Platelet to lymphocyte ratio in the prediction of adverse outcomes after acute coronary syndrome: a meta-analysis

Abstract

Recent studies have shown platelet to lymphocyte ratio (PLR) to be a potential inflammatory marker in cardiovascular diseases. We performed a meta-analysis to systematically evaluate the prognostic role of PLR in acute coronary syndrome (ACS). A comprehensive literature search up to May 18, 2016 was conducted from PUBMED, EMBASE and Web of science to identify related studies. The risk ratio (RR) with 95% confidence interval (CI) was extracted or calculated for effect estimates. Totally ten studies involving 8932 patients diagnosed with ACS were included in our research. We demonstrated that patients with higher PLR level had significantly higher risk of in-hospital adverse outcomes (RR = 2.24, 95%CI = 1.81–2.77) and long-term adverse outcomes (RR = 2.32, 95%CI = 1.64–3.28). Sensitivity analyses confirmed the stability of our results. We didn’t detect significant publication bias by Begg’s and Egger’s test (p > 0.05). In conclusion, our meta-analysis revealed that PLR is promising biomarker in predicting worse prognosis in ACS patients. The results should be validated by future large-scale, standard investigations.

Association of platelet-to-lymphocyte count ratio with myocardial reperfusion and major adverse events in patients with acute myocardial infarction: a two-centre retrospective cohort study

“…Studies have shown that decreased lymphocyte count was associated with increased mortality in patients with AMI 12–14. Previous studies have found that platelet-to-lymphocyte ratio (PLR) can be used as a predictor of long-term mortality and is an independent risk factor for no reflow after PPCI and increased mortality in hospital, and the increase in PLR is positively correlated with the 6-month all-cause mortality in ST-elevation myocardial infarction (STEMI) patients 15–18…”

Analysis of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean platelet volume to platelet count ratio in children with acute stage of immunoglobulin A vasculitis and assessment of their suitability for predicting the course of the disease

“…The shifts in the percentage formula of white blood cells (neutrophilia and lymphopenia) are the physiological response of the immune system to the ongoing inflammatory process, injury or stress [4], and NLR and PLR reflect these changes. Until now, their relationship with the severity of the disease and/or prognosis in patients with autoimmune diseases, malignancies, cardiovascular and respiratory diseases, and in the pediatric population also in allergic diseases such as bronchial asthma or atopic dermatitis were studied [5][6][7][8][9][10][11]. Few studies indicate significant differences in NLR and PLR values in IgAV patients compared to healthy subjects.…”

Association between inflammatory markers and primary hyperparathyroidism

“…Systemic inflammation has a role in the progression and recurrence of solid tumors [16]. PLR and RDW values have been shown to be associated with the diagnosis and prognosis of several inflammatory disorders and malignancies [11,17,18]. In patients with secondary hyperparathyroidism, PLR and platelet count decreased after parathyroidectomy; however, these parameters were not significantly decreased in recurrent or persistent hyperparathyroidism [4].…”