Platelet Transfusions From HL-A Compatible Unrelated Donors to Alloimmunized Patients

Lohrmann, Hans‐Peter

doi:10.7326/0003-4819-80-1-9

Cited by 123 publications

(40 citation statements)

References 21 publications

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“…HL-A lymphocyte-matched siblings as platelet donors have worked exceedingly well in their studies, and the use of unrelated HL-A-matched donors has been successful (5)(6)(7). These findings have been extended recently to patients with hematological malignancies with mean increases in platelet counts between 5,000 and 13,000/mm' X m' per unit of platelet transfused at 20 h after HL-Amatched platelet transfusion (8).…”

Section: Introductionmentioning

confidence: 65%

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Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching.

Gockerman¹,

Bowman²,

Conrad³

1975

J. Clin. Invest.

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A B S T R A C T The detection of platelet isoantibodies by the release of ['H]serotonin from platelets has been evaluated. The conditions for optimal release of ['H]serotonin with platelet isoantibodies using a microtechnique have been defined. A group of cardiac surgery patients were followed pre-and post-transfusions, with 48% developing a positive serotonin release assay. Of these patients, 16% also had a platelet complement-fixing and/or lymphocytotoxic isoantibody. There was variation in the degree of correlation between ['H]serotonin release and lymphocytotoxicity using individual National Institutes of Health typing serum. The matching obtained between family members by both techniques showed a close correlation when each technique was evaluated separately using the same NIH typing serum. The detection of isoantibodies in patients with hematological malignancies correlated with the unresponsiveness to unmatched platelet transfusions in 15 out of 17 cases. The use of the patient's isoantibody to matched platelets of family members by ['H]serotonin release correlated well with the clinical response to transfusion with these platelets. The data suggest that (a) platelet isoantibodies can be

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Section: Introductionmentioning

confidence: 65%

“…Platelet-specific antigens, which in certain clinical situations are of prime importance, are not detected by HL-A lymphocyte typing (12). Further, certain lymphocyte HL-A antigens may not be present on platelets and thus need not be matched (8).…”

Section: Introductionmentioning

confidence: 99%

Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching.

Gockerman¹,

Bowman²,

Conrad³

1975

J. Clin. Invest.

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“…There was evidence that PC from HLA-selected donors reduce refractoriness to platelets [40][41][42][43]. Therefore, in the USA the use of APC increased by 34% between 1987 and 1989 [44] and by 50% between 1989 and 1991.…”

Section: Trends and Prospectsmentioning

confidence: 99%

Platelet Concentrates from Automated Apheresis – Past, Present and Future Developments

Zeiler¹,

Kretschmer²

2000

Transfus Med Hemother

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The preparation of platelet concentrates by automated apheresis started in the early 1970s. Originally intended to increase the amount of platelets from selected (HLA compatible) donors to supply HLA-immunized patients, plateletpheresis has permanently expanded. Further development of plateletpheresis is described. Considering medical and economical perspectives, actual trends and possible future developments of plateletpheresis are discussed.

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“…Multiple transfusions of platelets from random donors, however, frequently result in development of resistance to infused platelets due to alloimmunization and subsequent refractoriness to further platelet support. [1][2][3] Recently, platelet pheresis with automated blood cell processors obtaining a large number of platelets collected from selected individuals with compatible platelet HLA antigens has become a routine procedure. 4 Most platelet pheresis donors in Saudi Arabia are either North Americans or Europeans whose HLA antigens are distinctly different from those of the Saudis.…”

Section: Platelet Pheresis and Hla-antigens In Saudi Arabiamentioning

confidence: 99%

Platelet Pheresis and HLA-Antigens in Saudi Arabia

Khalil

1988

Ann Saudi Med

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Platelet Transfusions From HL-A Compatible Unrelated Donors to Alloimmunized Patients

Cited by 123 publications

References 21 publications

Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching.

Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching.

Platelet Concentrates from Automated Apheresis – Past, Present and Future Developments

Platelet Pheresis and HLA-Antigens in Saudi Arabia

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