Plectranthus tenuiflorus (Shara) Promotes Wound Healing: In vitro and in vivo Studies

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

“…This phase has the fibroblasts as main agents, which produce the collagen and deposit it in a structured way, promoting resistance . Collagenization was seen in the treatment of wounds with thymol . In addition, thymol is able to promote complete replacement of type III to type I collagen in 14 days, indicating a normal, dynamic collagenation as previously reported in other experimental wound healing studies with red propolis and usnic acid .…”

“…Afterwards, Khorshid et al . performed in vivo and in vitro tests using EO from Plectranthus tenuiflorus (thymol 85.3%).…”

Anti-inflammatory and cicatrizing activities of thymol, a monoterpene of the essential oil from Lippia gracilis, in rodents

“…Besides, the denser disposition and better arrangement of these fibers seen in COLTHY group in 21 day is suggestive that thymol may play an important modulatory effect on the fibroblast metabolism and collagen synthesis. Supporting this theory, it has been previously demonstrated that thymol is able to enhance the fibroblasts growth in vitro, even at quite low concentrations (0.0005%) (Khorshid et al, 2010). Considering that fibroblasts are responsible for both synthesis and degradation of collagen, the remodeling phase of wound healing is utterly dependent on the biological activity of such cell subsets.…”

Kinetic and in silico studies of novel hydroxy-based thymol analogues as inhibitors of mushroom tyrosinase

“…Thymol displays antimicrobial [18e20] and wound-healing activity [21] and is able to rise the levels of macrophage migration inhibitory factor (MIF) in central nervous system [22]. Thymol increased the in vitro fibroblast growth [23], effectively inhibited COX-1 [24] and prevented inducible lymphocyte proliferation [25].…”