Play of molecular host: guest assembly on a G-quadruplex binder

Alexander, Aleyamma; Pillai, Archana Sumohan; Grace, Sudhaker Raboni; Ananthi, Nallamuthu; Pal, Haridas; Enoch, Israel V.M.V.; Sayed, Mhejabeen

doi:10.1007/s10847-023-01185-2

J Incl Phenom Macrocycl Chem

2023

DOI: 10.1007/s10847-023-01185-2

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Play of molecular host: guest assembly on a G-quadruplex binder

Aleyamma Alexander

Archana Sumohan Pillai

Sudhaker Raboni Grace

et al.

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Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids

Lebedeva,

Yurina,

Guseinov

et al. 2023

J Incl Phenom Macrocycl Chem

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Porphyrins, owing to their unique physicochemical properties, hold great potential as candidates for the synthesis of new materials and active pharmaceutical drugs. The introduction of functional groups into porphyrin structures enables the creation of novel compounds with nely tuned structural and optical properties, as well as complex-forming abilities. In this study, spectral and thermochemical investigations were conducted to explore the complex formation of a cationic porphyrin containing benzimidazole residues with synthetic (poly[d(GC)2], poly[d(AT)2]) and natural (ssDNA, ctDNA) nucleic acids. It was observed that the porphyrin forms complexes with poly[d(AT)2] and ssDNA, localized within the major groove of the biopolymer. Additionally, the porphyrin forms multiple intercalation complexes with varying geometries when interacting with poly[d(GC)2] and ctDNA. These ndings demonstrate a new potential for enhancing the selective binding of ligands with nucleic acids (NA). Moreover, the study highlights the methodological aspect that establishing the type of formed complexes based on ligands' electronic absorption spectra, known as " ngerprints," may lead to incorrect conclusions.

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Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids

Lebedeva,

Yurina,

Guseinov

et al. 2023

J Incl Phenom Macrocycl Chem

View full text Add to dashboard Cite

show abstract

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Play of molecular host: guest assembly on a G-quadruplex binder

Cited by 1 publication

References 60 publications

Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids

Complexes of cationic non-symmetric porphyrin with synthetic and natural nucleic acids

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