Platinum prodrug nanoparticles inhibiting tumor recurrence and metastasis by concurrent chemoradiotherapy

Abstract

Background Although concurrent chemoradiotherapy (CRT), as one of the most effective antineoplastic therapies in clinic, can successfully inhibit the growth of tumor cells, a risk of developing secondary tumor is still an insurmountable barrier in clinical practice. Results Herein, a new platinum prodrug composed of tannic acid (TA) and Pt2+ (TA-Pt) complex film was synthesized on the surface of Fe2O3 nanoparticles (NPs) with excellent stability and biocompatibility for enhanced CRT. In this system, TA-Pt complex could respond to the tumor acidic microenvironment and damage the DNA of tumor cells. Moreover, the internal iron core not only improved the effect of subsequent radiotherapy (RT), but also disrupted the iron balance in cells, inducing intracellular ferroptosis and eliminating apoptosis-resistant cells. In vitro and vivo experimental results indicated that more than 90% of tumor cells were depleted and more than 75% of the cured tumor-bearing mice evinced no recurrence or metastasis. Conclusions This work offered a new idea for combining the effective chemotherapy, RT and ferroptosis therapy to enhance the curative effect of CRT and inhibit tumor recurrence and metastasis. Graphical Abstract

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

“…in chemotherapy and chemoradiotherapy [108]. Considering the effective antioxidant property and anti-tyrosinase activity of PtNPs, developing these nanoparticles as anticancer agents can be one of the most valuable approaches for clinical use [109,110]. In order to improve therapeutic efficacy, functionalization of the surface of PtNPs could help to increase biodistribution, accumulation, cell-specific targeting, and controlled release, and reduce side effects to human beings.…”

Nanomaterials as Theranostic Agents for Cancer Therapy

“…for treatment using chemotherapy and chemoradiotherapy . The notable antioxidant capability and antityrosinase function of PtNPs helps in the emergence of these nanoparticles as anticancerous agents and can be a promising approach for clinical uses. , The surface of PtNPs is functionalized to enhance the effectivity of therapeutic treatment by increasing biodistribution, promoting accumulation, and enabling cell-specific targeting and controlled release, thereby reducing the side effects. Multiple studies have been done to display the excellent chemotherapeutic effect of platinum-based anticancer drugs, but radiosensitizing and synergistic effects of PtNPs have been discovered but studied less for radiation therapy.…”

Correction to: Platinum prodrug nanoparticles inhibiting tumor recurrence and metastasis by concurrent chemoradiotherapy

“…Following publication of the original article [ 1 ], the author reported that the corresponding author symbols were omitted from the author group. Dr. Jianfeng Cai and Peipei Xu have been added to the author group and are presented correctly in this correction article.…”