Platelets in Inflammation and Immune Modulations: Functions Beyond Hemostasis

Huang, Hsuan-Shun; Chang, Hsin-Hou

doi:10.1007/s00005-012-0193-y

Cited by 42 publications

(36 citation statements)

References 108 publications

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“…3 Although not strictly appointed within the inflammatory pathway, the platelet can be viewed as an extension of the cellular immune system. [4][5][6][7][8] Recent evidence places the platelet in the middle of diverse inflammatory processes that influence normal leukocyte biology and inflammatory signals (Figure 1).…”

Section: Platelets and The Immune Systemmentioning

confidence: 99%

Platelets at the interface of thrombosis, inflammation, and cancer

Franco

Corken

Ware

2015

Blood

548

453

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Although once primarily recognized for its roles in hemostasis and thrombosis, the platelet has been increasingly recognized as a multipurpose cell. Indeed, circulating platelets have the ability to influence a wide range of seemingly unrelated pathophysiologic events. Here, we highlight some of the notable observations that link platelets to inflammation, reinforcing the platelet’s origin from a lower vertebrate cell type with both hemostatic and immunologic roles. In addition, we consider the relevance of platelets in cancer biology by focusing on the hallmarks of cancer and the ways platelets can influence multistep development of tumors. Beyond its traditional role in hemostasis and thrombosis, the platelet’s involvement in the interplay between hemostasis, thrombosis, inflammation, and cancer is likely complex, yet extremely important in each disease process. The existence of animal models of platelet dysfunction and currently used antiplatelet therapies provide a framework for understanding mechanistic insights into a wide range of pathophysiologic events. Thus, the basic scientist studying platelet function can think beyond the traditional hemostasis and thrombosis paradigms, while the practicing hematologist must appreciate platelet relevance in a wide range of disease processes.

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Section: Platelets and The Immune Systemmentioning

confidence: 99%

Platelets at the interface of thrombosis, inflammation, and cancer

Franco

Corken

Ware

2015

Blood

548

453

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“…A growing body of evidence from recent studies suggests that beyond hemostasis platelets play a key role in many inflammatory, allergic, and immune processes via interaction with endothelial cells [11][12][13]. Apart from platelet count, different platelet parameters such as mean platelet volume (MPV) and platelet distribution width (PDW) have also been investigated in an understanding that such parameters may influence the reactivity of platelets [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?

Olukman

Özdemir²,

Karadeniz³

et al. 2017

Blood Coagulation &Amp; Fibrinolysis

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Postnatal closure of the ductus arteriosus is a complicated two-phase process involving functional and structural changes. So far, the precise mechanisms regulating this process are not fully understood. A growing body of evidence from recent studies suggests that platelets play a key role in inflammatory processes including ductal closure via interaction with endothelial cells. The aim of this study is to assess whether a relationship exists between the occurrence and/or closure of hemodynamically significant ductus arteriosus (HSDA) and platelet parameters (platelet count, circulating platelet mass, mean platelet volume, platelet distribution width) in preterm newborns. This single-center, retrospective study included 824 premature infants between 24 and 34 gestational weeks, evaluated by echocardiography at postnatal 72-96 h. Infants with and without HSDA (n = 208 vs. n = 616) were compared in terms of platelet parameters recorded within the first 3 days of life. Oral or intravenous ibuprofen was commenced for medical treatment, and echocardiography was repeated 24 h thereafter to determine ductal closure. No statistically significant difference could be demonstrated between the groups in terms of baseline platelet parameters. HSDA was independently associated with early-onset neonatal sepsis. Thrombocytopenia, low circulating platelet mass, high platelet distribution width, or high mean platelet volume could not be demonstrated as a risk factor for HSDA. None of the platelet parameters had an influence on ductal closure after medical treatment. Unlike most reports in the literature, presence of HSDA was not associated with any platelet parameter in our study. We could not demonstrate an association between any platelet parameter and either persistence or closure after medical treatment.

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“…The platelet is equipped to influence inflammation and the innate immune response at several levels [2,5,6]. First, the platelet expresses a repertoire of pattern recognition receptors, toll-like receptors (TLRs), which initiate the innate immune response [7–11].…”

Section: Platelets and Inflammationmentioning

confidence: 99%

“…Neurodegenerative diseases [21], atherosclerosis [22–24], transfusion-related lung injury [25], rheumatoid arthritis [16], and SLE [16] represent just a sampling of the recent inflammation based pathways that have strong association with platelet activity [5]. …”

Section: Platelets and Inflammationmentioning

confidence: 99%

Platelet function beyond hemostasis and thrombosis

Ware

Corken²,

Khetpal³

2013

Current Opinion in Hematology

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Purpose of review The platelet paradigm that is well established in hemostasis and thrombosis can be extended to other disease states. A consideration for some major health issues, such as inflammation, cancer, infection, and neuroscience and how platelet function impacts the pathophysiology of each clinical situation is provided. Recent findings Decades of research and knowledge of platelet function exists and the same is true for inflammation and cancer. The literature is full of platelet biology overlapping into other, non-thrombotic, disease states. However, major gaps exist that prevent a complete mechanistic understanding of platelet function in these other diseases. While much of the overlap provides antidotal relationships, future studies will likely uncover novel pathophysiological pathways that are highly relevant to human diseases. Summary Recent findings in four major disease areas, inflammation, cancer, infection and neuroscience are described with current literature linking the disease to platelet function. The availability of anti-platelet therapies, such as aspirin, exist and future consideration can be given as to whether anti-platelet therapy is potentially beneficial or harmful as mechanisms of platelet involvement are better defined.

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Platelets in Inflammation and Immune Modulations: Functions Beyond Hemostasis

Cited by 42 publications

References 108 publications

Platelets at the interface of thrombosis, inflammation, and cancer

Platelets at the interface of thrombosis, inflammation, and cancer

Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?

Platelet function beyond hemostasis and thrombosis

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