Platinum‐Coordinated Dual‐Responsive Nanogels for Universal Drug Delivery and Combination Cancer Therapy

Duan, Qiu‐Yi; Zhu, Ya‐Xuan; Jia, Hao‐Ran; Guo, Yuxin; Gu, Ruihan; Li, Chengcheng; Wu, Fu‐Gen

doi:10.1002/smll.202203260

Cited by 19 publications

(12 citation statements)

References 62 publications

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“…For example, Duan et al studied the loading of different FITC-labeled proteins into dual-responsive NGs to develop multifunctional carriers for combined cancer therapy. [137] These colloidal systems are based on 𝛽-CD-conjugated HA, polyethyleneimine (PEI), and cisplatin. In this case, cisplatin served two purposes: first, as small molecule drug and second, as coordinative crosslinker for electrostatic HA-PEI assemblies.…”

Section: Direct Determinationmentioning

confidence: 99%

Rational Design and Development of Polymeric Nanogels as Protein Carriers

López‐Iglesias

Klinger

2023

Macromolecular Bioscience

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Proteins have gained significant attention as potential therapeutic agents owing to their high specificity and reduced toxicity. Nevertheless, their clinical utility is hindered by inherent challenges associated with stability during storage and after in vivo administration. To overcome these limitations, polymeric nanogels (NGs) have emerged as promising carriers. These colloidal systems are capable of efficient encapsulation and stabilization of protein cargoes while improving their bioavailability and targeted delivery. The design of such delivery systems requires a comprehensive understanding of how the synthesis and formulation processes affect the final performance of the protein. This review highlights critical aspects involved in the development of NGs for protein delivery, with specific emphasis on loading strategies and evaluation techniques. For example, factors influencing loading efficiency and release kinetics are discussed, along with strategies to optimize protein encapsulation through protein‐carrier interactions to achieve the desired therapeutic outcomes. The discussion is based on recent literature examples and aims to provide valuable insights for researchers working towards the advancement of protein‐based therapeutics.This article is protected by copyright. All rights reserved

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Section: Direct Determinationmentioning

confidence: 99%

Rational Design and Development of Polymeric Nanogels as Protein Carriers

López‐Iglesias

Klinger

2023

Macromolecular Bioscience

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“…Furthermore, the lone pair electrons of nitrogen atoms in branched PEI can stabilize metal ions via coordination interaction. Therefore, branched PEI has a wide range of applications in gene transfection [ 34 , 35 , 36 ], drug delivery [ 37 , 38 ], and molecular imaging [ 25 , 39 ].…”

Section: Overview Of Peimentioning

confidence: 99%

Polyethyleneimine-Based Drug Delivery Systems for Cancer Theranostics

Zhao

Zhou

2022

JFB

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With the development of nanotechnology, various types of polymer-based drug delivery systems have been designed for biomedical applications. Polymer-based drug delivery systems with desirable biocompatibility can be efficiently delivered to tumor sites with passive or targeted effects and combined with other therapeutic and imaging agents for cancer theranostics. As an effective vehicle for drug and gene delivery, polyethyleneimine (PEI) has been extensively studied due to its rich surface amines and excellent water solubility. In this work, we summarize the surface modifications of PEI to enhance biocompatibility and functionalization. Additionally, the synthesis of PEI-based nanoparticles is discussed. We further review the applications of PEI-based drug delivery systems in cancer treatment, cancer imaging, and cancer theranostics. Finally, we thoroughly consider the outlook and challenges relating to PEI-based drug delivery systems.

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“…25,26 Moreover, drugloaded nanogels with responsive properties for cancer therapy have been widely studied. [27][28][29][30][31] With regard to drugs encapsulated in nanogels, it is possible to release the drugs from the nanogels in normal tissues or systemic circulation without any triggering factors. By contrast, drug-conjugated nanogels with responsive properties can overcome the leakage of drugs and prevent the metabolism and excretion of drugs from the nanogels.…”

Section: Introductionmentioning

confidence: 99%