Play in advance against neurodegeneration: exploring enteric glial cells in gut-brain axis during neurodegenerative diseases

Seguella, Luisa; Capuano, Riccardo; Sarnelli, Giovanni; Esposito, Giuseppe

doi:10.1080/17512433.2019.1612744

Cited by 25 publications

(26 citation statements)

References 98 publications

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“…In this way, the suggestion that PD could onset in the gut emerges from the identification of activated EGCs, local inflammation, impaired IEB, aggregation of α-synuclein in neurons, and GI disorders in a window prior to the appearance of classic motor deficits. Recently, Seguella et al suggest that EGCs could be the "missing link" that connects the ENS to the CNS [139]. The authors called attention to enteric glial cell-mediated inflammatory response, which could reach the CNS by the gut-brain axis and lead to neuronal cell death and disruption of synaptic interactions [139,140].…”

Section: Parkinson's Diseasementioning

confidence: 99%

“…Recently, Seguella et al suggest that EGCs could be the "missing link" that connects the ENS to the CNS [139]. The authors called attention to enteric glial cell-mediated inflammatory response, which could reach the CNS by the gut-brain axis and lead to neuronal cell death and disruption of synaptic interactions [139,140]. Thus, EGCs would function as an "entrance door" to noxious stimuli from the intestinal lumen that could damage the CNS.…”

Section: Parkinson's Diseasementioning

confidence: 99%

“…Thus, EGCs would function as an "entrance door" to noxious stimuli from the intestinal lumen that could damage the CNS. However, the mechanisms by which the pro-inflammatory glial mediators rise to the CNS still remains to be clarified [139].…”

Section: Parkinson's Diseasementioning

confidence: 99%

“…The discussion of the peripheral immune response has been widely debated as the pathogenic pattern of AD that contributes to central neurodegeneration [145,146]. In this context, some discussion has been raised about EGC possibly acting as a peripheric coordinator of immune differentiation of T cells [139] since EGCs express the major histocompatibility complex II and T-cell costimulatory molecules [147][148][149]. As mentioned above, EGCs are able to respond to an inflammatory environment contributing to the process, activate enteric neurodegenerative mechanisms, and immunomodulate the IEB.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

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The Enteric Glial Network Acts in the Maintenance of Intestinal Homeostasis and in Intestinal Disorders

Coelho-Aguiar¹,

Veríssimo²,

Costa³

et al. 2020

Glia in Health and Disease

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The enteric nervous system (ENS), also known as second brain, innervates our gastrointestinal tract controlling its functions, such as motility, fluid secretion, nutrient absorption, and even involvement in the control of immunity and inflammatory processes. In the gut, the gliocytes are known as enteric glial cells (EGCs). Enteric glial cells form a network that permeates the entire gut. Enteric glia express the cell surface hemichannel of connexin-43 (Cx43) necessary for the propagation of Ca2 + responses, necessary to maintain their functions. In this chapter, besides the development of ENS and its glial cells and the similarities with the astrocytes in the central nervous system, we approached the important role of the glial network in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions. EGCs are even capable of replacing lost neurons. Thus the enteric glia is a multifunctional cell, which through its multiple interactions maintains the integrity of the ENS allowing it to be resistant to the different and constant aggressions suffered by the digestive system.

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Section: Parkinson's Diseasementioning

confidence: 99%

Section: Parkinson's Diseasementioning

confidence: 99%

Section: Parkinson's Diseasementioning

confidence: 99%

Section: Alzheimer's Diseasementioning

confidence: 99%

See 2 more Smart Citations

The Enteric Glial Network Acts in the Maintenance of Intestinal Homeostasis and in Intestinal Disorders

Coelho-Aguiar¹,

Veríssimo²,

Costa³

et al. 2020

Glia in Health and Disease

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show abstract

“…The neuroglial junctions, calcium signals and neurotransmitter receptors on EGCs, allows for communication with the ENS (Sharkey, 2015;Ochoa-Cortes et al, 2016). Dysfunction of each of these has been implicated as a possible source for gut mobility issues and possibly even neurodegeneration (Coelho-Aguiar et al, 2015;Ochoa-Cortes et al, 2016;Sequella, Capuana, Sarnelli, & Esposito, 2019). Furthermore, EGCs have been proposed to serve as a reservoir for prions and aberrant alpha-synuclein; with several studies showing that these molecules are readily able to travel from the gut to the brain and vice versa (Albanese et al, 2008;Sharkey, 2015).…”

Section: Decreased Cell Mobilization With Glial Activationmentioning

confidence: 99%

The Impact of Bacteriophage on the Aging Brain and Inflammatory Response: Relevance to Parkinson’s Disease

Beauchamp¹

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Parkinson's disease (PD) is associated with age and inflammation. New studies have found a link between gut dysbiosis and the prevalence of PD. Phage 936, which is found in dairy products, has been associated with disruptions in the gut microbiome and leaky gut causalities. The present thesis sought to assess the impact of phage 936 in young or old mice and whether the virus augments or diminishes the impact of an inflammatory (LPS) stimulus. To this end, an initial study was conducted to first determine if bacteriophage alone could actually produce some degree of measurable changes (e.g. neutrophil mobilization or change in cytokine or other circulating

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Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

Liang

Saunders

Sanossian

2023

Food Science & Nutrition

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Dysfunction of gut barrier is known as “leaky gut” or increased intestinal permeability. Numerous recent scientific evidences showed the association between gut dysfunction and multiple gastrointestinal tract (GI) and non‐GI diseases. Research also demonstrated that food plays a crucial role to cause or remedy gut dysfunction related to diseases. We reviewed recent articles from electronic databases, mainly PubMed. The data were based on animal models, cell models, and human research in vivo and in vitro models. In this comprehensive review, our aim focused on the relationship between dietary factors, intestinal permeability dysfunction, and related diseases. This review synthesizes currently available literature and is discussed in three parts: (a) the mechanism of gut barrier and function, (b) food and dietary supplements that may promote gut health, and food or medication that may alter gut function, and (c) a table that organizes the synthesized information by general mechanisms for diseases related to leaky gut/intestinal permeability and associated dietary influences. With future research, dietary intervention could be a new target for individualized disease prevention and management.

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Play in advance against neurodegeneration: exploring enteric glial cells in gut-brain axis during neurodegenerative diseases

Cited by 25 publications

References 98 publications

The Enteric Glial Network Acts in the Maintenance of Intestinal Homeostasis and in Intestinal Disorders

The Enteric Glial Network Acts in the Maintenance of Intestinal Homeostasis and in Intestinal Disorders

The Impact of Bacteriophage on the Aging Brain and Inflammatory Response: Relevance to Parkinson’s Disease

Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

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