Platelets

Westrick, Randal J.; Fredman, Gabrielle

doi:10.1161/atvbaha.115.305898

Cited by 8 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NIHSS has a maximum score of 42 and a minimum score of 0. The interpretations of NIHSS are: score> 25 is very heavy, 14–25 severe, 5–14 moderate, and <5 mild [ [11] , [21] ].…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of Platelet-to-White Blood Cell Ratio (PWR) and National Institute of Health Stroke Scale (NIHSS) in acute ischemic stroke

Amalia

Dalimonthe

2020

Heliyon

View full text Add to dashboard Cite

Introduction Ischemic stroke can occur due to disruption of blood and oxygen supply to brain tissue. White blood cells and platelets play an important role in the pathogenesis of ischemic stroke. Several studies have concluded that the lower the platelet count and the higher the number of white blood cells in ischemic stroke patients will result in a more severe stroke and had worsen prognosis. Platelet and white blood cells counts can be converted into Platelet-to-White Blood Cell Ratio (PWR) which is a comparison between the number of platelets and white blood cells, so the higher PWR will provide better clinical outcomes. Here, we examined correlation between PWR and clinical outcome in acute ischemic stroke using NIHSS tools. Method This research method was a retrospective analytic from 503 medical records of ischemic stroke patients from January 2015 to December 2017. Ischemic stroke divided into 2 groups: cardioembolic stroke and atherothrombotic stroke based on medical records. We calculated PWR and National Institute of Health Stroke Scale (NIHSS) for assessing clinical outcome. Statistical significance calculated with Spearman rank test, ANOVA, and multiple logistic regression. Results A total of 391 research subjects consisting of 213 females (54.5%) and 178 males (45.5%). The mean age of 57.14 years, and 82% subjects had hypertension as risk factor. Mean PWR of atherothrombotic stroke subjects were higher than cardioembolic stroke (33.02 vs 26.73) but had lower mean of NIHSS (5.81 vs 10.31) and had strong negative significant correlation between PWR and NIHSS (r = -0.9603; p < 0.001). From logistic regression, we found that PWR and platelet was statistically significance correlate with NIHSS (p < 0.05). The coefficient if PWR is the highest (absolute value) among other independent variables.It shows that PWR has positive effect on clinical outcome using NIHSS tools in acute ischemic stroke patients. Conclusion Cardioembolic stroke had higher PWR compared with atherothrombotic stroke. PWR had a strong correlation with NIHSS. The higher PWR will provide higher NIHSS and PWR has positive effect on clinical outcome using NIHSS tools in acute ischemic stroke patients.

show abstract

“…NIHSS has a maximum score of 42 and a minimum score of 0. The interpretations of NIHSS are: score> 25 is very heavy, 14–25 severe, 5–14 moderate, and <5 mild [ [11] , [21] ].…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of Platelet-to-White Blood Cell Ratio (PWR) and National Institute of Health Stroke Scale (NIHSS) in acute ischemic stroke

Amalia

Dalimonthe

2020

Heliyon

View full text Add to dashboard Cite

show abstract

“…Individual’s thrombogenic potential is determined not only by local factors like plaque morphology and stability, but also by systemic hemostatic factors comprising coagulation factors, fibrinolytic factors, and platelets 3 . Among these systemic factors, platelets are regarded to play a major role in driving atherothrombosis by localizing to lesions, delivering prothrombotic and proinflammatory molecules, and facilitating inflammatory cell infiltration into lesions 4 . Although different measures of various systemic factors have been shown to be predictive of cardiovascular events 5 , an in situ real-time monitoring system to be able to detect the local thrombus formation, especially at its early stage, as well as the traveling thrombus is critical for early warning of heart attack and stroke events.…”

Section: Introductionmentioning

confidence: 99%

High Sensitivity of T-Ray for Thrombus Sensing

Sun

Chen

Tseng

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Atherosclerotic plaque rupture or erosion and subsequent development of platelet-containing thrombus formation is the fundamental cause of cardiovascular disease, which is the most common cause of death and disability worldwide. Here we show the high sensitivity of 200–270 GHz T-ray to distinguish thrombus formation at its early stage from uncoagulated blood. A clinical observational study was conducted to longitudinally monitor the T-ray absorption constant of ex-vivo human blood during the thrombus formation from 29 subjects. Compared with the control group (28 subjects) with uncoagulated blood samples, our analysis indicates the high sensitivity of 200–270 GHz T-Ray to detect thrombus with a low p-value < 10−5. Further analysis supports the significant role of platelet-activated thrombotic cascade, which modified the solvation dynamics of blood and occurred during the early coagulation stage, on the measured T-Ray absorption change. The ability to sense the thrombus formation at its early stage would hold promise for timely identification of patients at risk of various atherothrombotic disorders and save billions of lives.

show abstract

Inflammation of the periodontium associates with risk of future cardiovascular events

Dyke

Kholy

Ishai

et al. 2021

Journal of Periodontology

View full text Add to dashboard Cite

Background: While growing evidence suggests a link between periodontal disease (PD) and cardiovascular disease (CVD), the independence of this association and the pathway remain unclear. Herein, we tested the hypotheses that: (1) inflammation of the periodontium (PD inflammation) predicts future CVD independently of disease risk factors shared between CVD and PD, and (2) the mechanism linking the two diseases involves heightened arterial inflammation. Methods: 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) imaging was performed in 304 individuals (median age 54 years; 42.4% male) largely for cancer screening; individuals without active cancer were included. PD inflammation and arterial inflammation were quantified using validated 18 F-FDG-PET/CT methods. Additionally, we evaluated the relationship between PD inflammation and subsequent major adverse cardiovascular events (MACE) using Cox models and log-rank tests. Results: Thirteen individuals developed MACE during follow-up (median 4.1 years). PD inflammation associated with arterial inflammation, remaining significant after adjusting for PD and CVD risk factors (standardized β [95% CI]: 0.30 [0.20-0.40], P < 0.001). PD inflammation predicted subsequent MACE (standardized HR [95% CI]: 2.25 [1.47 to 3.44], P <0.001, remaining significant in multivariable models), while periodontal bone loss did not. Furthermore, mediation analysis suggested that arterial inflammation accounts for 80% of the relationship between PD inflammation and MACE (standardized log odds ratio [95% CI]: 0.438 [0.019-0.880], P = 0.022). Conclusion: PD inflammation is independently associated with MACE via a mechanism that may involve increased arterial inflammation. These findings provide important support for an independent relationship between PD inflammation and CVD.

show abstract

Platelets

Cited by 8 publications

References 52 publications

Clinical significance of Platelet-to-White Blood Cell Ratio (PWR) and National Institute of Health Stroke Scale (NIHSS) in acute ischemic stroke

Clinical significance of Platelet-to-White Blood Cell Ratio (PWR) and National Institute of Health Stroke Scale (NIHSS) in acute ischemic stroke

High Sensitivity of T-Ray for Thrombus Sensing

Inflammation of the periodontium associates with risk of future cardiovascular events

Contact Info

Product

Resources

About