Platinum(II) Drug-Loaded Gold Nanoshells for Chemo-Photothermal Therapy in Colorectal Cancer

Abstract

In the present study, we utilize a poly­[2-(N,N-dimethylamino)­ethyl methacrylate]-poly­(ε-caprolactone) (PDMA-PCL) micellar template-based gold nanoshell as a nanocarrier of a platinum-based chemotherapeutic drug, dichloro­(1,2-diaminocyclohexane)­platinum­(II) (DACHPt). The gold nanoshells not only function as a drug delivery platform but also provide a remarkable photothermal effect, resulting in synergistically combined chemo-photothermal therapy. With the positively charged outstretched hydrophilic PDMA segments, chloroauric anions are attracted to the PDMA-PCL micellar surface and reduced to gold atoms in situ, forming small seeds that nucleate the subsequent growth of gold nanoshells. The DACHPt-loaded gold nanoshells possess strong absorption in the near-infrared (NIR) region and outstanding photothermal conversion effect; thus, they can promote a temperature increase that is sufficient to ablate tumor cells under NIR laser irradiation at a moderate power density (1 W/cm2). Furthermore, by exploiting the synergistic effects of platinum-based chemotherapy and photothermal therapy, the DACHPt-loaded gold nanoshells exhibited a profound inhibition of tumor growth compared to chemotherapy or photothermal therapy alone. Therefore, the platinum­(II)-loaded gold nanoshells that we proposed herein may be a potential alternative for efficient curative therapy for colorectal cancer.

Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer

“…Moreover, GNSs, intended to produce a dramatic photothermal effect as well as inhibit premature drug release, were grown around the micellar surface, thus forming a highly biocompatible nanomedicine for chemo‐photothermal therapy of colorectal cancer. [ 47 ]…”

Nanomaterials and their composite scaffolds for photothermal therapy and tissue engineering applications

“…Noble metal-based nanomaterials are one of the most explored nanomaterials for PTT [57][58][59], and are prepared from Au, Ag, Pt, and Pd [60,61]. The PTT of noble-metal nanomaterials is based on their optical property of localized surface plasmon resonance (LSPR), which is a collective oscillation of lightinduced free electrons.…”

Nanomaterial‐mediated platinum drug‐based combinatorial cancer therapy

“…Subsequently, oligonucleotide‐modified GNRs, 60 polypeptide‐wrapped GNRs, 61 triangular and multicore Au@polymer nanoparticles, 62 tripeptide‐tethered hollow gold nanoparticles, 63 and gold nanoshells 64 are also reported to deliver platinum drugs to achieve combinatorial therapy. A multifunctional chemothermal therapy is reported by Zhang and coauthors 65 .…”