Platelets count and platelets indices; mean platelet volume and plateletcrit in pediatric chronic lung disease

Abstract

Background: The lungs contribute in the final maturation of the circulating platelets, and some studies suggested that chronic lung disease (CLD) could impair circulating platelets maturation or count. Our aim was to study the validity of platelet count (PLT), mean platelet volume (MPV), and plateletcrit (PCT) as simple tools to assess chronic lung disease severity or predict its course. Results: In 39 pediatric patients with CLD, we showed a significant rise in PLTs and PCT and a significant lower MPV when compared to normal controls (P values 0.003, 0.010, 0.004, respectively). Also, a significant positive correlation was detected between the C reactive protein (CRP) level and both the PLTs and PCT (r 0.327, 0.363 respectively) in addition to a significant reduction in MPV level in relation to the age of disease onset (P value 0.031). Conclusion: This study disagrees with the postulation that chronic lung disease could lead to the reduction of circulating platelets and emphasizes the role of increased platelets count and decreased MPV in reflecting the inflammatory condition underlying the chronic lung disease in the pediatric age group.

The Effects of Therapeutic Intermittent Hypoxia Implementation on Complete Blood Count Parameters: An Experimental Animal Model

“…Other studies, high levels of PCT were reported in pediatric cases with chronic lung disease, and the PCT value has been reported to show a positive correlation with C -reactive protein (CRP). In addition, in the pediatric mortality studies in the hospital, they were reported that the survival rate was higher in cases with high PCT values (21,22,23). According to our study, increased PCT (p=0.007) values can be interpreted as a reaction developed against hypoxia.…”

Association between thrombocytopenia and the severity of Covid-19 infection among hospitalized Egyptian patients

“…Moreover, Libby et al, indicated that the relationship between leukocyte count and increased platelet reactivity was observed in total leukocyte count, total neutrophil count, and total lymphocyte count [ 27 ]. Both neutrophil count and lymphocyte count showed a strong positive correlation with total leukocyte count (p < 0.05).The study by Draz et al, found no significant correlations between platelet count and hemoglobin level and So2 [ 34 ].…”

Prognostic Significance of Thrombocytopenia and Mean Platelet Volume in COPD Patients with Acute Exacerbations in ICU Settings

“…Platelet activation and increased coagulation in patients with COPD, along with oxidative stress, can exacerbate atherosclerosis [10]. This situation is also related to significantly increased platelet counts in patients with COPD [11]. In general, it has been shown that the platelet count in COPD patients is higher than in the general population [12].…”