Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR), and eosinophil-to-lymphocyte ratio (ELR) as biomarkers in patients with acute exacerbation chronic obstructive pulmonary disease

Abstract

The study comprehensively evaluated the prognostic roles of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio. (MLR), basophil-to-lymphocyte ratio (BLR) and eosinophil-to-lymphocyte ratio (ELR) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). 619 patients with AECOPD and 300 healthy volunteers were retrospectively included into the study. The clinical characteristics containing laboratory findings of the AECOPD patients and the complete blood counts (CBCs) of the healthy volunteers were collected. Compared with the healthy volunteers, PLR, NLR, MLR, BLR, and ELR were all elevated in COPD patients under stable condition. PLR, NLR, MLR, and BLR were further elevated while ELR was lowered during exacerbation. PLR, NLR, and MLR were all positively correlated with hospital LOS as well as CRP. In contrast, ELR was negatively correlated with hospital LOS as well as CRP. Elevated PLR, NLR, and MLR were all associated with more serious airflow limitation in AECOPD. Elevated PLR, NLR, and MLR were all associated with increased in-hospital mortality while Elevated ELR was associated with decreased in-hospital mortality. Binary logistic regression analysis showed that smoking history, FEV1% predicted, pneumonia, pulmonary heart disease (PHD), uric acid (UA), albumin, and MLR were significant independent predictors for in-hospital mortality. These predictors along with ELR were used to construct a nomogram predicting in-hospital mortality in AECOPD. The nomogram had a C-index of 0.850 (95% CI: 0.799–0.901), and its good predictive value and clinical applicability were summary further demonstrated. In summary, PLR, NLR, MLR, and ELR served as biomarkers in patients with AECOPD.

Evaluation of the prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)

“…Unlike PLR, NLR, and MLR, ELR was identi ed to be a favourable prognostic factor in AECOPD. Namely, elevated ELR was associated with better clinical outcomes, such as reduced hospital LOS as well as inhospital mortality, and alleviated air ow limitation [3]. In this study, increased ELR was associated with improved OS and reduced ICU admission rates, and ELR was positively correlated with hospital LOS as well as ICU LOS.…”

“…To our best knowledge, this was the rst study to evaluate the prognostic value of the systemic in ammatory factors (PLR, NLR, MLR, BLR, and ELR) in patients with SCAP. BLR is a rarely studied disease biomarker, a recent study on the association of systemic in ammatory factors (PLR, NLR, MLR, BLR, and ELR) with clinical outcomes in patients with AECOPD revealed that only BLR had no association with the clinical outcomes involving hospital LOS, air ow limitation, and in-hospital mortality [3].…”

“…In recent years, increased studies found that systemic in ammatory factors including platelet-tolymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) served as biomarkers in respiratory disease, such as acute exacerbation chronic obstructive pulmonary disease (AECOPD) [3], non-small cell lung cancer (NSCLC) [4], pulmonary brosis [5], and coronavirus disease 2019 (COVID-19) [6,7]. For instance, elevated PLR, NLR, and MLR were all associated with increased hospital length of stay (LOS) and in-hospital mortality as well as exacerbated air ow limitation…”

Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)

“…Namely, elevated ELR was associated with better clinical outcomes, such as reduced hospital LOS as well as inhospital mortality, and alleviated air ow limitation. 3 In this study, increased ELR was associated with improved OS and reduced ICU admission rates, and ELR was positively correlated with hospital LOS as well as ICU LOS. Moreover, ELR were lowered in patients with SCAP compared to healthy volunteers, and improved when the patients were in recovery after treatment.…”

“…BLR is a rarely studied disease biomarker, a recent study on the association of systemic in ammatory factors (PLR, NLR, MLR, BLR, and ELR) with clinical outcomes in patients with AECOPD revealed that only BLR had no association with the clinical outcomes involving hospital LOS, air ow limitation, and in-hospital mortality. 3 Nevertheless, this study found that BLR was served as an important biomarker in SCAP. In patients with SCAP, elevated BLR was associated with increased in-hospital mortality, ICU admission rates, and ICU mortality.…”