Platinum and palladium complexes with 5-methyl-5-(2-pyridyl)-2,4-imidazolidenedione: Synthesis, crystal and molecular structure, theoretical study, and pharmacological investigation

Gold(iii) complexes of 5-methyl-5-(pyridyl)-2,4-imidazolidenedione: synthesis, physicochemical, theoretical, antibacterial, and cytotoxicity investigation

“…The low conductance value for complex 1 (11.70 O À1 cm 2 mol À1 ) suggested that the replacement of two chloride ligands by one L1 had occurred to give a neutral and non-electrolytic complex, 50 where L1 acts as a deprotonated N,N-bidentate ligand. 51 In complexes 2 and 3, the molar conductivity values, 79.12 and 43.45 O À1 cm 2 mol À1 , respectively, are in the range of 1 : 1 electrolytes in this solvent. 50 This may be taken as evidence for the presence of [AuCl 4 ] À as a counter-ion, indicating the electrolytic nature of these complexes.…”

“…By comparing the other chemical shifts of L1 and 1, we can conclude the NMR data supports the participation of both the hydantoin and pyridine rings in the coordination. 51 In the 1 H NMR spectra of 2 and 3, the signals of the protons from the pyridine ring are shifted to lower frequencies compared to the spectra of the ligands. There are noticeable differences between the proton chemical shifts of the ligands and the corresponding complexes.…”

“…2) has disappeared in 1, which shows the bidentate N-coordination of L1 to the metal center, realized through the nitrogen atom of the pyridine ring and the deprotonated nitrogen of the hydantoin ring. 51 On the other hand, in 2 and 3, as the nitrogen atom of the This change in the stretching frequency of these groups can be due to their proximity to the coordination site. Also, a solution IR study of the complexes in DMSO solvent supported the structures observed in the solid state, which also exist in solution.…”

Multivariant Crystallization of Tetraplatin Precursors from Solutions Containing 1,2-C6H10(NH3)2 2+ and [PtCl6]2– Ions

“…Today, the compound is one of the few platinum drugs, approved for clinical application [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Tetraplatin is similar to cisplatin on efficiency but has less nephrotoxicity [19].…”

Antiproliferative activity of platinum(II) complexes containing triphenylphosphine: Correlation between structure and biological activity

“…Moreover, a model compound containing PPh 3 and dimethylsulfoxide (DMSO) ligands was prepared (Chart 1, 2). As a matter of fact, given the coordinating character of DMSO, when phosphine complexes are dissolved in this solvent for the biological tests in vitro, substitution equilibria cannot be excluded a priori; small amounts of 2 could then form and affect the observed biological activity [10]. We report here the synthesis, the characterization and the X-ray structures of cis-[PtCl 2 (SOMe 2 )(PPh 3 )] (Chart 1, 2), and trans-[PtCl 2 (N-morpholino)(PPh 3 )] (Chart 1, 7) and, for all the available Pt complexes shown in the Chart 1, the in vitro antiproliferative activity towards HeLa, H460 and A549 human tumor cell lines.…”