Platinum Nanoparticles: The Potential Antioxidant in the Human Lung Cancer Cells

Ismail, Noor Akmal Shareela; Lee, Jun Xin; Yusof, Fatimah

doi:10.3390/antiox11050986

Cited by 19 publications

(11 citation statements)

References 56 publications

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“…Ismail et al analyzed the potential of platinum nanoparticles to decrease oxidative stress conditions in lung cancer. The data supported that epithelial lung cancer cells did not survive when they were exposed to platinum nanoparticles for 3 h [ 131 ]. Cerium oxide nanoparticles also possess anticancer properties by inducing antioxidant activity.…”

Section: Applicationssupporting

confidence: 56%

Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications

Thao,

Do,

Nam

et al. 2023

Micromachines

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Antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase play important roles in the inhibition of oxidative-damage-related pathological diseases. However, natural antioxidant enzymes face some limitations, including low stability, high cost, and less flexibility. Recently, antioxidant nanozymes have emerged as promising materials to replace natural antioxidant enzymes for their stability, cost savings, and flexible design. The present review firstly discusses the mechanisms of antioxidant nanozymes, focusing on catalase-, superoxide dismutase-, and glutathione peroxidase-like activities. Then, we summarize the main strategies for the manipulation of antioxidant nanozymes based on their size, morphology, composition, surface modification, and modification with a metal-organic framework. Furthermore, the applications of antioxidant nanozymes in medicine and healthcare are also discussed as potential biological applications. In brief, this review provides useful information for the further development of antioxidant nanozymes, offering opportunities to improve current limitations and expand the application of antioxidant nanozymes.

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Section: Applicationssupporting

confidence: 56%

Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications

Thao,

Do,

Nam

et al. 2023

Micromachines

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“…Catalase activity according to their results was also reduced, but our research suggested increased catalase activity with time and concentration of NPs in cancer cell lines. Another study [56] examined the effect of Pt NPs on A549 cells and determined the elevation of SOD, GPx, as well as catalase activities. Their results indicate that Pt NPs might be a promising agent in the treatment of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Potential Health Risk of Gold Nanoparticles Used in Nanomedicine

Dvořáková

Kuračka

Žitňanová

et al. 2022

Oxidative Medicine and Cellular Longevity

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Due to unique properties, nanoparticles (NPs) have become a preferred material in biomedicine. The benefits of their use are indisputable, but their safety and potential toxicity are becoming more and more important. Especially, excessive production of reactive oxygen species (ROS) induced by the strong oxidation potential of metal NPs could evoke adverse effects associated with damage to nucleic acids, proteins and lipids. Our study gives a view on the potential cytotoxicity of gold NPs (Au NPs) of different size from the perspective of the redox state of healthy (HEK 293 T) and cancer (A375 and A594) cell lines. These cells were incubated in the presence of two concentrations of Au NPs for 24 h or 72 h and total antioxidant capacity, 8-isoprostane, and protein carbonyl levels were determined. Furthermore, the activity of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and catalase was detected in cell lysates. Our results compared to the results of other laboratories are very contradictory. The outcomes also differ between healthy and cancer cell lines. However, there are certainly changes in the activities of antioxidant enzymes, as well as the damage to biological molecules due to increased NP-induced oxidative stress. But the final decision of the effect of Au NPs on the oxidative state of selected cell lines requires further research.

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“…In addition, platinum NPs are used as drug delivery and imaging agents [ 296 , 297 , 298 , 299 ]. In vitro, analysis of platinum NPs inhibits the growth of A549 cancer cells in a dose-dependent manner [ 300 ]. Again, blood-triggered platinum NP sactas an anticancer agent by forming the protein corona [ 301 ].…”

Section: Novel Nanocarriers Based Treatment Approachmentioning

confidence: 99%

“…Again, blood-triggered platinum NP sactas an anticancer agent by forming the protein corona [ 301 ]. Another study revealed that platinum NPs reverse the oxidative stress in lung adenocarcinomas in the A549 lung cell line [ 299 , 300 ]. Again, biofabricated platinum NPs are biocompatible and have catalytic and anticancer activity [ 167 , 300 ].…”

Section: Novel Nanocarriers Based Treatment Approachmentioning

confidence: 99%

Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer

Sarma,

Akther,

Ahmad

et al. 2024

Molecules

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Lung cancer has the lowest survival rate due to its late-stage diagnosis, poor prognosis, and intra-tumoral heterogeneity. These factors decrease the effectiveness of treatment. They release chemokines and cytokines from the tumor microenvironment (TME). To improve the effectiveness of treatment, researchers emphasize personalized adjuvant therapies along with conventional ones. Targeted chemotherapeutic drug delivery systems and specific pathway-blocking agents using nanocarriers are a few of them. This study explored the nanocarrier roles and strategies to improve the treatment profile’s effectiveness by striving for TME. A biofunctionalized nanocarrier stimulates biosystem interaction, cellular uptake, immune system escape, and vascular changes for penetration into the TME. Inorganic metal compounds scavenge reactive oxygen species (ROS) through their photothermal effect. Stroma, hypoxia, pH, and immunity-modulating agents conjugated or modified nanocarriers co-administered with pathway-blocking or condition-modulating agents can regulate extracellular matrix (ECM), Cancer-associated fibroblasts (CAF),Tyro3, Axl, and Mertk receptors (TAM) regulation, regulatory T-cell (Treg) inhibition, and myeloid-derived suppressor cells (MDSC) inhibition. Again, biomimetic conjugation or the surface modification of nanocarriers using ligands can enhance active targeting efficacy by bypassing the TME. A carrier system with biofunctionalized inorganic metal compounds and organic compound complex-loaded drugs is convenient for NSCLC-targeted therapy.

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Platinum Nanoparticles: The Potential Antioxidant in the Human Lung Cancer Cells

Cited by 19 publications

References 56 publications

Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications

Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications

Assessment of the Potential Health Risk of Gold Nanoparticles Used in Nanomedicine

Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer

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