Play behavior and stress responsivity in periadolescent offspring exposed prenatally to cocaine

Wood, Robin; Molina, Vı́ctor A.; Wagner, Jennifer M.; Spear, Linda P.

doi:10.1016/0091-3057(95)00120-l

Cited by 65 publications

(56 citation statements)

References 21 publications

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“…There was also increased aggression in FGDs prenatally exposed to cocaine but with no significant chnages in oxytocin levels in the amygdala Cocaine-treated dams and offspring prenatally exposed to cocaine have demonstrated significant alterations in stress reactivity (Bilitzke and Church 1992;Kehoe and Boylan 1992;Molina et al 1994;Wood et al 1995;Barron et al 2000;Goeders 2002), which could indicate a role for stress related increases in MA in the cocaine exposed FGDs, rather than a direct oxytocin effect.…”

Section: Discussionmentioning

confidence: 91%

“…Prenatal exposure to cocaine has been demonstrated to alter stress responsivity, general play behaviors (Wood et al 1994(Wood et al , 1995, ability to elicit play solicitations from an UN conspecific Overstreet et al 2000), maternal behavior onset and pup-induced maternal behavior (Johns et al 2005;Johns et al 2007), and social/ aggressive behavior at older ages (Johns et al 1994a;Overstreet et al 2000). Given the history of effects following prenatal cocaine exposure in rats, we expected to see more effects of prenatal exposure to cocaine in the offspring.…”

Section: Discussionmentioning

confidence: 99%

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Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams

McMurray

Joyner

Middleton

et al. 2008

Stress

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Gestational cocaine treatment results in significantly increased maternal aggression towards an intruder by postpartum day six, while acute postpartum treatment dose dependently decreases maternal aggressive (MA) behavior. Both increased and decreased aggression in the cocainetreated dams are correlated with either decreased or increased levels of oxytocin in the amygdala, respectively. The current study was an effort to determine whether the effect of gestational cocaine on maternal aggression is transient or would continue into the postpartum period; whether an intermittent cocaine treatment regimen, which incorporates gestational and postpartum intermittent cocaine treatment, would differ from chronic daily gestational treatment; and finally, whether next generation female offspring of cocaine-treated or control dams would have altered MA behavior and oxytocin system changes attributable to either prenatal drug exposure, rearing condition or both. We now report no increase in maternal aggression following chronic gestational treatment and significantly lower levels of aggression in intermittently treated dams on postpartum day eight, with no significant effects in either group on postpartum day 12. Young adult female offspring of the cocaine-treated and control dams, who reared their own natural litters and were tested on postpartum day eight for maternal aggression, had higher levels of maternal aggression towards an intruder attributable to both prenatal cocaine exposure and rearing condition. Higher aggression in cocaine-reared next generation dams was associated with lower levels of oxytocin in the amygdala. Intergenerational effects of cocaine were apparent with respect to aggression and oxytocin system changes.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams

McMurray

Joyner

Middleton

et al. 2008

Stress

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“…However, these rats became more aggressive during the competition for water, suggesting some enduring effects on emotional behavior [23,39]. Other work has shown that early play behavior was altered in rats given prenatal cocaine treatment, such that they were more submissive and less likely to solicit play than normal animals [37,38]. Prenatal exposure to cocaine has also been demonstrated to have gender-specific effects on social or aggressive behavior.…”

Section: Introductionmentioning

confidence: 98%

Enduring effects of prenatal cocaine administration on emotional behavior in rats

Overstreet

Moy

et al. 2000

Physiology & Behavior

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The present studies sought to determine whether prenatal cocaine administration (15 mg/kg b.i.d. between gestational ages 1-20) had enduring effects on emotional behavior of rats. Rats prenatally treated with cocaine interacted less with other rats in the social interaction test of anxiety at both 30 and 120 days of age. However, there were no differences in the elevated plus maze test of anxiety. Rats prenatally treated with cocaine were significantly more immobile in the forced-swim test at 60 and 120 days of age. In addition, animals exposed to prenatal cocaine were more sensitive to the enhancing effect of phencyclidine (2.0 mg/kg) on startle responses to an acoustic stimulus. The cocaine-treated animals tested at 50 to 60 days of age showed higher levels of prepulse inhibition, in comparison to the saline group, after vehicle pretreatment, but not after phencyclidine. Although there were gender differences in the expression of some of these behavioral tasks, there were no gender differences in the effects of cocaine. These findings indicate that when emotional behavior is altered by prenatal cocaine administration, the effects are enduring.

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“…Our findings suggest that prenatal cocaine exposure alone has little effect on pup-induced maternal behavior in the late juvenile period with no sex-related effects in PND 28 offspring. Expectations of differences resulting from prenatal exposure to cocaine in the PND 28 offspring were based on data showing that prenatal cocaine exposure has been associated with deficits in play behavior and play solicitation in young juvenile offspring [4,52,53]. Since these behaviors have components similar to those involved in pup retrieval and social interaction, it is interesting that there was no translation of disruption of pup-induced maternal behavior resulting from prenatal exposure in our study.…”

Section: Discussionmentioning

confidence: 84%

“…Various rodent studies have reported numerous effects of prenatal exposure to cocaine on subsequent adolescent and adult play, social, and aggressive behaviors [23,38,52,53]. To our knowledge, no prior study has examined the differential effects of prenatal cocaine exposure and rearing condition on next generation offspring pup-induced maternal behavior, although we have recently reported differences in postpartum maternal behavior following prenatal cocaine exposure and altered rearing conditions [17].…”

Section: Introductionmentioning

confidence: 85%

Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats

Johns

McMurray

Hofler

et al. 2007

Neurotoxicology and Teratology

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Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure. Pup-induced maternal behavior in non-lactating rats has not been examined with regard to cocaine exposure and rearing conditions. First generation male and female juveniles and young adult males reared by cocaine-treated or control dams and prenatally exposed to either cocaine or control conditions were tested for pup-induced maternal behavior at postnatal days 28 and 60. We now report disruptions in pup-induced maternal behavior in both 28 and 60 day old first generation offspring attributable to rearing condition and prenatal cocaine exposure.

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Play behavior and stress responsivity in periadolescent offspring exposed prenatally to cocaine

Cited by 65 publications

References 21 publications

Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams

Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams

Enduring effects of prenatal cocaine administration on emotional behavior in rats

Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats

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