Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy

Depciuch, Joanna; Stec, Małgorzata; Klębowski, Bartosz; Baran, Jarosław; Parlinska-Wojtan, Magdalena

doi:10.1186/s12951-019-0539-2

Cited by 23 publications

(7 citation statements)

References 52 publications

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“…Up to the present time, there are no Gd 3+ -bearing AuNPs that have been evaluated in clinical trials for MRI, and PET/MRI bimodal imaging studies are in general scarce [36][37][38][39]. While some studies have been done regarding the application of AuNPs for theranostics, their therapeutic function is mostly based on the photothermal properties of the AuNPs themselves or on the delivery of a payload acting as a cytotoxic drug [40][41][42][43][44][45][46]. There are some examples of AuNPs that have been evaluated in the delivery of medically relevant radionuclides, aiming to obtain "radiotheranostic" agents suitable to provide clear and sensitive tumor detection and selective therapeutic effects [47,48].…”

Section: Introductionmentioning

confidence: 99%

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

et al. 2020

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Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNPs carry a bombesin analogue with affinity towards the gastrin releasing peptide receptor (GRPr), overexpressed in a variety of human cancer cells, namely PC3 prostate cancer cells. The potential of these multimodal imaging nanoconstructs was thoroughly investigated by the assessment of their magnetic properties, in vitro cellular uptake, biodistribution, and radiosensitisation assays. The relaxometric properties predict a potential T1- and T2- MRI application. The promising in vitro cellular uptake of 67Ga/Gd-based bombesin containing particles was confirmed through biodistribution studies in tumor bearing mice, indicating their integrity and ability to target the GRPr. Radiosensitization studies revealed the therapeutic potential of the nanoparticles. Moreover, the DOTA chelating unit moiety versatility gives a high theranostic potential through the coordination of other therapeutically interesting radiometals. Altogether, our nanoparticles are interesting nanomaterial for theranostic application and as bimodal T1- and T2- MRI / SPECT imaging probes.

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Section: Introductionmentioning

confidence: 99%

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

et al. 2020

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“…Interest in bimetallic NPs as anti-cancer applications has increased due to their value in enhancing drug delivery strategies and NP-mediated hyperthermia treatments [ 319 ]. A number of studies reported that bimetallic gold-platinum NPs (AuPtNPs) of different sizes and shapes exhibit better photothermal effects and higher radiation-enhancing properties than the respective monometallic NPs (AuNPs and PtNPs), possibly due to the synergistic effects of the two composite metallic atoms and new surface properties that are different in their monometallic NPs [ 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 ]. Graphene quantum dots (GQDs) are considered promising nanomaterials for the PTT of cancer due to their biocompatibility, capability of crossing biological barriers, and rapid excretion as a result of their small size [ 328 , 329 ].…”

Section: Prospective Applications Of Ctx-np Formulationsmentioning

confidence: 99%

Diagnostic and Therapeutic Approaches for Glioblastoma and Neuroblastoma Cancers Using Chlorotoxin Nanoparticles

Boltman

Meyer

Ekpo

2023

Cancers

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Glioblastoma multiforme (GB) and high-risk neuroblastoma (NB) are known to have poor therapeutic outcomes. As for most cancers, chemotherapy and radiotherapy are the current mainstay treatments for GB and NB. However, the known limitations of systemic toxicity, drug resistance, poor targeted delivery, and inability to access the blood-brain barrier (BBB), make these treatments less satisfactory. Other treatment options have been investigated in many studies in the literature, especially nutraceutical and naturopathic products, most of which have also been reported to be poorly effective against these cancer types. This necessitates the development of treatment strategies with the potential to cross the BBB and specifically target cancer cells. Compounds that target the endopeptidase, matrix metalloproteinase 2 (MMP-2), have been reported to offer therapeutic insights for GB and NB since MMP-2 is known to be over-expressed in these cancers and plays significant roles in such physiological processes as angiogenesis, metastasis, and cellular invasion. Chlorotoxin (CTX) is a promising 36-amino acid peptide isolated from the venom of the deathstalker scorpion, Leiurus quinquestriatus, demonstrating high selectivity and binding affinity to a broad-spectrum of cancers, especially GB and NB through specific molecular targets, including MMP-2. The favorable characteristics of nanoparticles (NPs) such as their small sizes, large surface area for active targeting, BBB permeability, etc. make CTX-functionalized NPs (CTX-NPs) promising diagnostic and therapeutic applications for addressing the many challenges associated with these cancers. CTX-NPs may function by improving diffusion through the BBB, enabling increased localization of chemotherapeutic and genotherapeutic drugs to diseased cells specifically, enhancing imaging modalities such as magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), optical imaging techniques, image-guided surgery, as well as improving the sensitization of radio-resistant cells to radiotherapy treatment. This review discusses the characteristics of GB and NB cancers, related treatment challenges as well as the potential of CTX and its functionalized NP formulations as targeting systems for diagnostic, therapeutic, and theranostic purposes. It also provides insights into the potential mechanisms through which CTX crosses the BBB to bind cancer cells and provides suggestions for the development and application of novel CTX-based formulations for the diagnosis and treatment of GB and NB in the future.

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“…When these embedded NPs are exogenously irradiated with laser light, synchronized oscillation of the conduction-band electrons occurs, which generates heat. Increased temperature in the tumor causes cellular damage, such as protein denaturation, DNA repair deformities, changes in the permeability of the cell membrane, and subsequent tumor regression without damaging the surrounding healthy tissue. − …”

Section: Introductionmentioning

confidence: 99%

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Patel

Rathnayake

Singh

et al. 2023

ACS Appl. Bio Mater.

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The delivery and accumulation of therapeutic drugs into cancer cells without affecting healthy cells are a major challenge for antitumor therapy. Here, we report the synthesis of a liposomal hybrid gold nano-assembly with enhanced photothermal activity for lung cancer treatment. The core components of the nano-assembly include gold nanorods coated with a mesoporous silica shell that offers an excellent drug-loading surface for encapsulation of doxorubicin. To enhance the photothermal capacity of nano-assembly, IR 780 dye was loaded inside a thermo-sensitive liposome, and then, the core nano-assembly was wrapped within the liposome, and GE-11 peptide and folic acid were conjugated onto the surface of the liposome to give the final nano-assembly [(GM@Dox) LI]-PF. The dual targeting approach of [(GM@Dox) LI]-PF leads to enhanced cellular uptake and improves the accumulation of nano-assemblies in cancer cells that overexpress the epidermal growth factor receptor and folate. The exposure of near-infrared laser irradiation can trigger photothermal-induced structural disruption of the nano-assembly, which allows for the precise and controllable release of Dox at targeted sites. Additionally, chemo-photothermal therapy was shown to be 11 times more effective in cancer cell treatment when compared to Dox alone. Our systematic study suggests that the nano-assemblies facilitate the cancer cells undergoing apoptosis via an intrinsic mitochondrial pathway that can be directly triggered by the chemo-photothermal treatment. This study offers an appealing candidate that holds great promise for synergistic cancer treatment.

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Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy

Cited by 23 publications

References 52 publications

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

Diagnostic and Therapeutic Approaches for Glioblastoma and Neuroblastoma Cancers Using Chlorotoxin Nanoparticles

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

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