Platelet‐to‐lymphocyte ratio and prognosis in STEMI: A meta‐analysis

Dong, Guoxia; Huang, Aiqin; Liu, Lei

doi:10.1111/eci.13386

“…However, there is growing evidence for the role of inflammation in development and persistence of atrial fibrillation [ 47 ]. In a meta-analysis performed by Dong et al in STEMI patients, it was observed that a high PLR predicts poor in-hospital and long-term prognosis in patients undergoing PCI [ 48 ]. Several retrospective and prospective studies in patients with STEMI found that a high PLR was a predictor of no-reflow phenomenon in patients undergoing PCI [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Value of Hematological and Coagulation Parameters as Prognostic Factors in Acute Coronary Syndromes

Babeş

¹

,

Zaha

²

,

Ţiţ

³

et al. 2021

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The values of hematological and coagulation biomarkers were evaluated as predictors of in hospital mortality and complications, in patients with acute coronary syndromes (ACS). This retrospective observational study enrolled 936 ACS subjects admitted to the Clinical Emergency Hospital of Oradea, Romania, between January–December 2019. Hematological and coagulation parameters were obtained at admission. During hospitalization, the following adverse events were recorded: death, ventricular rhythm disturbances, atrial fibrillation, heart failure, re-infarction, and stroke. Accuracy of hematological and coagulation parameters as predictors of adverse outcome were also evaluated. The diagnosis was unstable angina in 442 patients (47.22%), non-ST-elevation myocardial infarction (NSTEMI) in 113 patients (12.1%) and ST-elevation myocardial infarction (STEMI) in 381 patients (40.70%); 87 patients (9.29%) died during hospitalization and 193 (20.7%) developed complications. Predictors for in hospital mortality were as follows: red cell distribution width (RDW) (AUC 0.691, p < 0.0001), white blood cells (WBC) (AUC 0.684, p < 0.0001), neutrophils (NEU) (AUC 0.684, p < 0.0001), and prothrombin time (PT) (AUC 0.765, p < 0.0001). WBC (AUC 0.659, p < 0.0001), NEU (AUC 0.664, p < 0.0001), RDW (AUC 0.669, p < 0.0001), and PT (AUC 0.669, 95% CI 0.622–0.714, p < 0.0001) also had accuracy for complications prediction. RDW had a good ability to predict heart failure in NSTEMI patients (AUC 0.832, p < 0.0001). An acceptable ability to predict ventricular rhythm disturbances occurrence had WBC (AUC 0.758, p < 0.0001) and NEU (AUC 0.772, p < 0.0001). Hematological and coagulation parameters can help in risk stratification of ACS patients. RDW, WBC, NEU, and PT were able to predict mortality and in-hospital complications in ACS patients. RDW has a good accuracy in predicting complications and heart failure in NSTEMI patients. WBC and NEU are good predictors for ventricular rhythm disturbances.

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“…It has been studied in several chronic inflammatory diseases and had a significant predictor of outcomes. [15][16][17][18] There is an increasing evidence that simple inflammatory biomarkers as P/LR as well as neutrophil to lymphocyte ratio (N/LR) can act as reliable predictors of a variety of medical conditions such as brain infarct, cerebral hemorrhage, and acute coronary syndrome [19][20][21]. The higher preprocedural P/LR predicts the shortand long-term prognosis after percutaneous revascularization interventions [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Platelet to Lymphocyte Ratio Associated with Prolonged Hospital Length of Stay Postpeptic Ulcer Perforation Repair: An Observational Descriptive Analysis

Al‐Yahri

¹

,

Saafan

²

,

Abdelrahman

³

et al. 2021

BioMed Research International

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Background. The predictive role of platelet to lymphocyte ratio (P/LR) in patients with perforated peptic ulcer (PPU) is not well-studied. We aimed to investigate the association between the P/LR ratio and the hospital length of stay (HLOS) for surgically treated PPU. Method. This is a retrospective observational study for surgically treated adult cases of PPU at Hamad Medical Corporation during the period from January 2012 to August 2017. Patients were categorized into two groups based on their HLOS (<I week vs. >I week). The receiver operating characteristic (ROC) curve was plotted to determine the cutoff value for lymphocyte count, neutrophil to lymphocyte ratio, and P/LR ratio for predicting the prolonged hospitalization. Results. One hundred and fifty-two patients were included in the study. The majority were young males. The mean age was 38.3 ± 12.7 years. Perforated duodenal ulcer (139 patients) exceeded perforated gastric ulcer (13 patients). The HLOS > 1 week was observed in 14.5% of cases. Older age ( p = 0.01 ), higher preoperative WBC ( p = 0.03 ), lower lymphocyte count ( p = 0.01 ), and higher P/LR ratio ( p = 0.005 ) were evident in the HLOS > 1 week group. The optimal cutoff value of P/LR was 311.2 with AUC 0.702 and negative predictive value of 93% for the prediction of prolonged hospitalization. Two patients died with a mean P/LR ratio of 640.8 ± 135.5 vs. 336.6 ± 258.9 in the survivors. Conclusion. High preoperative P/LR value predicts prolonged HLOS in patients with repaired perforated peptic ulcer. Further larger multicenter studies are needed to support the study findings.

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“…Given the established relationship between IPF condition and some inflammation biomarkers [ 20 , 21 , 23 , 24 , 25 , 26 , 27 , 28 ], we sought to determine the prognostic capacity of the combined blood cell count indexes, a group of well-recognized biomarkers of inflammation obtained by the complete blood cell count test, that is routinely provided in clinical practice. Ratios of blood cell counts have shown to be effective in predicting the survival of those with acute and chronic diseases [ 29 , 30 , 31 , 32 , 33 , 34 ]. Similar properties have also been exhibited by some blood cell dimensional indexes, such as the red blood cell distribution width (RDW), which has been reported to be an indicator of poor prognosis in IPF [ 10 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Aggregate Index of Systemic Inflammation (AISI): A Novel Prognostic Biomarker in Idiopathic Pulmonary Fibrosis

Zinellu

¹

,

Collu

²

,

Nasser

³

et al. 2021

JCM

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Variable patterns of disease progression are typically observed in patients with idiopathic pulmonary fibrosis (IPF). We sought to determine the prognostic capacity of blood cell count indexes, derived from routine complete blood cell (CBC) count, in a cohort of IPF patients. The neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) were calculated at baseline in a consecutive series of 82 IPF patients followed for four years. After adjusting for age, gender, body mass index, smoking status, and disease stage, only the AISI was significantly associated with mortality (HR 1.0013, 95% CI 1.0003–1.0023, p = 0.015). Patients with AISI <434 and ≥434 had a median survival from the diagnosis of 35.3 ± 15.2 and 26.6 ± 16.3 months (p = 0.015), and a four-year survival rate of 54% and 34%, respectively. The AISI, easily derivable from routine laboratory tests, is independently associated with mortality in patients with IPF. Prospective studies in larger cohorts are required to confirm this association.

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Platelet‐to‐lymphocyte ratio and prognosis in STEMI: A meta‐analysis

Cited by 55 publications

References 49 publications

Value of Hematological and Coagulation Parameters as Prognostic Factors in Acute Coronary Syndromes

Value of Hematological and Coagulation Parameters as Prognostic Factors in Acute Coronary Syndromes

Platelet to Lymphocyte Ratio Associated with Prolonged Hospital Length of Stay Postpeptic Ulcer Perforation Repair: An Observational Descriptive Analysis

The Aggregate Index of Systemic Inflammation (AISI): A Novel Prognostic Biomarker in Idiopathic Pulmonary Fibrosis

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