With the purpose of quantifying the differences in the running performance of soccer players during matches from different continental confederations, data of 1508 match observations generated from 559 players in 59 matches at the 2018 FIFA World Cup held in Russia were analyzed. Generalized mixed linear modeling was carried out to estimate the effect of confederations on each of the selected thirteen match running performance related variables (total distance covered, top speed achieved, number of sprints, distance covered and time spent in walking, jogging, low-speed running, moderate-speed running, and high-speed running), controlling the effects of match result, competition phase, and team and opponent strength. Results showed that the differences in the match running performance of UEFA and CONMEBOL players were trivial (ES between 0.04 and 0.14); players from AFC, CAF, and CONCACAF covered less total distance (ES between 0.26 and 0.54), spent less playing time, and covered less distance in jogging and low-speed running (ES between 0.20 and 0.53), whereas they spent more time walking (ES between 0.27 and 0.41) as compared with players from UEFA and CONMEBOL; top speed achieved, number of sprints made, and time spent and distance covered in the moderate- and high-speed running intensity zones by players from all confederations were similar (ES between 0.01 and 0.15), with an exception that high-speed-running distance covered by CONCACAF players was less than that by CAF players (2.0 ± 1.5 m/min vs. 2.3 ± 1.7 m/min, ES = 0.23, ±90% CL: ±0.21).