Platelet tritiated imipramine binding in patients suffering from mania

Ellis, Pete; Mellsop, Graham; R, Beeston; Cooke, R.

doi:10.1016/0165-0327(91)90043-r

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Platelet Studies1

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1999

2009

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Cited by 8 publications

(1 citation statement)

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“…The binding affinity of this site to imipramine in platelets has been examined to gain information about 5-HT neuron function in manic patients. Of the four studies that examined imipramine binding in manic patients, two showed an increase (55,56), while the other two showed no difference (57,58) in binding in manics compared to depressed patients. However, all four studies reported that binding was not different in manics when compared to healthy controls.…”

Section: Platelet Studiesmentioning

confidence: 96%

Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies

Shiah

Yatham

2000

Bipolar Disorders

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There is some evidence from clinical studies for the contribution of 5-HT in mania and in the mechanism of action of mood stabilizers. However, it is very likely that other neurotransmitters also play important roles. Future directions for research include 1) in vivo study of 5-HT receptor subtypes using positron emission tomography, 2) investigation of the interaction between 5-HT and other neurotransmitter systems, and 3) determination of the relationships between diagnostic subtypes of mania and 5-HT function and other neurotransmitter systems.

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