Plateletten zengin plazma uygulamaları

Yılmaz, Bilge

doi:10.4274/tftr.78700

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…PRP is a centrifuged plasma component that contains multiple growth factors in a hyperphysiological ratio due to its high platelet concentration. PRP stimulates cell proliferation, mesenchymal cell chemotaxis and differentiation, angiogenesis, and total collagen production, and it also partially increases the expression of matrix metalloproteinases and endogenous growth factors [ 7 ]. PRP has been tried by different clinicians and the regeneration-enhancing effect of PRP in gynecological disorders has been demonstrated by various application methods, including intraovarian PRP injection [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of vitrification solution supplemented with platelet-rich plasma in rat ovarian tissue cryopreservation

GÖKHAN,

ÇAVUŞOĞLU,

KILIÇ

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim The subject of this study was to investigate the utility of platelet-rich plasma (PRP) in the cryopreservation process to reduce cryodamage and increase tissue viability. Materials and methods Twenty-one female Wistar rats were randomly allocated to three groups. In Group 1 (G1), rats were not subjected to vitrification (n = 7). Group 2 (G2) was the vitrification group in which PRP was added to the basic vitrification solution (n = 7). Group 3 (G3) was the vitrification group in which fetal bovine serum was added to the basic vitrification solution (n = 7). Warmed tissues were evaluated with histochemical (HC) and immunohistochemical (IHC) staining, the TUNEL method, immunofluorescence (IF) staining, and biochemical analyses. Results The percentages of IHC staining, TUNEL method positivity, and IF staining were significantly higher in G2 compared to both G1 and G3 (P < 0.05). G2 ovaries exhibited a significant increase in both malondialdehyde and catalase values in comparison to G1 (P < 0.05). In HC staining, degenerations in primary and secondary follicles and in ovarian tissue were more common in the PRP-supplemented group. The calcium used in PRP activation was suspected to have increased the degeneration and prevented the possible positive effects of PRP. Conclusion To the best of our knowledge, PRP-supplemented vitrification solution was used for the first time in the literature in this study in whole rat ovarian tissue vitrification. If PRP is to be used as a component in vitrification solution for rat ovarian tissue, the use of lower amounts of calcium or different methods in PRP activation, or the use of nonactivated PRP, should be considered from the beginning.

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Section: Introductionmentioning

confidence: 99%

Effects of vitrification solution supplemented with platelet-rich plasma in rat ovarian tissue cryopreservation

GÖKHAN,

ÇAVUŞOĞLU,

KILIÇ

et al. 2023

Turkish Journal of Medical Sciences

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“…[ 8 - 11 ] Similarly, for shoulder joints, numerous references are available regarding rotator cuff tendinopathy, bicipital tendinopathy, and the usage of PRP in superior labrum anterior-posterior lesions. [ 12 - 14 ]…”

Section: Introductionmentioning

confidence: 99%

Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: A prospective, randomized-controlled study

Karabaş¹,

Çalış²,

Topaloğlu³

et al. 2021

Turk J Phys Med Rehab

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Objectives: In this study, we aimed to investigate the effectiveness of intra-articular platelet-rich plasma (PRP) injection in adhesive capsulitis. Patients and methods: Between January 2019 and December 2019, a total of 40 patients (21 males, 19 females; mean age: 57.1±6.5 years; range, 44 to 72 years) with idiopathic adhesive capsulitis were included. The patients were randomly assigned into two equal groups as the PRP and the control group. The PRP group received two doses of PRP via intra-articular route biweekly under ultrasound guidance. No injection was performed to the control group. In both groups, stretching and Codman exercises were applied as a home- based program. The Visual Analog Scale (VAS), range of motion (ROM), and Shoulder Pain and Disability Index (SPADI) scores were evaluated before the treatment and at 2, 6 and 12 weeks after the treatment. Results: There were significant differences in all VAS, SPADI, and ROM scores at all time points after treatment compared to baseline in both groups. At the end of the study, there were significant differences in the active flexion, passive flexion, active abduction, passive abduction, and active external rotation scores at 12 weeks between the groups (p=0.012, p=0.015, p=0.008, p=0.019, and p=0.040, respectively). No significant difference was observed between the groups in terms of VAS and SPADI scores and the other parameters (active and passive extension, active and passive internal rotation, passive external rotation) at 2, 6, and 12 weeks (p>0.05). Conclusion: The addition of PRP to exercise treatment can improve patients' joint mobility, but not pain and disability in patients with adhesive capsulitis.

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Plateletten zengin plazma uygulamaları

Cited by 2 publications

References 11 publications

Effects of vitrification solution supplemented with platelet-rich plasma in rat ovarian tissue cryopreservation

Effects of vitrification solution supplemented with platelet-rich plasma in rat ovarian tissue cryopreservation

Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: A prospective, randomized-controlled study

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