Platinum Drugs

Boulikas, Teni; Pantos, Alexandros; Bellis, Evagelos; Christofis, Petros

doi:10.1002/9780470697047.ch5

Cited by 40 publications

(59 citation statements)

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“…Although highly effective in treating a variety of cancers, the cure with cisplatin is still limited by several side effects [3], and by inherited or acquired resistance phenomena [4], only partially amended by the employment of more recently discovered carboplatin and oxaliplatin [5]. These clinical drawbacks have stimulated an extensive search for other cytotoxic metal-based agents with improved pharmacological properties [6].…”

Section: Introductionmentioning

confidence: 99%

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands

Santini

Pellei

Papini

et al. 2011

Journal of Inorganic Biochemistry

103

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Section: Introductionmentioning

confidence: 99%

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands

Santini

Pellei

Papini

et al. 2011

Journal of Inorganic Biochemistry

103

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“…15 The DNA cross-linking ability of cisplatin and its analogs have been well documented. 15–18 In addition, a new class of anticancer drugs with multinuclear platinum molecules linked by flexible arms is capable of forming long range inter- or intrastand cross-links. 19–21 A few studies have demonstrated the ability of platinum compounds to cross-link DNA with proteins.…”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometry Evidence for Cisplatin As a Protein Cross-Linking Reagent

Zhao

Phillips

et al. 2011

Anal. Chem.

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Cisplatin is a potent anti-cancer drug, which functions by cross-linking adjacent DNA guanine residues. However within one day of injection, 65~98% of the platinum in the blood plasma is protein-bound. It is generally accepted that cisplatin binds to methionine and histidine residues, but what is often underappreciated is that platinum from cisplatin has a 2+ charge and can form up to four bonds. Thus, it has the potential to function as a cross-linker. In this report, the cross-linking ability of cisplatin is demonstrated by Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS) with the use of standard peptides, the 16.8 kDa protein calmodulin (CaM), but was unsuccessful for the 64 kDa protein hemoglobin. The high resolution and mass accuracy of FTICR MS along with the high degree of fragmentation of large peptides afforded by collisionally activated dissociation (CAD) and electron capture dissociation (ECD) are shown to be a valuable means of characterizing cross-linking sites. Cisplatin is different from current cross-linking reagents by targeting new functional groups, thioethers, and imidazoles groups, which provides complementarity with existing cross-linkers. In addition, platinum(II) inherently has two positive charges which enhance the detection of cross-linked products. Higher charge states not only promote the detection of cross-linking products with less purification, but result in more comprehensive MS/MS fragmentation and can assist the assignment of modification sites. Moreover, the unique isotopic pattern of platinum flags cross-linking products and modification sites by mass spectrometry.

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“…The focus in this area has shifted toward drug delivery, as in the case of lipoplatin, a liposomal derivative of cisplatin (see Chapter 13, Section 7.1). 98 Cisplatin analogs include tetragonal Pt(II) complexes, such as carboplatin, nedaplatin, oxaliplatin, ZD-0473, and SKI-2053R. Octahedral Pt(IV) complexes are also known, including tetraplatin, Structure of a cisplatin-induced DNA interstrand cross-link.…”

Section: Platinum Complexesmentioning

confidence: 99%

DNA Alkylating Agents

Avendaño

2015

Medicinal Chemistry of Anticancer Drugs

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Platinum Drugs

Cited by 40 publications

References 0 publications

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands

Mass Spectrometry Evidence for Cisplatin As a Protein Cross-Linking Reagent

DNA Alkylating Agents

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