Platycodin D inhibits glioblastoma cell proliferation, migration, and invasion by regulating DEPDC1B-mediated epithelial-to-mesenchymal transition

Ouyang, Jia; Li, Haima; Wu, Guangyong; Hei, Bo; Liu, Ruen

doi:10.1016/j.ejphar.2023.176074

European Journal of Pharmacology

2023

DOI: 10.1016/j.ejphar.2023.176074

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Platycodin D inhibits glioblastoma cell proliferation, migration, and invasion by regulating DEPDC1B-mediated epithelial-to-mesenchymal transition

Jia Ouyang,

Haima Li,

Guangyong Wu

et al.

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2024

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Cited by 2 publications

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XTP8 Promotes Ovarian Cancer Progression by Activating AKT/AMPK/mTOR Pathway to Regulate EMT

Zhao,

Ning,

et al. 2024

Cell Biochem Biophys

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Ovarian cancer (OC) ranks as the fifth leading cause of cancer-related death in women. The main contributors to the poor prognosis of ovarian cancer are the high rates of recurrence and metastasis. Studies have indicated a crucial role for hepatitis B virus X Ag-Transactivated Protein 8 (XTP8), a protein containing the DEP domain, in various cellular processes, including cell growth, movement, and differentiation, across several types of cancers. However, the role of XTP8 in ovarian cancer remains unclear. We observed elevated expression of XTP8 in ovarian cancer. Silencing XTP8 inhibited cell proliferation, promoted apoptosis, and yielded contrasting results in cells overexpressing XTP8. Furthermore, XTP8 facilitated ovarian cancer invasion and migration, triggering epithelial-mesenchymal transition (EMT). Mechanistically, XTP8 silencing led to reduced phosphorylation levels of AKT, increased p-AMPK levels, and decreased p-mTOR levels, while XTP8 overexpression exerted the opposite effects. Additionally, the activation of p-AMPK rescued the promoting effect of XTP8 on EMT in ovarian cancer cell lines, indicating that XTP8 acts as an oncogene by modulating the AKT/AMPK/mTOR pathway. Through transcriptome sequencing to identify downstream targets of XTP8, we found that XTP8 influences the expression of Caldesmon (CALD1) at both transcriptional and translational levels. CALD1 can be considered a downstream target of XTP8. The collaborative action of XTP8 and CALD1 activates the AKT/AMPK/mTOR pathway, regulating EMT to promote ovarian cancer progression. Inhibiting this signaling axis might represent a potential therapeutic target for ovarian cancer.

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XTP8 Promotes Ovarian Cancer Progression by Activating AKT/AMPK/mTOR Pathway to Regulate EMT

Zhao,

Ning,

et al. 2024

Cell Biochem Biophys

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Navigating the Potential of Natural Products through Nano-enabled Drug Deliveries in Mitigation of Cancer: A Review

Guleria,

Malhan,

Singh

et al. 2024

Nano LIFE

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Approximately 20 million new instances of cancer and 10 million cancer-related deaths were reported in 2023, making cancer one of the leading causes of mortality globally. The number of deaths due to cancer worldwide is expected to double by 2050 to an estimated 18.5 million, compared to 9.7 million in 2022. Though there are heaps of new advanced techniques and therapies present for the treatment or control of cancer exist; however, complete treatment is not yet available. Chemotherapy and radiation-based therapy are examples of cancer treatments that function by eradicating or damaging cancer cells, which may sometimes negatively affect as well as harm normal cells throughout the process. Phyto-pharmaceuticals have shown promising results in the management of cancer due to potential anticancer efficacy. There is a large variety of medicinal herbs that exhibit anticancer properties; however, few are known and not yet evaluated in humans. Recently these bioactive compounds were combined with modified medications driven by nanotechnology (NT), and drug delivery systems are being fabricated and commercialized to improve the management of cancer with positive results. Drug delivery to cancer cells can be made more effective using nano-carriers with prolong medication half-lives, improve solubility and stability, and lessen side effects in organs other than the target. The review focuses on a new nano-enabled approach to delivering the medication that leverages bioactive compounds in either entrapped or tagged to carriers. Additionally, the review provides a sense of the obstacles and constraints associated with conventional cancer therapy, as well as the bioavailability of bioactive compounds.

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Platycodin D inhibits glioblastoma cell proliferation, migration, and invasion by regulating DEPDC1B-mediated epithelial-to-mesenchymal transition

Cited by 2 publications

References 64 publications

XTP8 Promotes Ovarian Cancer Progression by Activating AKT/AMPK/mTOR Pathway to Regulate EMT

XTP8 Promotes Ovarian Cancer Progression by Activating AKT/AMPK/mTOR Pathway to Regulate EMT

Navigating the Potential of Natural Products through Nano-enabled Drug Deliveries in Mitigation of Cancer: A Review

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