Platelet to lymphocyte ratio is associated with the severity of coronary artery disease and clinical outcomes of percutaneous coronary intervention in the Chinese Han population

Abstract

Abstract. The aim of the present study was to evaluate whether the ratio of the absolute number of platelets to the number of lymphocytes (PLR) correlates with the severity of coronary artery disease (CAD) and major adverse cardiovascular disease (CVD) events in Chinese patients with CAD. PLR was calculated as follows: PLR=platelet count/lymphocyte count, using the complete blood counts of 854 Chinese Han subjects. CAD severity was determined using angiographic evidence by cardiologists unaware of the study aims. The association between PLR and CAD severity was analyzed by logistic regression. Clinical endpoints were evaluated during a median follow-up period of 42 months. The association between PLR and CVD events was assessed using Cox regression models. Patients with PLR>171 exhibited more severe coronary artery stenosis [odds ratio, 2.393; 95% confidence intervals (CI), 1.394-4.108; P=0.002] and worse prognoses, with a higher rate of major adverse CVD events during five years of follow-up (hazard ratio, 1.982; 95% CI, 1.329-2.957; P=0.001).A Kaplan-Meier curve demonstrated that the CVD event rate of 34.27% in patients with PLR>171 was significantly higher than that in patients with PLR<100 (P<0.001). These findings suggest that PLR is independently associated with CAD severity and long-term major adverse CVD events; therefore, high PLR may predict poor prognosis of CAD in the Chinese Han population.

The importance of hemogram parameters in family medicine for coronary artery disease

“…[8] PLR may act as an effective biomarker to predict CVD and the risk of future CVD events. [10] In our study, we found that as the mean PLR increased, the stenosis grade also increased. The mean PLR level in the control group was lower than in the patient group, but there was no statistical significance.…”

Platelet to lymphocyte ratio in acute aortic dissection

“…Our best cutoff value of PLR with a high degree of specificity but fairly low sensitivity was 159; of note, PLR > 150 was associated with an odds ratio of 1.9 for critical limb ischemia in patients with peripheral arterial disease . In addition, preoperative PLR > 142 was observed in coronary patients with post‐coronary bypass grafting complications, PLR > 128 was an independent predictor of future events in patients with NSTEMI, and PLR > 171 in patients with stable CAD was associated with more severe coronary disease and worse prognosis . PLR is, therefore, a novel parameter which indicates inflammation and carries prognostic significance in a variety of clinical conditions.…”

Association Between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio With 1-Year Mortality in Hemodialysis Patient in Wangaya Regional General Hospital

“…Zhou et al in their study showed that PLR is independently associated with CAD severity and long-term major adverse CVD events. This might explain higher incidence of mortality in our patients with higher PLR [12].…”