Platelet-to-neutrophil ratio is a prognostic marker for 90-days outcome in acute ischemic stroke

Jin, Pingping; Li, Xian‐Mei; Chen, Jie; Zhang, Zeng-Rui; Hu, Wangwang; Chen, LuYun; Feng, Xiaowen; Shao, Baiqi

doi:10.1016/j.jocn.2019.01.028

Cited by 49 publications

(47 citation statements)

References 40 publications

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“… 20 Chen et al have found in their research that lower PNR level was associated with poor 3 months outcomes and suggested that PNR level might be an autocephaly protective predictor of 90-days outcome in AIS patients. 21 SII, combining platelet counts and leukocytes subpopulations, represented the systemic immune-inflammation status and was proved in many studies to be related to major adverse events. 22 In the following sections, we are going to discuss the influence platelets, neutrophils and lymphocytes have on stroke and the interaction mechanism of them.…”

Section: Discussionmentioning

confidence: 99%

Systemic Immune-Inflammation Index Predicts 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

Weng

Zeng

Huang

et al. 2021

CIA

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Background and Purpose Systemic immune-inflammation index (SII), a novel inflammation index derived from counts of circulating platelets, neutrophils and lymphocytes, has been studied in developing incident cancer. However, the clinical value of SII in acute ischemic stroke (AIS) patients had not been further investigated. Therefore, we aimed to explore the association between SII and severity of stroke as well as 3-month outcome of AIS patients. Methods A total of 216 AIS patients receiving intravenous thrombolysis (IVT) and 875 healthy controls (HCs) were retrospectively recruited. Blood samples were collected within 24h after admission. Severity of stroke was assessed by the National Institute of Health stroke scale (NIHSS) scores on admission and poor 3-month functional outcome was defined as Modified Rankin Scale (mRS) > 2. Results SII levels in AIS patients were higher than in HCs. The cut-off value of SII is 545.14×10 9 /L. Patients with SII > 545.14×10 9 /L had higher NIHSS scores (median: 5 vs 9, p < 0.001), a positive correlation between SII and NIHSS was observed ( rs = 0.305, p < 0.001). Multivariate logistic regression analyses showed that high SII was one of the independent risk factors for poor prognosis at 3 months of AIS patients (OR = 3.953, 95% CI = 1.702–9.179, p = 0.001). The addition of SII to the conventional prognostic model improved the reclassification (but not discrimination) of the functional outcome (net reclassification index 39.3%, p = 0.007). Conclusion SII is correlated with stroke severity at admission and can be a novel prognostic biomarker for AIS patients treated with IVT.

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Section: Discussionmentioning

confidence: 99%

Systemic Immune-Inflammation Index Predicts 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

Weng

Zeng

Huang

et al. 2021

CIA

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“…For example a study on colorectal cancer and neutrophil-platelet score (NPS) showed that highest NPS score present a worse outcome as also high correlation with CRP and serum albumin the authors hypothesized that this score could be an inflammatory systemic marker and that had also clinical utility in other types of cancer like breast, bladder, and prostate [22]. In the ischemic stroke, it is well taken as a survival marker to 90 days as it has been demonstrated that a lower NeuPla ratio translates as less inflammation and necrosis due to authors conclude again that the NeuPla ratio is a tool that could measure inflammation and necrosis [12].…”

Section: Plos Onementioning

confidence: 99%

“…The interaction of neutrophil-platelet is a possible explanation of the high prevalence of thrombosis in UC due to the formation of Neutrophil Extracellular Traps (NETs) through Toll-like receptor 4 (TLR-4) [10]. A neutrophil-platelet ratio (NeuPla ratio) could be used as a monitor tool for UC, this ratio has been already used in other pathologies [12,13] and only required a complete blood count (CBC) making it an accessible, fast, easy to use and low-cost tool.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of the neutrophil-platelet ratio as a novel marker of activity in patients with Ulcerative Colitis

Yamamoto-Furusho

Mendieta-Escalante

2020

PLoS ONE

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Background Ulcerative colitis (UC) is a chronic disease characterized by periods of activity and remission. The platelet, one of the main activators of neutrophils, contains Interleukin 8 (IL-8), a potent neutrophil chemo-attractant and P-selectin that induces excretion of superoxide in the neutrophils, forming platelet-neutrophil aggregates that are increased in individuals with active UC, hence an index of both cells could produce a monitoring tool. No previous studies have evaluated this ratio in UC. Goal To evaluate the clinical utility of the Neutrophil-Platelet (NeuPla) ratio in patients with UC. Study A total of 158 patients with a diagnosis of UC. This index was based on the ratio between platelets and the neutrophil differential in blood count. The activity was classified using Mayo endoscopic sub-score, histological (Riley score) and for clinical was used the Truelove-Witts, Montreal, Mayo and Yamamoto-Furusho scores. Results The correlation of the NeuPla ratio with activity scales were significant (P <0.05). An optimal cutoff point to classify patients with clinical activity was 14.94 with a sensitivity 87.95% and specificity 63.5 and endoscopy activity with a cutoff 14.64 with a sensibility of 70.5% and specificity of 61.8%. Conclusions The NeuPla ratio showed an adequate diagnostic utility to identify UC patients with clinical and endoscopy activity without the use of invasive studies like a colonoscopy or expensive fecal biomarkers such as calprotectin and have a better diagnostic performance in

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“…Increased neutrophil count and decreased platelet count may be associated with poor functional outcome in patients with HT (22,23). A recent study found that high neutrophil-to-platelet ratio (NPR) was associated with long-term poor outcome in patients with acute ischemic stroke (24). Indeed, NPR shows its advantage in revealing information about the crosstalk between inflammation and hemostasis, and has been suggested as a useful and rapid screening tool to assess systemic inflammation in infective endocarditis (25).…”

Section: Introductionmentioning

confidence: 99%

High Neutrophil-to-Platelet Ratio Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke

Ruan

Yuan

et al. 2019

Front. Neurol.

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Background: Hemorrhagic transformation (HT) is a complication that may cause neurological deterioration in patients with acute ischemic stroke. Both neutrophil and platelet have been associated with the stroke progression. The aim of this study was to explore the relationship between neutrophil-to-platelet ratio (NPR) and HT after acute ischemic stroke. Methods: A total of 279 stroke patients with HT were consecutively recruited. HT was diagnosed using magnetic resonance imaging (MRI) or computed tomography (CT) and classified into hemorrhagic infarction (HI) and parenchymal hematoma (PH). Blood samples for neutrophil and platelet counts were obtained at admission. Meanwhile, 270 age-and gender-matched controls without HT were included for comparison. Results: Among the patients with HT, 131 patients had PH and 148 patients had HI. NPR was higher in patients with PH than those with HI or non-HT [36.8 (23.7-49.2) vs. 26.6 (17.9-38.3) vs. 19.1 (14.8-24.8), P < 0.001]. After adjustment for potential confounders, high NPR remained independently associated with the increased risk of HT (OR = 2.000, 95% CI: 1.041-3.843, P = 0.037). NPR (>39.9) was independently associated with PH (OR = 2.641, 95% CI: 1.308-5.342, P = 0.007). Conclusions: High NPR was associated with the increased risk of HT especially PH in patients with acute ischemic stroke.

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Platelet-to-neutrophil ratio is a prognostic marker for 90-days outcome in acute ischemic stroke

Cited by 49 publications

References 40 publications

Systemic Immune-Inflammation Index Predicts 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

Systemic Immune-Inflammation Index Predicts 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

Diagnostic utility of the neutrophil-platelet ratio as a novel marker of activity in patients with Ulcerative Colitis

High Neutrophil-to-Platelet Ratio Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke

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