Plausible role of chitosan in drug and gene delivery against resistant breast cancer cells

Nandgude, Tanaji; Pagar, Roshani

doi:10.1016/j.carres.2021.108357

Cited by 30 publications

(18 citation statements)

References 68 publications

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“…Additionally, chitosan based nanoparticle is a potential delivery system for DNA vaccine and IL-12 is an effective gene adjuvant, which can induce strong antitumor immune response. It is reported that chitosan suspension or nanoparticles have immunostimulatory activities and inhibit tumor growth by inducing polarization of macrophage to enhance antitumor activity ( Nandgude and Pagar, 2021 ). Taking chitosan solution as an adjuvant intervention for patients with lung cancer can improve immunity during radiotherapy ( Ma et al, 2015 ).…”

Section: Chitosan: Source Structure Physicochemical Properties and Ap...mentioning

confidence: 99%

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Ding

Guo

2022

Front. Pharmacol.

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Cancer has become a main public health issue globally. The conventional treatment measures for cancer include surgery, radiotherapy and chemotherapy. Among the various available treatment measures, chemotherapy is still one of the most important treatments for most cancer patients. However, chemotherapy for most cancers still faces many problems associated with a lot of adverse effects, which limit its therapeutic potency, low survival quality and discount cancer prognosis. In order to decrease these side effects and improve treatment effectiveness and patient’s compliance, more targeted treatments are needed. Sustainable and controlled deliveries of drugs with controllable toxicities are expected to address these hurdles. Chitosan is the second most abundant natural polysaccharide, which has excellent biocompatibility and notable antitumor activity. Its biodegradability, biocompatibility, biodistribution, nontoxicity and immunogenicity free have made chitosan become a widely used polymer in the pharmacology, especially in oncotherapy. Here, we make a brief review of the main achievements in chitosan and its derivatives in pharmacology with a special focus on their agents delivery applications, immunomodulation, signal pathway modulation and antitumor activity to highlight their role in cancer treatment. Despite a large number of successful studies, the commercialization of chitosan copolymers is still a big challenge. The further development of polymerization technology may satisfy the unmet medical needs.

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Section: Chitosan: Source Structure Physicochemical Properties and Ap...mentioning

confidence: 99%

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Ding

Guo

2022

Front. Pharmacol.

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“…Ligand-targeted drug delivery helps to elicit distinct therapeutic effects, maximize therapeutic response, and minimize the toxicity of drugs [42,43]. Ligands attach to clustered receptors which are overexpressed on the cancer cell surface.…”

Section: Ligand Decorated Chitosan For Targeted Drug Deliverymentioning

confidence: 99%

Using Chitosan or Chitosan Derivatives in Cancer Therapy

et al. 2021

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Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

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“…The same profile was observed in lung cancer mouse models, where paclitaxel loaded onto chitosan-liposome resulted in 84% inhibition of tumour growth ( Miao, 2021 ). Many advantages are associated with the use of chitosan as a nanocarrier vehicle, including enhanced drug absorption, membrane interaction, resistance to migration, stimulation of the immune response and prolonged drug release ( Nandgude and Pagar, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Nanocarriers for anticancer drugs: Challenges and perspectives

Alqosaibi

2022

Saudi Journal of Biological Sciences

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Plausible role of chitosan in drug and gene delivery against resistant breast cancer cells

Cited by 30 publications

References 68 publications

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Recent Advances in Chitosan and its Derivatives in Cancer Treatment

Using Chitosan or Chitosan Derivatives in Cancer Therapy

Nanocarriers for anticancer drugs: Challenges and perspectives

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