. Yang et al [ 20 ] performed a single-center study with 405 peritoneal dialysis patients and reported that PAR was a risk factor associated with mortality. Moreover, PAR not only contributed to critical illness but was also implicated in the risk assessment of a list of malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Utility of Platelet-to-Albumin Ratio among Critically Ill Patients with Colorectal Cancer: A Propensity Score Matching Study

Wang

et al. 2022

Journal of Oncology

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The platelet-to-albumin ratio (PAR) was developed to evaluate inflammatory and nutritional status among patients. The primary goal of the current study was to gain insight into the prognostic role of PAR in critically ill patients with colorectal cancer (CRC). The secondary aim was to develop and verify a clinical model including PAR for the prediction of 28-day mortality. This observational, multicenter study used data from the Medical Information Mart for Intensive Care (MIMIC) IV, e-ICU databases, and Union cohort. Data from 776 critically ill patients with CRC were from the e-ICU database, 219 from the MIMC-IV database, and 135 from the Wuhan Union Hospital. Propensity score matching (PSM) analysis, along with inverse probability treatment weighting, was used to control the influence of confounding factors. Support vector machine (SVM) and LASSO Cox models were then applied to identify significant metrics associated with 28-day mortality in the test cohort. Receiver operating curve (ROC) analysis, along with sensitivity and specificity, was measured to assess the predictive performances of PAR and the survival nomogram. The threshold value for PAR was 8.6, and patients with high PAR (≥8.6) experienced higher 28-day mortality compared to those with low PAR (<8.6). ROC curve analyses revealed that the discriminative ability of PAR was better than platelet count and albumin alone. LASSO Cox regression along with SVM identified six significant metrics associated with 28-day mortality in critically ill patients with CRC, including PAR. The C-index of the critically ill CRC nomogram was 0.802 (0.744–0.859) in the e-ICU training cohort, 0.839 (0.779–0.899) in the e-ICU validation cohort, 0.787 (0.695–0.879) in the MIMIC-IV cohort, and 0.767 (0.703–0.831) in the Union cohort. PAR is a simple score that combines inflammatory and nutritional status. PAR was a reliable index to predict short-term survival outcome of critically ill patients with CRC. Moreover, a clinical nomogram incorporating PAR exhibited satisfactory performance for predicting 28-day mortality of critically ill patients with CRC.

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“…13 Relationships between platelet ratio and chronic obstructive pulmonary disease, acute aortic dissection, peritoneal dialysis, haemodialysis, and severe pneumonia have been reported in numerous studies. [14][15][16][17][18] Decreased platelet count in severe disease is a predictor of mortality. 19 This suggests that platelet ratio may be used as a tool for predicting the prognosis of patients with AMI.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database

Liu

Shen

et al. 2022

BMJ Open

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ObjectivesWe aimed to investigate the association between red cell distribution width-to-platelet ratio (RPR), and in-hospital mortality in critically ill patients with acute myocardial infarction (AMI).DesignA retrospective cohort study.SettingData were collected from the Medical Information Mart for Intensive Care database (MIMIC-IV) consisting of critically ill participants between 2008 and 2019 at the Beth Israel Deaconess Medical Centre in Boston.ParticipantsA total of 5067 patients with AMI were enrolled from the MIMIC-IV database.Primary and secondary outcomeIn-hospital mortality.ResultsA total of 4034 patients survived, while 1033 died. In a multiple regression analysis adjusted for age, weight and ethnicity, RPR also showed a positive correlation with in-hospital mortality (HR 1.91, 95% CI 1.42 to 2.56, p<0.0001). Moreover, after adjusting for additional confounding factors, obvious changes were observed (HR 1.63, 95% CI 1.03 to 2.57, p=0.0357). In model 2, the high ratio quartile remained positively associated with hospital mortality compared with the low ratio quartile (HR 1.20, 95% CI 1.01 to 1. 43), with a p-value trend of 0.0177. Subgroup analyses showed no significant effect modifications on the association between RPR and in-hospital mortality in the different AMI groups (p>0.05).ConclusionRPR is an independent predictor of in-hospital mortality in critically ill patients with AMI.

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Platelet-to-albumin ratio: a risk factor associated with technique failure and mortality in peritoneal dialysis patients

Cited by 14 publications

References 25 publications

Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

Prognostic Utility of Platelet-to-Albumin Ratio among Critically Ill Patients with Colorectal Cancer: A Propensity Score Matching Study

Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database

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