Platinum based theranostics nanoplatforms for antitumor applications

Li, Heying; Cheng, Siyao; Zhai, Jingming; Lei, Kun; Zhou, Ping; Cai, Kaiyong; Li, Jinghua

doi:10.1039/d3tb01035j

Cited by 3 publications

(2 citation statements)

References 88 publications

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“…The t R value of an ionizable compound with basic functional groups in the LSER model can be expressed mathematically by the following equation (Eq. ): [23]

\vcenter{\openup.5em\halign{$\displaystyle{#}$\cr log{t}_{R}=log{t}_{{R}_{B}}+{{U}\over{1+V. {10}^{\pm (pH-{pK}_{a})}}}\ \hfill\cr}}

…”

Section: Resultsmentioning

confidence: 99%

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Comparison of Classical and Green RPLC Methods in the Determination of pK_a Values of Some Piperazine Group Antihistamines

Nane,

Çubuk Demiralay,

Daldal

2024

Chemistry A European J

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In this study, protonation constant values and liquid chromatographic behaviors of hydrophobic cyclizine, chlorcyclizine, hydroxyzine, cinnarizine, cetirizine, meclizine, and buclizine in some water‐organic solvent binary mixtures were examined for the first time using classical and green reverse phase liquid chromatography methods. In the isocratic study, the relationship of the retention time and mobile phase pH in water‐organic solvent binary mixtures containing acetonitrile (45, 50, 55, 60, 65, v/v), methanol (60, 65, 70, 75, v/v) and ethanol (45, 50, 55, 56, 59, 60, 62, 65, v/v) were determined at 37 °C. In the study, XBridge C18 and Gemini NX C18 columns suitable for the chemical properties of basic compounds were used. The obtained liquid chromatographic data were analyzed using the linear solvation energy relationship methodology and the SOLVER program. The aqueous protonation constant values of the investigated compounds were calculated using the linear relationship between the protonation constant data calculated in studied binary mixtures and some macroscopic constant values of the solvents used. The greenness of methods developed using three different solvents was evaluated with the Analytical Greenness Metric Approach, the Green Analytical Procedures Index, and the Green Solvent Selection Tool approaches.

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“…The t R value of an ionizable compound with basic functional groups in the LSER model can be expressed mathematically by the following equation (Eq. ): [23]

\vcenter{\openup.5em\halign{$\displaystyle{#}$\cr log{t}_{R}=log{t}_{{R}_{B}}+{{U}\over{1+V. {10}^{\pm (pH-{pK}_{a})}}}\ \hfill\cr}}

…”

Section: Resultsmentioning

confidence: 99%

“…where U and V are two fitting coefficients. The initial estimates for U and V were set at −1 and 4, respectively [23] . U from these coefficients is expressed with

{U={\rm l}{\rm o}{\rm g}\left(f\right)}

.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Classical and Green RPLC Methods in the Determination of pK_a Values of Some Piperazine Group Antihistamines

Nane,

Çubuk Demiralay,

Daldal

2024

Chemistry A European J

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Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects

Chen,

Shangguan,

Lin

et al. 2024

BMEMat

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X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical tumor treatment through radiotherapy. Despite their widespread use, optimizing X‐ray efficacy remains a critical challenge due to issues such as radiation resistance and damage to surrounding health tissues. Recent advancements in nanotechnology have introduced new opportunities and challenges in cancer diagnosis and treatment. This review summarizes the latest progress in nanomaterials for X‐ray‐triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. We examine how nanomaterials, including metals, metal oxides, metal sulfides, metal fluorides, rare earth oxides, cluster compounds, metal‐organic frameworks, and nanohybrids, enhance the effectiveness of X‐ray‐triggered treatments. Furthermore, we address the current challenges and future prospects of efficient X‐ray‐triggered cancer therapy, aiming to provide a comprehensive overview for researchers and clinicians in the field.

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Exploring the Impact of Head Group Modifications on the Anticancer Activities of Fatty-Acid-like Platinum(IV) Prodrugs: A Structure–Activity Relationship Study

Kshetri,

Jogadi,

Alqarni

et al. 2023

IJMS

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We conducted the first comprehensive investigation on the impact of head group modifications on the anticancer activities of fatty-acid-like Pt(IV) prodrugs (FALPs), which are a class of platinum-based metallodrugs that target mitochondria. We created a small library of FALPs (1–9) with diverse head group modifications. The outcomes of our study demonstrate that hydrophilic modifications exclusively enhance the potency of these metallodrugs, whereas hydrophobic modifications significantly decrease their cytotoxicity. To further understand this interesting structure–activity relationship, we chose two representative FALPs (compounds 2 and 7) as model compounds: one (2) with a hydrophilic polyethylene glycol (PEG) head group, and the other (7) with a hydrophobic hydrocarbon modification of the same molecular weight. Using these FALPs, we conducted a targeted investigation on the mechanism of action. Our study revealed that compound 2, with hydrophilic modifications, exhibited remarkable penetration into cancer cells and mitochondria, leading to subsequent mitochondrial and DNA damage, and effectively eradicating cancer cells. In contrast, compound 7, with hydrophobic modifications, displayed a significantly lower uptake and weaker cellular responses. The collective results present a different perspective, indicating that increased hydrophobicity may not necessarily enhance cellular uptake as is conventionally believed. These findings provide valuable new insights into the fundamental principles of developing metallodrugs.

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Platinum based theranostics nanoplatforms for antitumor applications

Abstract: Platinum (Pt) based nanoplatforms are biocompatible nanoagents with photothermal antitumor performance, while exhibiting excellent radiotherapy sensitization properties. The Pt-nanoplatforms hold a pivotal position in the realm of cancer treatment due...

Cited by 3 publications

References 88 publications

Comparison of Classical and Green RPLC Methods in the Determination of pK_a Values of Some Piperazine Group Antihistamines

Comparison of Classical and Green RPLC Methods in the Determination of pK_a Values of Some Piperazine Group Antihistamines

Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects

Exploring the Impact of Head Group Modifications on the Anticancer Activities of Fatty-Acid-like Platinum(IV) Prodrugs: A Structure–Activity Relationship Study

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Platinum based theranostics nanoplatforms for antitumor applications

Abstract: Platinum (Pt) based nanoplatforms are biocompatible nanoagents with photothermal antitumor performance, while exhibiting excellent radiotherapy sensitization properties. The Pt-nanoplatforms hold a pivotal position in the realm of cancer treatment due...

Cited by 3 publications

References 88 publications

Comparison of Classical and Green RPLC Methods in the Determination of pKa Values of Some Piperazine Group Antihistamines

Comparison of Classical and Green RPLC Methods in the Determination of pKa Values of Some Piperazine Group Antihistamines

Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects

Exploring the Impact of Head Group Modifications on the Anticancer Activities of Fatty-Acid-like Platinum(IV) Prodrugs: A Structure–Activity Relationship Study

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Product

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Comparison of Classical and Green RPLC Methods in the Determination of pK_a Values of Some Piperazine Group Antihistamines

Comparison of Classical and Green RPLC Methods in the Determination of pK_a Values of Some Piperazine Group Antihistamines