Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents

Vieites, Marisol; Otero, Lucı́a; Santos, Diego P. dos; Toloza, Jeannette; Figueroa, Roberto; Norambuena, Ester; Olea‐Azar, Claudio; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Morello, Antonio; Maya, Juan Diego; Garat, Beatríz; Gambino, Dinorah

doi:10.1016/j.jinorgbio.2007.12.005

Cited by 78 publications

(73 citation statements)

References 41 publications

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“…Only the Mexican strain H1 was resistant to both drugs, according to the criteria established in previous studies, because it had IC 50 G and IC 50 M values higher than 50 lM (Nirdé et al 1995, Villarreal et al 2005. The IC 50 M and IC 50 G values for the other Mexican strains were heterogeneous, and they were comparable with values reported for South American strains, such as Tulahuen 2 (TcIV), Dm28c (TcI), Silvio (TcI), Esmeraldo (TcII), and Y (TcII) (Cinque et al 1998, Vieites et al 2008, Wilkinson et al 2008, Luna et al 2009.…”

Section: Discussionsupporting

confidence: 60%

Microsatellite and Mini-Exon Analysis of Mexican Human DTU ITrypanosoma cruziStrains and Their Susceptibility to Nifurtimox and Benznidazole

Martı́nez

Nogueda

Martínez‐Hernández

et al. 2013

Vector-Borne and Zoonotic Diseases

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Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and it affects as many as 10 million people in North and South America, where it represents a major public health problem. T. cruzi is a parasite with high genetic diversity, and it has been grouped into 6 discrete typing units (DTUs), designated as T. cruzi I (TcI) to T. cruzi VI (TcVI). Mexican isolates from humans and from vector insects have been primarily found to be TcI, and these isolates are likely to be the strains that cause the clinical manifestations observed in Mexico. However, genetic characterization and drug susceptibility assays are limited in Mexican TcI strains. In this work, 24 Mexican T. cruzi strains, obtained primarily from humans, were studied with 7 locus microsatellites and mini-exon gene by PCR. Also, drug susceptibility was evaluated by growth and mobility assays. All of the human strains belonged to TcI, and they could be further grouped through microsatellite analysis into 2 subgroups (microsatellite genotypes 1 and 2), which were not related to the host clinical status or biological origin of the strain. Two strains, both from wild mammals, belonged to the TcII-TcVI groups; these strains and the CL Brener strain constituted microsatellite genotype 3. The number of alleles in each locus was lower than reported for South American strains, and a departure from the Hardy-Weinberg equilibrium was observed. The susceptibility of these strains to nifurtimox and benznidazole was heterogeneous. T. cruzi strains characterized as microsatellite genotypes 2 and 3 were significantly more susceptible to benznidazole than strains of microsatellite genotype 1. Only 1 Mexican strain resistant to both drugs was found in this study.

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Section: Discussionsupporting

confidence: 60%

Microsatellite and Mini-Exon Analysis of Mexican Human DTU ITrypanosoma cruziStrains and Their Susceptibility to Nifurtimox and Benznidazole

Martı́nez

Nogueda

Martínez‐Hernández

et al. 2013

Vector-Borne and Zoonotic Diseases

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“…It was measured through the MTT assay [23] using 0.22 mg mL phenazine metosulfate (as electron carrier). T. cruzi epimastigotes Dm28c strain, from our own collection (Programa de Farmacología Molecular y Clínica, Facultad de Medicina, Universidad de Chile) were grown at 28ºC in Diamond's monophasic medium, as reported earlier but replacing blood by 4 µM hemin [24]. Fetal calf serum was added to a final concentration of 5 %.…”

Section: Biological Assaysmentioning

confidence: 99%

Synthesis and Trypanocidal Properties of New Coumarin-Chalcone Derivatives

Rodríguez¹

2015

Med chem

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“…Many heterocyclic thiosemicarbazone derivatives and their platinum and palladium complexes have a wide range of pharmacological activities, such as antituberculosis [28], antibacterial [29], antitumor [30], antiprotozoal [31], antimalarial [32], antimicrobial [33], antiviral [34], antifungal [35], anticonvulsant [36] and anti-trypanosomal [37] activities. In our present work, the synthesis and characterization of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their platinum(II) and palladium(II) complexes are reported.…”

Section: Introductionmentioning

confidence: 99%

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

Karaküçük‐İyidoğan

Tasdemir

Oruç‐Emre

et al. 2011

European Journal of Medicinal Chemistry

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a b s t r a c tA series of thiosemicarbazones and their platinum(II) and palladium(II) complexes have been synthesized. The chemical structures of ligands and their complexes were characterized by UVeVis, IR, 1 H NMR, 13 C NMR, MS spectra, elemental analysis and TGA. The antiviral and cytotoxic activities of all compounds have been tested. Results of broad antiviral evaluation showed that none of the compounds evaluated endowed with anti-DNA or -RNA virus activity at subtoxic concentrations except for the palladium complex 1b. This compound exhibited slightly selective inhibition against cytomegalovirus. The platinum complex 4a exhibited the best cytostatic activities against human cervix carcinoma. Ligands 2, 4 and 5 showed cytostatic potential. The palladium complexes were in general less cytostatic than the corresponding platinum complexes or unliganded congeners.

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Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents

Cited by 78 publications

References 41 publications

Microsatellite and Mini-Exon Analysis of Mexican Human DTU ITrypanosoma cruziStrains and Their Susceptibility to Nifurtimox and Benznidazole

Microsatellite and Mini-Exon Analysis of Mexican Human DTU ITrypanosoma cruziStrains and Their Susceptibility to Nifurtimox and Benznidazole

Synthesis and Trypanocidal Properties of New Coumarin-Chalcone Derivatives

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

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