Platinum-binding peptides: understanding of selective binding and multifunctionality

Pramounmat, Nuttanit; Yan, Katherine; Wolf, Jadon; Renner, Julie N.

doi:10.1088/2399-7532/ac4a86

Cited by 3 publications

(6 citation statements)

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“…99 There is an opportunity in the active Janus particle community to utilize polypeptide specificity for biological targets, as well as utilize polypeptide affinity for solid materials including gold 100 and platinum. 101 For example, peptide-functionalized gold nanoparticles already serve as effective cell-targeting agents. 102 In addition, peptides bound to solid surfaces have been shown to influence catalytic reactivity in various ways, including via controlling surface coverage and stabilizing catalyst composition (Figure 3).…”

Section: Affinity Sequencesmentioning

confidence: 99%

“…105 Examples of controlling platinum reactivity via peptides have also been reported. 101 Affinity is assessed using techniques such as isothermal calorimetry, surface plasmon resonance, and quartz crystal microbalance with dissipation monitoring.…”

Section: Affinity Sequencesmentioning

confidence: 99%

“…Depending on the application, sequences that have already been discovered to have high affinity for a target can be utilized, iterated, or newly designed . There is an opportunity in the active Janus particle community to utilize polypeptide specificity for biological targets, as well as utilize polypeptide affinity for solid materials including gold and platinum . For example, peptide-functionalized gold nanoparticles already serve as effective cell-targeting agents .…”

Section: Designing Peptides and Polypeptidesmentioning

confidence: 99%

“… , In one illustrative example, a series of gold-binding peptides were used to make gold nanoparticles, and it was discovered that the aspects of the biotic/abiotic interface including the amount of exposed gold surface, the underling surface structural disorder, and the interaction strength of the peptide all influenced the catalytic activity of the materials for 4-nitrophenol reduction . Examples of controlling platinum reactivity via peptides have also been reported . Affinity is assessed using techniques such as isothermal calorimetry, surface plasmon resonance, and quartz crystal microbalance with dissipation monitoring.…”

Section: Designing Peptides and Polypeptidesmentioning

confidence: 99%

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Engineered Polypeptides as a Tool for Controlling Catalytic Active Janus Particles

Issa

Calderon

Kamlet

et al. 2023

ACS Appl. Eng. Mater.

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Active Janus colloids are functional particles that combine two distinct chemical or physical surface properties. The anisotropic nature of this class of patchy particles allows them to harvest and redirect energy to create a local force that leads to autonomous motion. Modulating the surface forces experienced by or the responsiveness of a Janus particle's surface offer an avenue of further control. There are broad efforts in the community to advance the fundamental understanding of and engineer such control into active systems. This article aims to summarize recent work in catalytic active Janus colloids, peptide and polypeptide engineering and design, and present work showing how engineered polypeptides can be used to control motion of catalytic active particles. Experiments probing nonspecific effects are reviewed that measured the active motion of 5 μm catalytic Janus spheres in the presence of low molecular weight polyethylene glycol (PEG). Previous work has found that at infinitely dilute concentrations of particles, the addition of PEG in solution reduced particle propulsion speed. Further increasing particle concentration led to increased clustering at low concentrations of PEG, but clustering was then reduced at high concentrations of PEG. These results inspired work presented herein with 3 μm particles that shows platinum binding peptides that specifically attach to the platinum cap reduced the propulsion speed. These data support a pathway for using engineered peptides as tools for controlling the activity of catalytic active Janus particles. Overall, this article highlights how nonspecific and specific molecular interactions can achieve control in active systems.

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Section: Affinity Sequencesmentioning

confidence: 99%

Section: Affinity Sequencesmentioning

confidence: 99%

Section: Designing Peptides and Polypeptidesmentioning

confidence: 99%

Section: Designing Peptides and Polypeptidesmentioning

confidence: 99%

See 2 more Smart Citations

Engineered Polypeptides as a Tool for Controlling Catalytic Active Janus Particles

Issa

Calderon

Kamlet

et al. 2023

ACS Appl. Eng. Mater.

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“…Technology which enables the use of peptides on polymer scaffolds would be useful for REE capture as well as: phosphate capture, 29 antimicrobial coatings, 31 copper and zinc capture, 32 and precious metal capture. 33 Current state-of-the-art technology for bio-inspired REE recovery focuses on column separations using whole lanmodulin protein 34 – while this strategy may be effective, peptides can potentially be attached at higher densities on a separation material due to their smaller size (∼1600 Da for peptide, ∼12 000 Da for lanmodulin 35 ). Our previous study demonstrated the ability of gold-bound peptide to capture REEs, 29 however a gold surface likely has limited applications.…”

Section: Introductionmentioning

confidence: 99%

Clickable polymer scaffolds enable Ce recovery with peptide ligands

et al. 2023

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Cobalt Oxide Nanoparticle Synthesis by Cell-Surface-Engineered Recombinant Escherichia coli and Potential Application for Anticancer Treatment

Kumaravel,

Sengupta,

Sathiyamoorthy

et al. 2024

ACS Omega

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Cell surface display engineering facilitated the development of a cobalt-binding hybrid Escherichia coli. OmpC served as the molecular anchor for showcasing the cobalt-binding peptides (CBPs), creating the structural model of the hybrid OmpC− CBPs (OmpC−CP, OmpC−CF). Subsequently, the recombinant peptide's cobalt adsorption and retrieval effectiveness were evaluated at various concentrations. When subjected to a pH of 7 and a concentration of 2 mM, OmpC−CF exhibited a significantly higher cobalt recovery rate (2183.87 mol/g DCW) than OmpC−CP. The strain with bioadsorbed cobalt underwent thermal treatment at varying temperatures (400 °C, 500 °C, 600 °C, and 700 °C) and morphological characterization of the thermally decomposed cobalt nanoparticle oxides using diverse spectroscopy techniques. The analysis showed that nanoparticles confined themselves to metal ions, and EDS mapping detected the presence of cobalt on the cell surface. Finally, the nanoparticles' anticancer potential was assessed by subjecting them to heating at 500 °C in a furnace; they demonstrated noteworthy cytotoxicity, as evidenced by IC 50 values of 59 μg/mL. These findings suggest that these nanoparticles hold promise as potential anticancer agents. Overall, this study successfully engineered a recombinant E. coli capable of efficiently binding to cobalt, producing nanoparticles with anticancer properties. The results of this investigation could have significant implications for advancing novel cancer therapies.

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Platinum-binding peptides: understanding of selective binding and multifunctionality

Cited by 3 publications

References 0 publications

Engineered Polypeptides as a Tool for Controlling Catalytic Active Janus Particles

Engineered Polypeptides as a Tool for Controlling Catalytic Active Janus Particles

Clickable polymer scaffolds enable Ce recovery with peptide ligands

Cobalt Oxide Nanoparticle Synthesis by Cell-Surface-Engineered Recombinant Escherichia coli and Potential Application for Anticancer Treatment

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