Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)

Anthon, Carl Thomas; Pène, Frédéric; Perner, Anders; Azoulay, Élie; Louw, Andry Van de; Barret‐Due, Andreas; Chawla, Sanjay; Castro, Pedro; Póvoa, Pedro; Coelho, Luís; Metaxa, Victoria; Munshi, Laveena; Kochanek, Matthias; Liebregts, Tobias; Kander, Thomas; Hästbacka, Johanna; Møller, Morten Hylander; Russell, Lene; Hildebrandt, Thomas; Vogelius, Mette Kragh; Clausen, Niels; Bestle, Morten H.; Lorentzen, Kristian; Nielsen, Lene Bjerregaard; Andreasen, Jo Bønding; Hvas, Christine Lodberg; Juhl, Christian Svendsen; Lundqvist, Linda; Lindquist, Elin; Bådstøløkken, Per Martin; Holten, Aleksander Rygh; Kvåle, Reidar; Strand, Kristian; Klepstad, Pål; Hästbacka, Johanna; Jalkanen, Ville; Reinikainen, Matti; Péju, Edwige; Marin, Nathalie; Vimpère, Damien; Menat, Sophie; Voiriot, Guillaume; Schmidt, Julien; Dufranc, E.; Uhel, Fabrice; Lafarge, Antoine; Missri, Louaï; Ait‐Oufella, Hafid; Canet, Emmanuel; Metexa, Victoria; Puxty, Kathryn; Wright, Christopher; Costa, Carolina Cabral Pereira da; Paulino, Carolina; Graça, Carina; Torres, João Carlos Sousa; Voigt, Louis; Lueck, Catherina; Liebgrets, Tobias

doi:10.1111/aas.14124

Cited by 10 publications

(40 citation statements)

References 36 publications

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“…Approximately 40% of adult intensive care unit (ICU) patients have thrombocytopenia upon arrival to the ICU or will develop it at some point during their ICU stay. [1][2][3][4] Thrombocytopenia has been associated with an increased risk of major bleeding in adult ICU patients [5][6][7] and platelet transfusions are often used in these patients to treat or prevent bleeding. 3,4,8 This makes ICUs major consumers of platelet transfusions, with reports indicating that 5%-24% of all platelet transfusions are used in ICUs.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Thrombocytopenia has been associated with an increased risk of major bleeding in adult ICU patients [5][6][7] and platelet transfusions are often used in these patients to treat or prevent bleeding. 3,4,8 This makes ICUs major consumers of platelet transfusions, with reports indicating that 5%-24% of all platelet transfusions are used in ICUs. [9][10][11] Previous studies reporting data on the use of platelet transfusions in adult ICU patients have primarily focused on indications for platelet transfusions, pre-transfusion platelet counts and post-transfusion platelet count increments.…”

Section: Discussionmentioning

confidence: 99%

“…All necessary national/regional/local approvals were obtained as appropriate, and informed consent was sought from patients and/or relatives if required by applicable regulations. 4,29…”

Section: Ethics and Approvalsmentioning

confidence: 99%

“…All patients with thrombocytopenia (defined as platelet count <150 Â 10 9 /L at ICU admission and/or during ICU stay) enrolled in the PLOT-ICU study will be eligible for this sub-study. 4 The PLOT-ICU study enrolled adult (≥18 years of age) acutely admitted (i.e., a non-planned admission) patients regardless of diagnosis and expected length of ICU stay and excluded patients who denied informed consent, had previously been enrolled or underwent elective open-heart surgery during the hospitalisation leading to the ICU admission. 4,29…”

Section: Populationmentioning

confidence: 99%

“…4 The PLOT-ICU study enrolled adult (≥18 years of age) acutely admitted (i.e., a non-planned admission) patients regardless of diagnosis and expected length of ICU stay and excluded patients who denied informed consent, had previously been enrolled or underwent elective open-heart surgery during the hospitalisation leading to the ICU admission. 4,29…”

Section: Populationmentioning

confidence: 99%

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Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub‐study of the PLOT‐ICU cohort

Anthon,

Pène,

Perner

et al. 2023

Acta Anaesthesiol Scand

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IntroductionPlatelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia.MethodsThis is a protocol and statistical analysis plan for a post hoc sub‐study of 504 thrombocytopenic patients from the ‘Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT‐ICU)’. The primary outcome will be the number of patients receiving platelet transfusion in the ICU reported according to the type of product received (apheresis‐derived versus pooled whole‐blood‐derived transfusions). Secondary platelet transfusion outcomes will include platelet transfusion volumes; timing of platelet transfusion; approach to platelet transfusion dosing (fixed dosing versus weight‐based dosing) and platelet count increments for prophylactic transfusions. Secondary clinical outcomes will include the number of patients receiving red blood cell‐ and plasma transfusions during ICU stay; the number of patients who bled in the ICU, the number of patients who had a new thrombosis in the ICU, and the number of patients who died. The duration of follow‐up was 90 days. Baseline characteristics and secondary clinical outcomes will be stratified according to platelet transfusion status in the ICU and severity of thrombocytopenia. Data will be presented descriptively.ConclusionsThe outlined study will provide detailed epidemiological data on the use of platelet transfusions in adult ICU patients with thrombocytopenia using data from the large international PLOT‐ICU cohort study. The findings will inform the design of future randomised trials evaluating platelet transfusions in ICU patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…All necessary national/regional/local approvals were obtained as appropriate, and informed consent was sought from patients and/or relatives if required by applicable regulations. 4,29…”

Section: Ethics and Approvalsmentioning

confidence: 99%

Section: Populationmentioning

confidence: 99%

Section: Populationmentioning

confidence: 99%

See 3 more Smart Citations

Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub‐study of the PLOT‐ICU cohort

Anthon,

Pène,

Perner

et al. 2023

Acta Anaesthesiol Scand

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View full text Add to dashboard Cite

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Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)

Anthon,

Pène,

Perner

et al. 2023

Intensive Care Med

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Purpose: Thrombocytopenia (platelet count < 150 × 10 9 /L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. Methods:We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses. Results:We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission,

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Clinical significance of thrombocytopenia in patients with septic shock: An observational retrospective study

Péju

Fouqué

Charpentier

et al. 2023

Journal of Critical Care

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Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)

Cited by 10 publications

References 36 publications

Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub‐study of the PLOT‐ICU cohort

Platelet transfusions in adult thrombocytopenic ICU patients: Protocol for a sub‐study of the PLOT‐ICU cohort

Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)

Clinical significance of thrombocytopenia in patients with septic shock: An observational retrospective study

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