Plateletpheresis Experience with the Haemonetics Blood Processor 30, the IBM Blood Processor 2997, and the Fenwal CS-3000 Blood Processor

Abstract

Comparisons were made of the apheresis instruments Haemonetics Blood Processor 30, IBM Blood Processor 2997 and Fenwal CS-3000, for collection of platelets from normal donors. With each instrument the mean recovery was at least 4x10^11 platelets per procedure, and each instrument afforded a safe and reliable collection. The Haemonetics Blood Processor gave the lowest recovery of platelets per minute per procedure. The IBM Blood Processor 2997 required the longest time for set-up and priming and processed 1.5 liters more donor blood per collection than the other instruments. The Fenwal CS-3000, which is a computer-controlled instrument, was the least time consuming. The donor suffered a significantly greater drop in platelet count after collection with the IBM Blood Processor 2997 (31%) than after collection with the other instruments (19%), and we were unable to account for this observation.

Panel V: Cellular depletion by apheresis

“…The fall in platelet count that can be demonstrated immediately following mechanical cytapheresis is generally 20-30% below the preapheresis value [7,11,15]. A representative pre-and postcytapheresis value is 250 x 103/pl falling to 180 x 103/pl.…”

“…A decrease in the platelet count of donor blood varies with technique; it is influenced both by removal of platelets and by hemodilution. The fall in platelet count that can be demonstrated immediately following mechanical cytapheresis is generally 20-30% below the preapheresis value [7,11,15]. A representative pre-and postcytapheresis value is 250 x 103/pl falling to 180 x 103/pl.…”

Platelet Collection with the Autopheresis-C® Apheresis System

“…The white cell residuum in platelet con centrates prepared by centrifugally based systems is typical ly comprised mainly of lymphocytes [32], as seen here. The results of the battery of in vitro platelet function assays indicate that, in general, in vitro function is well maintained over the 5-day storage period.…”

Platelet Concentrates from Automated Apheresis – Past, Present and Future Developments

“…Thus, the donated blood could be separated into components directly at the donor, collecting the platelets and returning the residual blood components to the donor. This technique increased the amount of platelets obtained from a single donor during single apheresis up to 4 × 10 11 per PC obtained by automated apheresis (APC) [8,9]. The loss of RBC was minimized, and the frequency of platelet donations could be significantly increased.…”