Playback of Alarm and Appetitive Calls Differentially Impacts Vocal, Heart-Rate, and Motor Response in Rats

Olszyński, Krzysztof H.; Polowy, Rafał; Małż, Monika; Boguszewski, Paweł M.; Filipkowski, Robert K.

doi:10.1016/j.isci.2020.101577

Cited by 18 publications

(31 citation statements)

References 62 publications

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“…With respect to playback in the first test, SAL-treated rats showed responses to 50-kHz USV playback which, in qualitative terms, are largely similar to those of Experiments 1 and 2, namely increases in proximal zone entries and dwell times. This indicates that the effectiveness of 50-kHz USV playback to elicit approach cannot only be gauged by using a radial maze, but also by the more simplified platform version, where approach is evaluated by analysis of virtual zones in line with a recent report on social approach evoked by playback of 50-kHz USV in a home cage (Olszy nski et al, 2020). Using the platform, we found that HALO partly blocked the approach to presentation of 50-kHz USV, which only led to an increase in proximal zone times but not proximal zone entries.…”

Section: Experiments 3: State-dependencymentioning

confidence: 90%

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Limited generalizability, pharmacological modulation, and state-dependency of habituation towards pro-social 50-kHz calls in rats

et al. 2021

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Communication constitutes a fundamental component of mammalian social behavior. Rats are highly social animals and emit 50-kHz ultrasonic vocalizations (USV), which function as social contact calls. Playback of 50-kHz USV leads to strong and immediate social approach responses in receiver rats, but this response is weak or even absent during repeated 50-kHz USV playback. Given the important role of 50-kHz USV in initiating social contact and coordinating social interactions, the occurrence of habituation is highly unexpected. It is not clear why a social signal characterized by significant incentive salience loses its power to change the behavior of the receiver so rapidly. Here, we show that the habituation phenomenon displayed by rats in response to repeated playback of 50-kHz USV (1) is characterized by limited generalizability because it is present in Wistar but not Sprague-Dawley rats, (2) can be overcome by amphetamine treatment, and (3) depends on the subject's internal state.

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Section: Experiments 3: State-dependencymentioning

confidence: 90%

“…In aversive situations, such as predator exposure, 22-kHz USV occur, which probably express distress and serve as alarm signals to others (e.g. Blanchard et al, 1991;Fendt et al, 2018;Olszy nski et al, 2020). In appetitive situations, for example roughand-tumble play or mating, 50-kHz USV are emitted (e.g.…”

Section: Introductionmentioning

confidence: 99%

Limited generalizability, pharmacological modulation, and state-dependency of habituation towards pro-social 50-kHz calls in rats

et al. 2021

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“…Although initial recordings of heart rate during the playback of ultrasonic calls did not detect changes in heart rate [ 211 ], more detailed and frequent sampling of heart rate detected changes caused by the playback. It is interesting that receivers of the ultrasonic calls develop relevant emotional arousal with autonomic changes [ 212 ]. Playback of 22 kHz vocalizations decreased heart rate in the receiver rats, while the playback of 50 kHz calls increased the rats’ heart rate.…”

Section: Evolution and Functions Of Rat Vocalizationsmentioning

confidence: 99%

“…Playback of 22 kHz vocalizations decreased heart rate in the receiver rats, while the playback of 50 kHz calls increased the rats’ heart rate. These effects were stronger in singly housed rats as compared to pair-housed rats [ 212 ].…”

Section: Evolution and Functions Of Rat Vocalizationsmentioning

confidence: 99%

Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation

Brudzyński

2021

Brain Sciences

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This review summarizes all reported and suspected functions of ultrasonic vocalizations in infant and adult rats. The review leads to the conclusion that all types of ultrasonic vocalizations subserving all functions are vocal expressions of emotional arousal initiated by the activity of the reticular core of the brainstem. The emotional arousal is dichotomic in nature and is initiated by two opposite-in-function ascending reticular systems that are separate from the cognitive reticular activating system. The mesolimbic cholinergic system initiates the aversive state of anxiety with concomitant emission of 22 kHz calls, while the mesolimbic dopaminergic system initiates the appetitive state of hedonia with concomitant emission of 50 kHz vocalizations. These two mutually exclusive arousal systems prepare the animal for two different behavioral outcomes. The transition from broadband infant isolation calls to the well-structured adult types of vocalizations is explained, and the social importance of adult rat vocal communication is emphasized. The association of 22 kHz and 50 kHz vocalizations with aversive and appetitive states, respectively, was utilized in numerous quantitatively measured preclinical models of physiological, psychological, neurological, neuropsychiatric, and neurodevelopmental investigations. The present review should help in understanding and the interpretation of these models in biomedical research.

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“…We recently discovered changes in locomotion, USV emission, and HR in Wistar rats exposed to ultrasonic playback from a speaker [26]. In particular, 50-kHz playback elicited abundant appetitive vocalization, increased HR, and locomotor activity.…”

Section: Introductionmentioning

confidence: 99%

Increased Vocalization of Rats in Response to Ultrasonic Playback as a Sign of Hypervigilance Following Fear Conditioning

et al. 2021

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We investigated the effects of prior stress on rats’ responses to 50-kHz (appetitive) and 22-kHz (aversive) ultrasonic playback. Rats were treated with 0, 1, 6 or 10 shocks (1 s, 1.0 mA each) and were exposed to playbacks the following day. Previous findings were confirmed: (i) rats moved faster during 50-kHz playback and slowed down after 22-kHz playback; (ii) they all approached the speaker, which was more pronounced during and following 50-kHz playback than 22-kHz playback; (iii) 50-kHz playback caused heart rate (HR) increase; 22-kHz playback caused HR decrease; (iv) the rats vocalized more often during and following 50-kHz playback than 22-kHz playback. The previous shock affected the rats such that singly-shocked rats showed lower HR throughout the experiment and a smaller HR response to 50-kHz playback compared to controls and other shocked groups. Interestingly, all pre-shocked rats showed higher locomotor activity during 50-kHz playback and a more significant decrease in activity following 22-kHz playback; they vocalized more often, their ultrasonic vocalizations (USV) were longer and at a higher frequency than those of the control animals. These last two observations could point to hypervigilance, a symptom of post-traumatic stress disorder (PTSD) in human patients. Increased vocalization may be a valuable measure of hypervigilance used for PTSD modeling.

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Playback of Alarm and Appetitive Calls Differentially Impacts Vocal, Heart-Rate, and Motor Response in Rats

Cited by 18 publications

References 62 publications

Limited generalizability, pharmacological modulation, and state-dependency of habituation towards pro-social 50-kHz calls in rats

Limited generalizability, pharmacological modulation, and state-dependency of habituation towards pro-social 50-kHz calls in rats

Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation

Increased Vocalization of Rats in Response to Ultrasonic Playback as a Sign of Hypervigilance Following Fear Conditioning

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