Platinum(II) dithiocarbamate complexes [Pt(S2CNR2)Cl(PAr3)] as anticancer and DNA-damaging agents

Amir, Muhammad Kashif; Hogarth, Graeme; Khan, Zaibunisa; Imran, Muhammad; Rehman, Zia ur

doi:10.1016/j.ica.2020.119853

Cited by 6 publications

(2 citation statements)

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“…Researchers have synthesized monofunctional platinum(II)-based complexes and evaluated their biological activity. Such complexes form covalent adducts with the DNA structure, and undergo aquation inside the cell, causing displacement of a chloride ion ligand by a water molecule ligand; this enables union with nitrogenous bases, specifically the nitrogen 7 of guanine [ 22 , 48 , 49 , 50 , 51 ]. In other studies, complexes have been identified which act as intercalating agents because they have the capacity to be introduced between nitrogenous bases of DNA.…”

Section: Recent Studies On Platinum(ii) and Copper(ii) Complexes And ...mentioning

confidence: 99%

“…The following supporting information can be downloaded at: , Table S1: List of Pt(II) and Cu(II) complexes found and their molecular structure. References [ 14 , 15 , 16 , 17 , 18 , 20 , 21 , 22 , 23 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ] are cited in the Supplementary Materials .…”

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Recently Reported Biological Activities and Action Targets of Pt(II)- and Cu(II)-Based Complexes

Maciel-Flores,

Lozano-Alvarez,

Bivián-Castro

2024

Molecules

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Most diseases that affect human beings across the world are now treated with drugs of organic origin. However, some of these are associated with side effects, toxicity, and resistance phenomena. For the treatment of many illnesses, the development of new molecules with pharmacological potential is now an urgent matter. The biological activities of metal complexes have been reported to have antitumor, antimicrobial, anti-inflammatory, anti-infective and antiparasitic effects, amongst others. Metal complexes are effective because they possess unique properties. For example, the complex entity possesses the effective biological activity, then the formation of coordination bonds between the metal ions and ligands is controlled, metal ions provide it with extraordinary mechanisms of action because of characteristics such as d-orbitals, oxidation states, and specific orientations; metal complexes also exhibit good stability and good physicochemical properties such as water solubility. Platinum is a transition metal widely used in the design of drugs with antineoplastic activities; however, platinum is associated with side effects which have made it necessary to search for, and design, novel complexes based on other metals. Copper is a biometal which is found in living systems; it is now used in the design of metal complexes with biological activities that have demonstrated antitumoral, antimicrobial and anti-inflammatory effects, amongst others. In this review, we consider the open horizons of Cu(II)- and Pt(II)-based complexes, new trends in their design, their synthesis, their biological activities and their targets of action.

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Section: Recent Studies On Platinum(ii) and Copper(ii) Complexes And ...mentioning

confidence: 99%

mentioning

confidence: 99%

Recently Reported Biological Activities and Action Targets of Pt(II)- and Cu(II)-Based Complexes

Maciel-Flores,

Lozano-Alvarez,

Bivián-Castro

2024

Molecules

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Advances in anticancer applications of platinum(II) complexes of dithiocarbamates

Ahmad

2024

Med Chem Res

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Exploring the syntheses, crystal structures and photophysical properties of new anthracene-tethered Ni(II) dithiocarbamates

Dat

Lau²,

Hoang³

et al. 2022

Inorganica Chimica Acta

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Platinum(II) dithiocarbamate complexes [Pt(S2CNR2)Cl(PAr3)] as anticancer and DNA-damaging agents

Cited by 6 publications

References 40 publications

Recently Reported Biological Activities and Action Targets of Pt(II)- and Cu(II)-Based Complexes

Recently Reported Biological Activities and Action Targets of Pt(II)- and Cu(II)-Based Complexes

Advances in anticancer applications of platinum(II) complexes of dithiocarbamates

Exploring the syntheses, crystal structures and photophysical properties of new anthracene-tethered Ni(II) dithiocarbamates

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