Platinum(II) Alkynyl Complexes Containing N‐ and S‐Propargylated Ligands: Synthesis, Structures and Formation of Pt^II/Ag^I Coordination Compounds

Abstract

Alkylation of 2-hydroxypyridine, 2-pyridinethiol, 2-hydroxy-4-methylquinoline, phthalimide and pyrazole with propargyl bromide gave a series of alkynes in high yield. These alkynes were reacted with the chloroplatinum(II) compounds trans-[PtCl 2 (PPh 3 ) 2 ] and cis-[PtCl 2 (dppe)] to afford the respective trans-and cis-bis(alkynyl)platinum(II) complexes, which were characterised by spectroscopic analysis and by X-ray

In vitro and in vivo evaluation of organometallic gold(i) derivatives as anticancer agents

“…The preparation of the alkyne ligands (RCH 2 C≡CH) (R = Spyridine, 1; Spyrimidine, 2; S(Me)pyrimidine, 3; S(Me) 2 pyrimidine, 4) was performed by the reaction of propargyl bromide with the corresponding thiol, in the presence of a base in acetone, as previously described in the case of 2-thiolpyridine (1) 61 All the complexes display low water-solubility with values below 5 mg/mL at room temperature, except compound 5, with a water solubility of 82 mg/mL. Nevertheless, they are regularly distributed between water and n-octanol, as deduced by the values observed in their corresponding partition coefficients (log D 7.4 ) next to 0 (Table 1).…”

“Click-and-click” – hybridised 1,2,3-triazoles supported Cu(i) coordination polymers for azide–alkyne cycloaddition

“…2-(2-Propynylthio)pyridine was synthesized according to the literature procedure. 11 The catalytic reactions were conducted by MultiMAX reactors. 1 H and 13 C NMR spectra were measured at r.t. with Bruker AMX 500 MHz FT NMR spectrometers.…”

“…Calcd for C 14 H 13 N 5 S (283.35): C,59.34;H,4.62;N,24.72;S,11.32. Found: C,59.87;H,4.43;N,24.70;S,11…”

“…Calcd for C 14 H 13 N 5 S (283.35): C,59.34;H,4.62;N,24.72;S,11.32. Found: C,59.11;H,4.55;N,24.52;S,11.20%. 1 H NMR (500 MHz, CDCl 3 ) for C 14 H 13 N 5 S (283.35): δ (ppm) = 8.55-8.54 (d,2H,1H,1H,7.48 (s,1H,1H, 2-Py-H), 7.01-7.00 (d, 2H, 4-Py-H), 6.95-6.98 (t, 1H, 2-Py-H), 5.46 (s, 2H, N-CH 2 ), 4.49 (s, 2H, S-CH 2 ).…”

Alternative reaction medium for the synthesis of 1-propargylpyrazoles

“…The methods of obtaining of 1-propargylpyrazoles under phase transfer catalysis [2,3], as well as by catalysis with potassium carbonate [4] are known.…”